Increased intima thickness of the radial artery in individuals with prehypertension and hypertension

Myredal, Anna; Gan, Li; Osika, Walter; Friberg, Peter; Johansson, Mats

doi:10.1016/j.atherosclerosis.2009.09.017

Cited by 29 publications

(22 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We have demonstrated that high- resolution ultrasound allows measurement of very thin structures such as IMT of the rat carotid artery wall [50], and it has also been shown that measurement of the human radial artery IMT is feasible by this technique [24]. In the current study, we measured the intima media thickness in the radial artery and found no significant increase in IMT rad in the PHPT patients compared with controls.…”

Section: Discussionmentioning

confidence: 50%

“…Among PHPT patients with or without cardiovascular risk factors, IMT cca was found to be increased only in the group with risk factors [22]. Recently, echogenicity of the carotid intima media complex has been demonstrated to be related to cardiovascular risk factors [23], and the intima thickness of the radial artery (IMT rad ) has been shown to be increased in hypertension [24], but none of these indices have yet been studied in PHPT.…”

Section: Introductionmentioning

confidence: 98%

See 1 more Smart Citation

Arterial Structure and Function in Mild Primary Hyperparathyroidism Is Not Directly Related to Parathyroid Hormone, Calcium, or Vitamin D

et al. 2012

View full text Add to dashboard Cite

ObjectiveElevated levels of calcium and parathyroid hormone (PTH), characteristics of primary hyperparathyroidism (PHPT), may be associated with cardiovascular morbidity and mortality in the general population. We evaluated the possible vascular effects of these risk factors in patients with mild PHPT by using standard methods and new imaging techniques.DesignA prospective case-control study.Subjects and MethodsForty-eight patients with mild PHPT without any known cardiovascular risk factors were studied at baseline and at one year after parathyroidectomy (PTX) in comparison with 48 healthy age- and gender-matched controls. We measured biochemical variables, augmentation index (AIx), aortic pulse wave velocity (PWVao), radial (IMTrad) and common carotid artery (IMTcca) intima media thicknesses, and the grayscale median (IM-GSM) of the latter.ResultsNo significant differences were observed between PHPT patients and controls at baseline for AIx (28.6±12.2 vs. 27.7±12.8%), IMTrad (0.271±0.060 vs. 0.255±0.053 mm), IMTcca (0.688±0.113 vs. 0.680±0.135 mm), or IM-GSM (82.3±17.2 vs. 86.5±15.3), while PWVao was slightly higher in patients (8.68±1.50 vs. 8.13±1.55, p<0.05). Systolic blood pressure (SBP), calcium, and PTH were higher in patients compared with controls, and decreased after PTX, while vitamin D was lower in patients and increased after PTX. While AIx, PWVao, IMTrad, and IMTcca were related to SBP, neither correlated to vitamin D levels. Only PWVao correlated weakly to plasma PTH (r = 0.29, p<0.01) and ionized calcium (r = 0.22, p<0.05) but showed no relation when age and SBP were adjusted for.ConclusionWe found normal arterial function despite high calcium, PTH, and low vitamin D levels, in patients with mild PHPT without cardiovascular risk factors. The cardiovascular risk associated with low vitamin D and/or high PTH and calcium levels may be explained by their coupling to blood pressure and other risk factors rather than direct effects on arterial structure.

show abstract

Section: Discussionmentioning

confidence: 50%

Section: Introductionmentioning

confidence: 98%

Arterial Structure and Function in Mild Primary Hyperparathyroidism Is Not Directly Related to Parathyroid Hormone, Calcium, or Vitamin D

et al. 2012

View full text Add to dashboard Cite

show abstract

“…While hypertension is a manifestation of loss of vascular integrity and a precursor for atherosclerosis, the latter has been shown to be present even in the early development of hypertension when blood pressure is slightly elevated. 35 In our study, a total of 6.6% of the participants had non-optimal SBP (≥140 mmHg) and nearly 8% of the participants had non-optimal DBP (≥90 mmHg). When we adjusted for blood pressure instead of hypertension, the associations were only slightly attenuated.…”

Section: Discussionmentioning

confidence: 51%

Intima-Media Thickness and Cognitive Function in Stroke-Free Middle-Aged Adults

Hazzouri

Vittinghoff

Reis

et al. 2015

Stroke

View full text Add to dashboard Cite

Background and Purpose The relationship between carotid artery intima media thickness (IMT) and cognitive function in midlife remains relatively unexplored. We examined the association between IMT and cognitive function in a middle-aged epidemiologic cohort of 2,747 stroke-free participants. Methods At the Year 20 visit (our study baseline), participants from the Coronary Artery Risk Development in Young Adults study had IMT measured by ultrasound at the common carotid artery. Five years later, participants completed a cognitive battery consisting of the Rey Auditory-Verbal Learning Test of verbal memory, the Digit Symbol Substitution Test of processing speed, and the Stroop test of executive function. We transformed cognitive scores into standardized z-scores, with negative values indicating worse performance. Results Mean age at baseline was 45.3 years (SD=3.6). Greater IMT (per 1SD difference of 0.12mm) was significantly associated with worse performance on all cognitive tests (z-scores) in unadjusted linear regression models (Verbal Memory=−0.16, 95%CI=−0.20 to −0.13; Processing Speed=−0.23, 95%CI=−0.27 to −0.19; and Executive Function=−0.17, 95%CI= −0.20 to −0.13). In models adjusted for socio-demographics and vascular risk factors that lie earlier in the causal pathway, greater IMT remained negatively associated with processing speed (−0.06,95%CI=−0.09 to −0.02; p=0.003) and borderline associated with executive function (−0.03, 95%CI=−0.07 to 0.00; p=0.07) but not with verbal memory. Conclusions We observed an association between greater IMT and worse processing speed – a key component of cognitive functioning- at middle-age above and beyond traditional vascular risk factors. Efforts targeted at preventing early stages of atherosclerosis may modify the course of cognitive aging.

show abstract

“…The reference for luminal diameter in healthy subjects is 1.7 ± 0.48 mm and for intima medial thickness is 0.21 ± 0.053 mm. 12 Blood flow parameters remained unchanged in all patients during the observation period.…”

Section: Resultsmentioning

confidence: 85%

Upper-Extremity Transplantation Using a Cell-Based Protocol to Minimize Immunosuppression

et al. 2013

View full text Add to dashboard Cite

Objective To minimize maintenance immunosuppression in upper-extremity transplantation to favor the risk-benefit balance of this procedure. Background Despite favorable outcomes, broad clinical application of reconstructive transplantation is limited by the risks and side effects of multidrug immunosuppression. We present our experience with upper-extremity transplantation under a novel, donor bone marrow (BM) cell-based treatment protocol (“Pittsburgh protocol”). Methods Between March 2009 and September 2010, 5 patients received a bilateral hand (n = 2), a bilateral hand/forearm (n = 1), or a unilateral (n = 2) hand transplant. Patients were treated with alemtuzumab and methylprednisolone for induction, followed by tacrolimus monotherapy. On day 14, patients received an infusion of donor BM cells isolated from 9 vertebral bodies. Comprehensive follow-up included functional evaluation, imaging, and immunomonitoring. Results All patients are maintained on tacrolimus monotherapy with trough levels ranging between 4 and 12 ng/mL. Skin rejections were infrequent and reversible. Patients demonstrated sustained improvements in motor function and sensory return correlating with time after transplantation and level of amputation. Side effects included transient increase in serum creatinine, hyperglycemia managed with oral hypoglycemics, minor wound infection, and hyperuricemia but no infections. Immunomonitoring revealed transient moderate levels of donor-specific antibodies, adequate immunocompetence, and no peripheral blood chimerism. Imaging demonstrated patent vessels with only mild luminal narrowing/occlusion in 1 case. Protocol skin biopsies showed absent or minimal perivascular cellular infiltrates. Conclusions Our data suggest that this BM cell-based treatment protocol is safe, is well tolerated, and allows upper-extremity transplantation using low-dose tacrolimus monotherapy.

show abstract

Increased intima thickness of the radial artery in individuals with prehypertension and hypertension

Cited by 29 publications

References 21 publications

Arterial Structure and Function in Mild Primary Hyperparathyroidism Is Not Directly Related to Parathyroid Hormone, Calcium, or Vitamin D

Arterial Structure and Function in Mild Primary Hyperparathyroidism Is Not Directly Related to Parathyroid Hormone, Calcium, or Vitamin D

Intima-Media Thickness and Cognitive Function in Stroke-Free Middle-Aged Adults

Upper-Extremity Transplantation Using a Cell-Based Protocol to Minimize Immunosuppression

Contact Info

Product

Resources

About