Increased intramuscular adipose tissue of the quadriceps is related to decreased activities of daily living in patients who have had a stroke

Akazawa, Naoki; Kishi, Masaki; Hino, Toshikazu; Tsuji, Ryota; Tamura, Kimiyuki; Hioka, Akemi; Moriyama, Hideki

doi:10.1016/j.nut.2021.111277

Cited by 3 publications

(8 citation statements)

References 34 publications

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“…[17][18][19] Finally, this study did not assess lower extremity function, which may be associated with improved ADLs in patients with stroke. 5 This study identified the factors that contribute to higher medial gastrocnemius intramuscular adipose tissue content and its influence on functional outcomes. In addition, intramuscular adipose tissue in the medial gastrocnemius muscle on the nonparalyzed side was more strongly associated with functional outcomes than that on the paralyzed side.…”

Section: Discussionmentioning

confidence: 99%

“…Malnutrition and increased intramuscular adipose tissue have received increasing attention because they are related to poor functional prognosis, including diminished activities of daily living (ADLs), in patients after a stroke. [3][4][5] Malnutrition is associated with increased whole-body intramuscular adipose tissue deposition in older patients. 6 Furthermore, in patients who have experienced a stroke, increased quadricep intramuscular adipose tissue content is a predictor of poor ability to perform ADLs.…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…Malnutrition is associated with increased whole‐body intramuscular adipose tissue deposition in older patients 6 . Furthermore, in patients who have experienced a stroke, increased quadricep intramuscular adipose tissue content is a predictor of poor ability to perform ADLs 5 . A recent study showed that adequate energy intake 7 or exercise interventions 8 may effectively reduce the proportion of intramuscular adipose tissue.…”

Section: Introductionmentioning

confidence: 99%

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Association of medial gastrocnemius adiposity with poststroke severe malnutrition and functional performance of activities of daily living in older patients: A prospective analysis

et al. 2022

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Background: Relationships among medial gastrocnemius intramuscular adipose tissue, nutrition status, and functional outcomes of patients after a stroke are unknown. This study was conducted to determine the relationship between nutrition status and gastrocnemius intramuscular adipose tissue and whether medial gastrocnemius intramuscular adipose tissue affects functional outcomes of older patients after a stroke.Methods: This prospective cohort study included 217 patients with stroke. Nutrition status was evaluated by the Global Leadership Initiative on Malnutrition. The medial gastrocnemius intramuscular adipose tissue was assessed using ultrasound echographic intensity. Multivariate linear regression analysis was used to determine the relationship between nutrition status at admission and medial gastrocnemius intramuscular adipose tissue. Furthermore, we examined the influence of medial gastrocnemius intramuscular adipose tissue on the Functional Independence Measure (FIM)-motor score at discharge and FIM-motor efficiency, which indicates FIM-motor changes during the hospital stay.Results: Severe malnutrition had a positive influence on medial gastrocnemius intramuscular adipose tissue on the nonparalyzed side (β = 0.175; P = 0.044). Additionally, the medial gastrocnemius intramuscular adipose tissue on the nonparalyzed side was negatively correlated with the FIM-motor score at discharge (β = −0.102; P = 0.005) and FIM-motor efficiency (β = −0.273; P = 0.005).

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Association of medial gastrocnemius adiposity with poststroke severe malnutrition and functional performance of activities of daily living in older patients: A prospective analysis

et al. 2022

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“…Each item is scored on a 3-point ordinal scale, with 0 points for inability, 1 point for partial ability and 2 points for full ability to perform the required movement. 47 …”

Section: Exclusion Criteriamentioning

confidence: 99%

Effectiveness of cerebellar vermis intermittent theta-burst stimulation in improving trunk control and balance function for patients with subacute stroke: a randomised controlled trial protocol

et al. 2023

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IntroductionBalance impairments frequently occur after stroke. Achieving effective core trunk stability is the key to improving balance ability. However, there is still a lack of advanced well-defined rehabilitation protocols for balance improvement in patients with stroke. Intermittent theta-burst stimulation (iTBS) is a non-invasive brain activity modulation strategy that can produce long-term potentiation. The cerebellar vermis is a fundamental structure involved in balance and motor control. However, no study has demonstrated the therapeutic effect and potential mechanism of cerebellar vermis iTBS on balance after stroke.Methods and analysisThis study will be a prospective single-centre double-blind randomised controlled clinical trial with a 3-week intervention and 3-week follow-up. Eligible participants will be randomly allocated to the experimental group or the control group in a 1:1 ratio. After routine conventional physical therapy, patients in the experimental group will receive cerebellar vermis iTBS, whereas patients in the control group will receive sham stimulation. The overall intervention period will be 5 days a week for 3 consecutive weeks. The outcomes will be measured at baseline (T0), 3 weeks postintervention (T1) and at the 3-week follow-up (T2). The primary outcomes are Berg Balance Scale and Trunk Impairment Scale scores. The secondary outcomes are balance test scores via the Balance Master system, muscle activation of the trunk and lower limbs via the surface electromyography recordings, cerebral cortex oxygen concentrations measured via the resting-state functional near-infrared spectroscopy, Fugl-Meyer Assessment of Lower Extremity and Barthel index scores.Ethics and disseminationThis study was approved by the West China Hospital Clinical Trials and Biomedical Ethics Committee of Sichuan University. All participants will sign the informed consent form voluntarily. The results of this study will be published in peer-reviewed journals and disseminated at academic conferences.Trial registration numberChiCTR2200065369.

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The relationship between sarcopenic obesity and changes in quadriceps muscle thickness and echo intensity in patients with stroke

Maruyama,

Kagaya,

Kajiwara

et al. 2024

Topics in Stroke Rehabilitation

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Increased intramuscular adipose tissue of the quadriceps is related to decreased activities of daily living in patients who have had a stroke

Cited by 3 publications

References 34 publications

Association of medial gastrocnemius adiposity with poststroke severe malnutrition and functional performance of activities of daily living in older patients: A prospective analysis

Association of medial gastrocnemius adiposity with poststroke severe malnutrition and functional performance of activities of daily living in older patients: A prospective analysis

Effectiveness of cerebellar vermis intermittent theta-burst stimulation in improving trunk control and balance function for patients with subacute stroke: a randomised controlled trial protocol

The relationship between sarcopenic obesity and changes in quadriceps muscle thickness and echo intensity in patients with stroke

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