Increased intestinal phosphate absorption, an often‐overlooked effect of vitamin D

Alexander, R. Todd

doi:10.1113/jp281095

Cited by 2 publications

(1 citation statement)

References 5 publications

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“…These results were similar using the ileal ligated loop method. As observed in the accompanying commentary [13], this study provides evidence that the effect of calcitriol to increase intestinal phosphorus absorption is entirely through its effect on transcellular absorption, not paracellular, and that this is completely mediated by NaPi-2b.…”

Section: Transcellular Versus Paracellular Pathways Of Intestinal Pho...supporting

confidence: 74%

Intestinal phosphorus absorption: recent findings in translational and clinical research

Gallant

Vorland

2021

Current Opinion in Nephrology &Amp; Hypertension

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Purpose of reviewThe purpose of this review is to discuss recent findings in intestinal phosphorus absorption pathways, particularly the contributions of paracellular versus transcellular absorption, and the differential findings from studies using in vitro versus in vivo techniques of assessing phosphorus absorption in experimental animal studies.Recent findingsExperimental animal studies show that in vivo effects of low phosphorus diets, 1,25D, and chronic kidney disease on intestinal phosphorus absorption efficiency contradict effects previously established ex vivo/in vitro. Recent in vivo studies also suggest that the paracellular pathway accounts for the majority of phosphorus absorption in animals across very low to high luminal phosphate concentrations. The data from experimental animal studies correspond to recent human studies showing the effectiveness of targeted inhibition of paracellular phosphate absorption. Additionally, recent human studies have demonstrated that NaPi-2b inhibition alone does not appear to be effective in lowering serum phosphate levels in patients with chronic kidney disease. Pursuit of other transcellular phosphate transporter inhibitors may still hold promise.SummaryIn vivo animal and human studies have added to our understanding of intestinal phosphorus absorption pathways, regulation, and mechanisms. This is beneficial for developing effective new strategies for phosphate management in patients with chronic kidney disease.

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Section: Transcellular Versus Paracellular Pathways Of Intestinal Pho...supporting

confidence: 74%

Intestinal phosphorus absorption: recent findings in translational and clinical research

Gallant

Vorland

2021

Current Opinion in Nephrology &Amp; Hypertension

View full text Add to dashboard Cite

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ABCG2 plays a central role in the dysregulation of 25-hydrovitamin D in Crohn's disease

Peng¹,

Song²,

Zhu³

et al. 2023

The Journal of Nutritional Biochemistry

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Increased intestinal phosphate absorption, an often‐overlooked effect of vitamin D

Cited by 2 publications

References 5 publications

Intestinal phosphorus absorption: recent findings in translational and clinical research

Intestinal phosphorus absorption: recent findings in translational and clinical research

ABCG2 plays a central role in the dysregulation of 25-hydrovitamin D in Crohn's disease

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