Increased intra-subject variability of neural activity during speech production in people with autism spectrum disorder

Murray, Elizabeth S. Heller; Segawa, Jennifer A.; Karahanoglu, F. Isik; Tocci, Catherine; Tourville, Jason A.; Nieto-Castañón, Alfonso; Tager–Flusberg, Helen; Manoach, Dara S.; Guenther, Frank H.

doi:10.1016/j.rasd.2022.101955

Cited by 4 publications

(5 citation statements)

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“…Of those 36 studies, 29 (81%) reported a deficit among autistic individuals on some measure of oromotor functioning. Twenty‐four studies (67% of instrumental studies) used acoustic analyses, five studies (14%) used facial motion tracking (Gladfelter & Goffman, 2018; Kothare et al, 2021; Manfredonia et al, 2019; Parish‐Morris et al, 2018; Samad et al, 2019), two studies (5%) used electromyography to measure muscle activation (Cattaneo et al, 2007; Pascolo & Cattarinussi, 2012), and two studies (5%) used magnetic resonance imaging of the brain (Chenausky, Kernbach, et al, 2017; Heller Murray et al, 2022). Each of the following methods was used in only one study: nasometry (Kasthurirathne et al, 2020), magnetoencephalography (Pang et al, 2016), and ultrasound tongue imaging (McKeever et al, 2022).…”

Section: Resultsmentioning

confidence: 99%

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Oromotor skills in autism spectrum disorder: A scoping review

et al. 2023

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Oromotor functioning plays a foundational role in spoken communication and feeding, two areas of significant difficulty for many autistic individuals. However, despite years of research and established differences in gross and fine motor skills in this population, there is currently no clear consensus regarding the presence or nature of oral motor control deficits in autistic individuals. In this scoping review, we summarize research published between 1994 and 2022 to answer the following research questions: (1) What methods have been used to investigate oromotor functioning in autistic individuals? (2) Which oromotor behaviors have been investigated in this population? and (3) What conclusions can be drawn regarding oromotor skills in this population? Seven online databases were searched resulting in 107 studies meeting our inclusion criteria. Included studies varied widely in sample characteristics, behaviors analyzed, and research methodology. The large majority (81%) of included studies report a significant oromotor abnormality related to speech production, nonspeech oromotor skills, or feeding within a sample of autistic individuals based on age norms or in comparison to a control group. We examine these findings to identify trends, address methodological aspects hindering cross‐study synthesis and generalization, and provide suggestions for future research.

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Section: Resultsmentioning

confidence: 99%

“…Two studies used MRI to examine the relationship between white matter tracts and speech improvement during intervention ( Chenausky, Kernbach, et al, 2017 ) and intra-subject variability in neural activity during speech production ( Heller Murray et al, 2022 ) among autistic individuals.…”

Section: Resultsmentioning

confidence: 99%

Oromotor skills in autism spectrum disorder: A scoping review

et al. 2023

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“…These differences in symptom severity, cognitive functioning, and sensory sensitivities can lead to diverse neural responses during auditory language comprehension tasks. This variability can confound the interpretation of group differences in studies involving individuals with autism (Heller Murray et al, 2022). Future research should aim to explore various subtypes of autism and individual differences more comprehensively, considering factors such as age, cognitive abilities, and sensory sensitivities.…”

Section: Discussionmentioning

confidence: 99%

Auditory language comprehension among children and adolescents with autism spectrum disorder: An ALE meta‐analysis of fMRI studies

Hua,

Hu,

Zeng

et al. 2023

Autism Research

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Difficulties in auditory language comprehension are common among children and adolescents with autism spectrum disorder. However, findings regarding the underlying neural mechanisms remain mixed, and few studies have systematically explored the overall patterns of these findings. Therefore, this study aims to systematically review and meta‐analyze the functional magnetic resonance imaging evidence of neural activation patterns while engaging in auditory language comprehension tasks among children and adolescents with autism. Using activation likelihood estimation, we conducted a series of meta‐analyses to investigate neural activation patterns during auditory language comprehension tasks compared to baseline conditions in autism and non‐autism groups and compared the activation patterns of the groups, respectively. Eight studies were included in the within‐group analyses, and seven were included in the between‐group analysis. The within‐group analyses revealed that the bilateral superior temporal gyrus was activated during auditory language comprehension tasks in both groups, whereas the left superior frontal gyrus and dorsal medial prefrontal cortex were activated only in the non‐autism group. Furthermore, the between‐group analysis showed that children and adolescents with autism, compared to those without autism, showed reduced activation in the right superior temporal gyrus, left middle temporal gyrus, and insula, whereas the autism group did not show increased activation in any of the regions relative to the non‐autism group. Overall, these findings contribute to our understanding of the potential neural mechanisms underlying difficulties in auditory language comprehension in children and adolescents with autism and provide practical implications for early screening and language‐related interventions for children and adolescents with autism.

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“…A diffusor tensor imaging study in adults with autism revealed a weaker connection between the ventral premotor cortex and the SMA ( Peeva et al, 2013 ). An fMRI study of activation during a speech production task (picture naming) showed no differences in brain activation between NT and autistic children, but increased intra-subject variability in brain activation in the autistic group ( Heller Murray et al, 2022 ). Taken together, these outcomes suggest brain and behavioral differences between autistic and NT groups during basic and complex oro-motor and phonemic tasks.…”

Section: Introductionmentioning

confidence: 95%