Increased intraventricular pressures are as harmful as the electrophysiological substrate of heart failure in favoring sustained reentry in the swine heart

Quintanilla, Jorge G.; Moreno, Javier; Archondo, Tamara; Usandizaga, E.; Molina-Morua, R.; Rodríguez-Bobada, Cruz; González, Pablo; García‐Torrent, María Jesús; Filgueiras‐Rama, David; Pérez‐Castellano, Nicasio; Macaya, Carlos; Pérez-Villacastín, Julián

doi:10.1016/j.hrthm.2015.05.017

Cited by 17 publications

(21 citation statements)

References 32 publications

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“…After 10 weeks, collagen volume fraction of left atrio-ventricular and kidney tissues reduced significantly in RDN group compared with the Sham group. 24) In our study, four patients had ejection fraction < 37%, which was comparable with other researches. Among the other four patients with normal or near normal ejection fraction, one was coronary artery disease, one was dilated cardiomyopathy, one was hypertrophic cardiomyopathy, and one was idiopathic cardiomyopathy with left ventricular aneurysm.…”

Section: Discussionsupporting

confidence: 91%

“…5,7,8) More recently, we demonstrated another probable long-term protective mechanism that RDN could reduce cardiac fibrosis. 24) Thirty-one survival isoproterenol-induced cardiomyopathy rats were randomized into the RDN (n = 15) and Sham group (n = 16). After 10 weeks, collagen volume fraction of left atrio-ventricular and kidney tissues reduced significantly in RDN group compared with the Sham group.…”

Section: Discussionmentioning

confidence: 99%

“…In prior animal researches, we had already found that RDN could suppress norepinephrine spillover. 24,32) However, many researchers used the term "renal denervation" instead of "intra-renal artery ablation." Scientifically, as long as denervation is not examined in the individuals, the intravascular procedure cannot be called the "denervation."…”

Section: Discussionmentioning

confidence: 99%

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Renal Denervation for Ventricular Arrhythmia in Patients with Implantable Cardioverter Defibrillators

et al. 2018

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SummaryTo investigate the efficacy of renal denervation (RDN) on the recurrence of ventricular arrhythmia (VA) in Asian patients with implantable cardioverter defibrillators (ICDs).Eight ICD patients with recurrent VA episodes underwent RDN using an off-the-shelf saline-irrigated catheter. The pre-and postprocedural VA episodes were counted via ICD interrogation. All patients underwent successful RDN without any complications related to radiofrequency catheter ablation. The median follow-up was 15 months (range 6-30), and the median VA episodes per month were significantly reduced from 3.17 (range 0.33-15.33) to 0.10 (range 0-5.83) after RDN (P < 0.05).RDN is an effective suppressor of VA in Asian patients with ICDs.(Int Heart J Advance Publication)

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Renal Denervation for Ventricular Arrhythmia in Patients with Implantable Cardioverter Defibrillators

et al. 2018

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“…238 Mechanisms here may range from activation of SAC that alter APD, 239 slow conduction velocity, 173, 235, 238 or increase dispersion of repolarization, 238 over changes in expression of mechanically modulated ion channels 206 and alterations in connexin phosphorylation, 240 through to remodelling of tissue architecture, composition, 241 and innervation. 242 …”

Section: Clinical Relevancementioning

confidence: 99%

Cardiac Mechano-Gated Ion Channels and Arrhythmias

Peyronnet

Nerbonne

Kohl

2016

Circulation Research

176

167

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Mechanical forces will have been omnipresent since the origin of life, and living organisms have evolved mechanisms to sense, interpret and respond to mechanical stimuli. The cardiovascular system in general, and the heart in particular, are exposed to constantly changing mechanical signals, including stretch, compression, bending, and shear. The heart adjusts its performance to the mechanical environment, modifying electrical, mechanical, metabolic, and structural properties over a range of time scales. Many of the underlying regulatory processes are encoded intra-cardially, and are thus maintained even in heart transplant recipients. Although mechano-sensitivity of heart rhythm has been described in the medical literature for over a century, its molecular mechanisms are incompletely understood. Thanks to modern biophysical and molecular technologies, the roles of mechanical forces in cardiac biology are being explored in more detail, and detailed mechanisms of mechano-transduction have started to emerge. Mechano-gated ion channels are cardiac mechano-receptors. They give rise to mechano-electric feedback, thought to contribute to normal function, disease development, and, potentially, therapeutic interventions. In this review, we focus on acute mechanical effects on cardiac electrophysiology, explore molecular candidates underlying observed responses, and discuss their pharmaceutical regulation. From this, we identify open research questions and highlight emerging technologies that may help in addressing them. Cardiac electrophysiology is acutely affected by the heart’s mechanical environment. Mechano-electric feedback affects excitability, conduction, and electrical load, and remains an underestimated player in arrhythmogenesis. The utility of therapeutic interventions targeting acute mechano-electrical transduction is an open field worthy of further study.

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“…The interaction between myocardial deformation and conduction velocity is controversial and different studies have shown mixed results (McNary et al, 2008). Some animal (Dhein et al, 2014;Quintanilla et al, 2015;Sung et al, 2003;Zabel et al, 1996b) and computational (Kuijpers et al, 2007) studies have shown that myocardial deformation modifies conduction dynamics, while other have reported no change (Zhu et al, 1997). The underlying mechanisms of conduction dynamic changes secondary to myocardial deformation are not completely understood (Mills et al, 2008).…”

Section: Experimental Evidence Describing Cardiac Human Response To Dmentioning

confidence: 99%

Mechano-electrical feedback in the clinical setting: Current perspectives

Orini

Nanda

Yates

et al. 2017

Progress in Biophysics and Molecular Biology

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Mechano-electric feedback (MEF) is an established mechanism whereby myocardial deformation causes changes in cardiac electrophysiological parameters. Extensive animal, laboratory and theoretical investigation has demonstrated that abnormal patterns of cardiac strain can induce alteration of electrical excitation and recovery through MEF, which can potentially contribute to the establishment of dangerous arrhythmias. However, the clinical relevance of MEF in patients with heart disease remains to be established. This paper reviews up-to date experimental evidence describing the response to different types of mechanical stimuli in the intact human heart with the support of new data collected during cardiac surgery. It discusses modulatory effects of MEF that may contribute to increase the vulnerability to arrhythmia and describes MEF interaction with clinical conditions where mechanically induced changes in cardiac electrophysiology are likely to be more relevant. Finally, directions for future studies, including the need for in-vivo human data providing simultaneous assessment of the distribution of structural, functional and electrophysiological parameters at the regional level, are identified.

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Increased intraventricular pressures are as harmful as the electrophysiological substrate of heart failure in favoring sustained reentry in the swine heart

Cited by 17 publications

References 32 publications

Renal Denervation for Ventricular Arrhythmia in Patients with Implantable Cardioverter Defibrillators

Renal Denervation for Ventricular Arrhythmia in Patients with Implantable Cardioverter Defibrillators

Cardiac Mechano-Gated Ion Channels and Arrhythmias

Mechano-electrical feedback in the clinical setting: Current perspectives

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