2018
DOI: 10.1016/j.bbadis.2017.10.030
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Increased intraocular pressure alters the cellular distribution of HuR protein in retinal ganglion cells – A possible sign of endogenous neuroprotection failure

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Cited by 11 publications
(13 citation statements)
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“…From among the factors we described in this review, the human antigen R (HuR protein) seems to be the most promising endogenous target for experimental and translational therapy. In glaucoma, it has been shown that there are similar patterns of HuR protein alterations in both rat and human what allows to expect that effects of HuR-targeted therapies may have similar, thus translational outcomes ( Smedowski et al, 2018 ). HuR protein represent the pleiotropic factor that post-translationally regulates majority of described intracellular processes and molecules, especially antioxidant enzymes, growth factors, stress response factors, cell cycle regulating proteins and autophagy.…”
Section: Discussionmentioning
confidence: 99%
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“…From among the factors we described in this review, the human antigen R (HuR protein) seems to be the most promising endogenous target for experimental and translational therapy. In glaucoma, it has been shown that there are similar patterns of HuR protein alterations in both rat and human what allows to expect that effects of HuR-targeted therapies may have similar, thus translational outcomes ( Smedowski et al, 2018 ). HuR protein represent the pleiotropic factor that post-translationally regulates majority of described intracellular processes and molecules, especially antioxidant enzymes, growth factors, stress response factors, cell cycle regulating proteins and autophagy.…”
Section: Discussionmentioning
confidence: 99%
“…In healthy retinas MT I/II and III are expressed mostly in RGC axons (retinal nerve fiber layer) and the inner plexiform layer ( Suemori et al, 2006 ). Similarly, isoforms MT I and III have been detected in proteomic analyses of ON homogenates ( Smedowski et al, 2018 ). In stress conditions, expression of MT has been shown to increase within RNFL and RGC bodies, suggesting its role as an endogenous neuroprotective factor ( Suemori et al, 2006 ).…”
Section: Factors and Pathways Regulating Apoptosis/cell Death And Neumentioning
confidence: 94%
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“…For instance, a key role for Erk1/2, as well as AMPK, in AMD has been suggested [ 63 ]. Moreover, recent studies have confirmed the importance of HuR in various ocular pathologies [ 64 , 65 ] and laid the foundation for the druggability assessment of HuR protein [ 66 ]; compounds able to directly act on the HuR protein and p62 mRNA complex formation may thus represent new potential tools regulating p62 content.…”
Section: Discussionmentioning
confidence: 99%