Increased intima-media thickness is not associated with stiffer arteries in children

Weberruß, Heidi; Pirzer, Raphael; Böhm, Birgit; Elmenhorst, Julia; Pozza, Robert Dalla; Netz, Heinrich; Oberhoffer, Renate

doi:10.1016/j.atherosclerosis.2015.06.045

Cited by 25 publications

(36 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This subsample of 46 obese children and 46 sex- and age-matched controls was part of the prevention project “Sternstunden der Gesundheit”, a cross-sectional prospective study to establish reference values for cIMT and distensibility measures [ 15 ]. Out of the total study population ( n = 1017 children), measurements of intima-media thickness and arterial distensibility were performed in 656 children (353 girls) of which 46 children (7 %) were obese (27 girls).…”

Section: Resultsmentioning

confidence: 99%

“…Data collection was part of the prevention project “Sternstunden der Gesundheit”, a prospective cross-sectional study conducted from October 2012 to July 2013 in the area of Berchtesgadener Land, Germany. 1017 healthy children (483 boys/534 girls) aged 7–18 were examined to establish reference values for cIMT and parameters of arterial distensibility [ 15 ]. Children had no history of chronic disease or signs of acute infection.…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Intima-media thickness and arterial function in obese and non-obese children

et al. 2015

Self Cite

View full text Add to dashboard Cite

BackgroundObesity is an independent cardiovascular risk factor that contributes to the development of atherosclerosis. Subclinical forms of the disease can be assessed via sonographic measurement of carotid intima-media thickness (cIMT) and distensibility – both may already be altered in childhood. As childhood obesity increases to an alarming extent, this study compares vascular data of obese with normal weight boys and girls to investigate the influence of obesity on cIMT and distensibility of the carotid arteries.MethodscIMT and distensibility of 46 obese children (27 girls) aged 7–17 years were compared with measures of 46 sex- and age-matched normal weight controls. cIMT and distensibility were measured by B- and M-mode ultrasound and expressed as standard deviation scores (SDS). Arterial distensibility was defined by arterial compliance (AC), elastic modulus (Ep), stiffness index β (β), and local pulse wave velocity β (PWV β).ResultsObese girls had significantly stiffer arteries compared with normal weight girls (Ep SDS 0.64 ± 1.24 vs. 0 ± 1.06, β SDS 0.6 ± 1.17 vs. -0.01 ± 1.06 p < .01, PWV β 0.54 ± 1.2 vs. -0.12 ± 1.05 p < .05). No significant differences were observed for boys. In multiregression analysis, BMI significantly influenced Ep, β and PWV β but not cIMT and AC.ConclusionsObese girls seemed to be at higher cardiovascular risk than boys, expressed by stiffer arteries in obese girls compared with normal weight girls. Overall, BMI negatively influenced parameters of arterial stiffness (Ep, β and PWV β) but not compliance or cIMT.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Intima-media thickness and arterial function in obese and non-obese children

et al. 2015

Self Cite

View full text Add to dashboard Cite

show abstract

“…Data collection was part of the prevention project "Sternstunden der Gesundheit", a cross-sectional prospective study conducted from October, 2012 to July, 2013 in Berchtesgadener Land, Germany. Healthy children (n = 1017, 483 boys/534 girls) aged 7-17 years were included to establish reference percentiles for carotid intima-media thickness and distensibility measures 28 and to investigate cardiorespiratory fitness and strength. The study was approved by the ethics committee of the Technische Universität München (5490/12), and informed written consent was obtained from parents of children younger than 14 years of age and from both parents and children ⩾ 14 years.…”

Section: Methodsmentioning

confidence: 99%

“…To control for age differences in parameters, sex-and age-specific standard deviation scores were applied in this analysis. 28 Data are expressed as mean value ± standard deviation; a p-value of <0.05 was considered to be statistically significant.…”

Section: Methodsmentioning

confidence: 99%

Reduced arterial stiffness in very fit boys and girls

et al. 2016

Self Cite

View full text Add to dashboard Cite

Low cardiorespiratory fitness is associated with higher cardiovascular risk, whereas high levels of cardiorespiratory fitness protect the cardiovascular system. Carotid intima-media thickness and arterial distensibility are well-established parameters to identify subclinical cardiovascular disease. Therefore, this study investigated the influence of cardiorespiratory fitness and muscular strength on carotid intima-media thickness and arterial distensibility in 697 children and adolescents (376 girls), aged 7-17 years. Cardiorespiratory fitness and strength were measured with the test battery FITNESSGRAM; carotid intima-media thickness, arterial compliance, elastic modulus, stiffness index β, and pulse wave velocity β were assessed by B- and M-mode ultrasound at the common carotid artery. In bivariate correlation, cardiorespiratory fitness was significantly associated with all cardiovascular parameters and was an independent predictor in multivariate regression analysis. No significant associations were obtained for muscular strength. In a one-way variance analysis, very fit boys and girls (58 boys and 74 girls>80th percentile for cardiorespiratory fitness) had significantly decreased stiffness parameters (expressed in standard deviation scores) compared with low fit subjects (71 boys and 77 girls<20th percentile for cardiorespiratory fitness): elastic modulus -0.16±1.02 versus 0.19±1.17, p=0.009; stiffness index β -0.15±1.08 versus 0.16±1.1, p=0.03; and pulse wave velocity β -0.19±1.02 versus 0.19±1.14, p=0.005. Cardiorespiratory fitness was associated with healthier arteries in children and adolescents. Comparison of very fit with unfit subjects revealed better distensibility parameters in very fit boys and girls.

show abstract

“…[12,13] Furthermore, attempts to correlate increased CIMT and increased stiffness are not always defi nitive. [14,15] Exposure to second-hand smoke (SHS) has also been associated with development of cardiovascular risk factors. [16] SHS exposure, like primary smoking, has also been positively correlated with CIMT in both a dosedependent manner and based on experiences in early childhood.…”

Section: Introductionmentioning

confidence: 99%

Comparison of ultrasound-measured properties of the common carotid artery to tobacco smoke exposure in a cohort of Indonesian patients

Yu¹,

Hasjim²,

Yu³

et al. 2017

World Journal of Emergency Medicine

View full text Add to dashboard Cite

BACKGROUND:The purpose of this study was to use point-of-care ultrasound (POCUS) to investigate the relationship between tobacco smoke exposure and the characteristics of the common carotid artery (CCA). The effect of both primary and secondary smoking on CCA properties was evaluated. METHODS:We performed a prospective cross-sectional study across 20 primary care clinics in Bandung, West Java, Indonesia in July 2016. Point of care ultrasound was performed on a convenience sample of Indonesian patients presenting to clinic. The CCA wall stiffness and carotid intima-media thickness (CIMT) were measured during diastole and systole. These measurements were correlated with smoke exposure and cardiovascular disease. RESULTS:We enrolled 663 patients in the study, with 426 patients enrolled in the smoking category and 237 patients enrolled in the second-hand smoke category. There was an overall positive correlation with the measured lifestyle factors and the ultrasound-measured variables in the group of individuals who smoked. For all variables, age seemed to contribute the most out of all of the lifestyle factors for the positive changes in CIMT and CCA wall stiffness. CONCLUSION: Our data yielded correlations between CCA properties and cardiovascular risk, as well as between CIMT and arterial stiffness. We were also able to demonstrate an increase in thickness of the CIMT in patients who have been exposed by tobacco through the use of ultrasound. Further large scale studies comparing patients with multiple cardiac risk factors need to be performed to confi rm the utility of ultrasound fi ndings of cardiovascular disease and stroke.

show abstract

Increased intima-media thickness is not associated with stiffer arteries in children

Cited by 25 publications

References 48 publications

Intima-media thickness and arterial function in obese and non-obese children

Intima-media thickness and arterial function in obese and non-obese children

Reduced arterial stiffness in very fit boys and girls

Comparison of ultrasound-measured properties of the common carotid artery to tobacco smoke exposure in a cohort of Indonesian patients

Contact Info

Product

Resources

About