Increased iris thickness and association with primary angle closure glaucoma

Wang, B. S.; Narayanaswamy, Arun; Amerasinghe, Nishani; Zheng, Ce; He, Mingguang; Chan, Yiong‐Huak; Nongpiur, Monisha E.; Friedman, David S.; Aung, Tin

doi:10.1136/bjo.2009.178129

Cited by 145 publications

(117 citation statements)

References 27 publications

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“…Optical coherence tomography measurement differences between quadrants in PACS eyes (control group, n = 58) and APAC fellow eyes (case group, n = 19). Related to the increased iris thickness, Wang et al [12] coincide that it is independently associated with angle closure as it have been proposed by several authors [13].…”

Section: Discussionmentioning

confidence: 82%

Anterior Segment Parameters Associated to Acute Glaucoma with Slit Lamp Optical Coherence Tomography

Argones¹,

Díaz²,

Deustua³

et al. 2014

OJOph

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The acute primary angle closure is an ophthalmological urgency which requires immediate treatment to prevent permanent damaged.The population studies reveal that more than a half of predispose individuals will not manifest the disease. This reality, the cost of laser prophylactic treatment, the risk of ocular complications and the low accessibility to the technology in some populations justify that proper investigations go on to define the morphological and/or functional factors that determine the acute presentation of the disease [1].The optical coherence tomography is a high resolution, non invasive technology that offers the possibility to

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Section: Discussionmentioning

confidence: 82%

Anterior Segment Parameters Associated to Acute Glaucoma with Slit Lamp Optical Coherence Tomography

Argones¹,

Díaz²,

Deustua³

et al. 2014

OJOph

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“…The utility of AS-OCT in the diagnosis and management of various anterior segment conditions has been studied in the past (5,6,(16)(17)(18) . In particular, Prata et al used AS-OCT to show iris thinning in patients taking systemic alpha-1 adrenergic receptor antagonists associated with intraoperative floppy iris syndrome (19) .…”

Section: Discussionmentioning

confidence: 99%

“…Commercially available corneal tomography systems that use a rotating Scheimpflug cameras have been proposed to help identify forme fruste keratoconus (4) , and high-speed anterior segment optical coherence tomography has been shown to have good repeatability and reproducibility with ocular structures and iris area measurements (5)(6)(7)(8)(9) . In a subset of keratoconus patients undergoing penetrating keratoplasty (PKP), we have observed that the iris can show a tendency to prolapse toward the incisions and be less responsive to pharmacological agents.…”

Section: Introductionmentioning

confidence: 99%

Quantitative analysis of iris parameters in keratoconus patients using optical coherence tomography

Bonfadini¹,

Arora²,

Vianna³

et al. 2015

Arquivos Brasileiros De Oftalmologia

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Purpose: To investigate the relationship between quantitative iris parameters and the presence of keratoconus. Methods: Cross-sectional observational study that included 15 affected eyes of 15 patients with keratoconus and 26 eyes of 26 normal age-and sex-matched controls. Iris parameters (area, thickness, and pupil diameter) of affected and unaffected eyes were measured under standardized light and dark conditions using anterior segment optical coherence tomography (AS-OCT). To identify optimal iris thickness cutoff points to maximize the sensitivity and specificity when discriminating keratoconus eyes from normal eyes, the analysis included the use of receiver operating characteristic (ROC) curves. Results: Iris thickness and area were lower in keratoconus eyes than in normal eyes. The mean thickness at the pupillary margin under both light and dark conditions was found to be the best parameter for discriminating normal patients from keratoconus patients. Diagnostic performance was assessed by the area under the ROC curve (AROC), which had a value of 0.8256 with 80.0% sensitivity and 84.6% specificity, using a cutoff of 0.4125 mm. The sensitivity increased to 86.7% when a cutoff of 0.4700 mm was used. Conclusions: In our sample, iris thickness was lower in keratoconus eyes than in normal eyes. These results suggest that tomographic parameters may provide novel adjunct approaches for keratoconus screening.

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“…[33][34][35][36][37] Aptel and Denis 34 estimated the iris volume by capturing four cross-sectional images of the anterior segment at 451-intervals. They showed that iris volume increased from B45 mm 3 to 50 mm 3 after pharmacologic mydriasis in the fellow non-attacked eyes of patients with history of acute primary angle closure.…”

Section: Reliability Of Anterior Segment Oct For Measurement Of the Amentioning

confidence: 99%

Anterior chamber angle imaging with optical coherence tomography

Leung

Weinreb

2011

Eye

102

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The technology of optical coherence tomography (OCT) has evolved rapidly from time-domain to spectral-domain and swept-source OCT over the recent years. OCT has become an important tool for assessment of the anterior chamber angle and detection of angle closure. Improvement in image resolution and scan speed of OCT has facilitated a more detailed and comprehensive analysis of the anterior chamber angle. It is now possible to examine Schwalbe's line and Schlemm's canal along with the scleral spur. High-speed imaging allows evaluation of the angle in 3601. With three-dimensional reconstruction, visualization of the iris profiles and the angle configurations is enhanced. This article summarizes the development and application of OCT for anterior chamber angle measurement, detection of angle closure, and investigation of the pathophysiology of primary angle closure.

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Increased iris thickness and association with primary angle closure glaucoma

Cited by 145 publications

References 27 publications

Anterior Segment Parameters Associated to Acute Glaucoma with Slit Lamp Optical Coherence Tomography

Anterior Segment Parameters Associated to Acute Glaucoma with Slit Lamp Optical Coherence Tomography

Quantitative analysis of iris parameters in keratoconus patients using optical coherence tomography

Anterior chamber angle imaging with optical coherence tomography

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