Increased Intracranial Pressure After Coronal Suturectomy in Craniosynostotic Rabbits

Mp, Mooney; Fellows-Mayle, Wendy; Hw, Losken; Dechant, Jason; Am, Burrows; Td, Smith; Cooper, Gregory; Pollack, Ian F.; Mj, Siegel

doi:10.1097/00001665-199903000-00003

Cited by 33 publications

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“…Premature coronal suture synostosis is associated with secondary deformities in the cranial vault and cranial base (Babler and Persing, 1982;Vannier, 1985, 1986;Burdi et al, 1986;Babler, 1989;Hoyte, 1989;Mooney et al, 1994b;Burrows et al, 1995;Smith et al, 1996), significantly elevated intracranial pressure (Renier, 1989;Gault et al, 1992;Mooney et al, 1998aMooney et al, , 1999Fellows-Mayle et al, 2000), and altered intracranial volume (Singhal et al, 1997;Hudgins et al, 1998;Mooney et al, 1998a,b;Camfield et al, 2000). These conditions may result in optic nerve compression and papilledema, and, if left uncorrected, optic atrophy, blindness (Miller, 2000), cognitive disabilities, and mental retardation (Kapp-Simmonds et al, 1993;Arnaud et al, 1995;Camfield et al, 2000;Persing and Jane, 2000).…”

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confidence: 99%

Rescue of coronal suture fusion using transforming growth factor‐beta 3 (Tgf‐β3) in rabbits with delayed‐onset craniosynostosis

et al. 2003

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Craniosynostosis results in cranial deformities and increased intracranial pressure, which pose extensive and recurrent surgical management problems. Developmental studies in rodents have shown that low levels of transforming growth factor-␤3 (Tgf-␤3) are associated with normal fusion of the interfrontal (IF) suture, and that Tgf-␤3 prevents IF suture fusion in a dose-dependent fashion. The present study was designed to test the hypothesis that Tgf-␤3 can also prevent or "rescue" fusing sutures in a rabbit model with familial craniosynostosis. One hundred coronal sutures from 50 rabbits with delayed-onset, coronal suture synostosis were examined in the present study. The rabbits were divided into five groups of 10 rabbits each: 1) sham controls, 2) bovine serum albumin (BSA, 500 ng) low-dose protein controls, 3) low-dose Tgf-␤3 (500 ng), 4) high-dose BSA (1,000 ng) controls, and 5) high-dose Tgf-␤3 (1,000 ng). At 10 days of age, radiopaque amalgam markers were implanted in all of the rabbits on either side of the coronal suture to monitor sutural growth. At 25 days of age, the BSA or Tgf-␤3 was combined with a slow-absorbing collagen vehicle and injected subperiosteally above the coronal suture. Radiographic results revealed that high-dose Tgf-␤3 rabbits had significantly greater (P Ͻ 0.05) coronal suture marker separation than the other groups. Histomorphometric analysis revealed that high-dose Tgf-␤3 rabbits also had patent coronal sutures and significantly (P Ͻ 0.01) greater sutural widths and areas than the other groups. The results suggest that there is a dose-dependent effect of TGF-␤3 on suture morphology and area in these rabbits, and that the manipulation of such growth factors may have clinical applications in the treatment of craniosynostosis. Anat Rec Part A 274A: 962-971, 2003.

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Rescue of coronal suture fusion using transforming growth factor‐beta 3 (Tgf‐β3) in rabbits with delayed‐onset craniosynostosis

et al. 2003

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“…Rabbits have been widely used as experimental model in studies of behavior of cranial sutures, intracranial pressure, craniometric variations, evolution of fixation materials, and distraction of craniofacial structures (Mabbutt and Kokich 1979;Persson, Roy et al 1979;Alberius and Selvik 1983a;Alberius, Selvik et al 1986;Persing, Babler et al 1986;Alberius, Malmberg et al 1990;Smith, Mooney et al 1996;Singhal, Mooney et al 1997;Losken, Mooney et al 1998;Mooney, Siegel et al 1999;Wendy, Fellows-Mayle et al 2000;Gewalli, Guimaraes-Ferreira et al 2001;Putz, Smith et al 2001;Abreu 2002;David, Gewalli et al 2002;Gosain, Santoro et al 2002;David, Proffer et al 2004;Guimarães-Ferreira, Miguéns et al 2004;Cooper, Singhal et al 2006;Cardoso, Cançado et al 2007;Davis, Windh et al 2008;Davis, Windh et al 2009). Cerebral growth curve of rabbit specimens is similar to those of newborn human children: craniofacial growth in rabbits is accelareted immediately after birth, progressively decreasing from two to thirty-four weeks of age (Alberius, Selvik et al 1986;Abreu 2002).…”

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confidence: 99%

Skull Expansion by Spring-Mediated Bone Regeneration

Dornelles¹,

Cardim²,

Alonso³

2012

Bone Regeneration

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“…Recently, we reported intracranial pressure data from synostosed rabbits in this colony. 21,22 In these preliminary studies, it was found that rabbits with early-onset coronal suture synostosis had significantly (p Ͻ 0.05) higher intracranial pressure than normal control rabbits at 25 days of age. However, by 42 days of age, intracranial pressure in synostosed rabbits decreased to normal levels without surgical intervention.…”

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“…However, by 42 days of age, intracranial pressure in synostosed rabbits decreased to normal levels without surgical intervention. 21,22 The present study was designed to further investigate these intracranial pressure changes by increasing the original sample size at 25 and 42 days of age and by adding two additional time points (10 and 84 days of age). In particular, the present study describes agerelated intracranial pressure changes in a homogeneous sample of rabbits with uncorrected, familial coronal suture synostosis and compares them with age-matched, normal control rabbits.…”

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Intracranial Pressure Changes in Craniosynostotic Rabbits

Fellows-Mayle

Mitchell

Losken

et al. 2004

Plastic and Reconstructive Surgery

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Cranial vault and brain deformities in individuals with craniosynostosis are thought to result, in part, from changes in intracranial pressure, but clinical findings are still inconclusive. The present study describes intracranial pressure changes in a rabbit model with naturally occurring, uncorrected coronal suture synostosis. Longitudinal and cross-sectional intracranial pressure data were collected from 241 New Zealand White rabbits, divided into four groups: normal controls (n = 81); rabbits with delayed-onset coronal suture synostosis (n = 78); rabbits with early-onset unilateral coronal suture synostosis (n = 32); and rabbits with early-onset bilateral coronal suture synostosis (n = 50). Epidural intracranial pressure measurements were obtained at 10, 25, 42, and 84 days of age using a NeuroMonitor microsensor transducer. Normal rabbits and rabbits with delayed-onset coronal suture and early-onset unilateral coronal suture synostosis showed a similar oscillating pattern of age-related changes in normal and head-down intracranial pressure from 10 to 84 days of age. In contrast, rabbits with early-onset bilateral coronal suture synostosis showed markedly elevated normal and head-down intracranial pressure levels from 10 to 25 days and showed a different pattern through 84 days. Results from one-way analysis of variance revealed significant (p < 0.01) group differences only at 25 days of age. Rabbits with early-onset bilateral coronal suture synostosis had significantly (p < 0.05) greater normal and head-down intracranial pressure (by 42 percent) than the other three groups. These results showed differing intracranial pressure compensations in rabbits with uncorrected multiple-suture synostosis compared with normal rabbits or rabbits with uncorrected single-suture synostosis, possibly through progressive cerebral atrophy and decreased intracranial volume, abnormal intracranial vascular patterns and blood volume, and/or differing cranial vault compensatory changes.

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Increased Intracranial Pressure After Coronal Suturectomy in Craniosynostotic Rabbits

Cited by 33 publications

References 0 publications

Rescue of coronal suture fusion using transforming growth factor‐beta 3 (Tgf‐β3) in rabbits with delayed‐onset craniosynostosis

Rescue of coronal suture fusion using transforming growth factor‐beta 3 (Tgf‐β3) in rabbits with delayed‐onset craniosynostosis

Skull Expansion by Spring-Mediated Bone Regeneration

Intracranial Pressure Changes in Craniosynostotic Rabbits

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