Increased intestinal permeability in bronchial asthma

Benard, Anne; Desreumeaux, Pierre; Huglo, D.; Hoorelbeke, Anne; Tonnel, André‐Bernard; Wallaert, B.

doi:10.1016/s0091-6749(96)70181-1

Cited by 91 publications

(81 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Previous studies have examined the interaction between bronchial and intestinal mucosae in humans. The authors previously demonstrated that the intestinal permeability to chromium-51 labelled ethylenediamine tetraacetic acid (CrEDTA) was significantly higher in patients with asthma than in patients with chronic obstructive pulmonary disease or controls [24]. In addition, the intestinal mucosa in asthmatic patients exhibited "airway-like" pathological abnormalities, including a significant accumulation of mononuclear cells, of eosinophils and of inflammatory cells expressing interleukins 3 and 5 and granulocyte-macrophage colony stimulating factor in the lamina propria [1].…”

Section: Discussionmentioning

confidence: 99%

Increased frequency of asymptomatic bronchial hyperresponsiveness in nonasthmatic patients with food allergy

Thaminy¹,

Lamblin²,

Pérez³

et al. 2000

Eur Respir J

View full text Add to dashboard Cite

Subclinical inflammation in gut mucosa has been demonstrated in bronchial asthma suggesting the whole mucosal system is involved in allergic diseases. The presence of subclinical bronchial involvement was assessed by nonspecific bronchial hyperresponsiveness (BHR) in nonasthmatic patients with food allergy (FA). BHR was studied in 35 patients with various manifestations of FA without food‐induced asthma. Sixteen had a previous history of asthma and/or rhinitis to aeroallergens (group A), whereas 19 patients (group B) did not. BHR was defined by a provocative dose causing a 20% fall in forced expiratory volume in one second of (PC20) <8 mg·mL‐1 of methacholine. Asymptomatic BHR occurred frequently in nonasthmatic patients with FA (10 of 19, 53%); this did not significantly differ from patients with FA and a previous history of asthma and/or rhinitis to aeroallergens (13 of 16, 81%). PC20 was significantly lower in group A (1.84±0.53 mg·mL‐1) than in group B (3.35±0.74 mg·mL‐1; p<0.05). The number of patients with positive skin tests to aeroallergens was similar between groups. Sequential evaluation, performed 1 year after initial evaluation, in 7 non‐asthmatic patients (group B) demonstrated a similar level of BHR. The present study demonstrated that BHR is a frequent finding in nonasthmatic patients with food allergy which may be due, at least in part, to a subclinical inflammatory process in the bronchi.

show abstract

Section: Discussionmentioning

confidence: 99%

Increased frequency of asymptomatic bronchial hyperresponsiveness in nonasthmatic patients with food allergy

Thaminy¹,

Lamblin²,

Pérez³

et al. 2000

Eur Respir J

View full text Add to dashboard Cite

show abstract

“…The mechanisms by which airway inflammation and alterations in airway function are maintained remain incompletely understood. Because wheezing can also be triggered by food challenges in some asthmatic children, increased intestinal permeability of asthmatics (14,76) may play a role in susceptibility to environmental allergens (87). Intestinal permeability can be altered as a result of exposure to antigens (82,87).…”

Section: Asthmamentioning

confidence: 99%

Zonulin and Its Regulation of Intestinal Barrier Function: The Biological Door to Inflammation, Autoimmunity, and Cancer

Fasano

2011

Physiological Reviews

769

633

View full text Add to dashboard Cite

The primary functions of the gastrointestinal tract have traditionally been perceived to be limited to the digestion and absorption of nutrients and to electrolytes and water homeostasis. A more attentive analysis of the anatomic and functional arrangement of the gastrointestinal tract, however, suggests that another extremely important function of this organ is its ability to regulate the trafficking of macromolecules between the environment and the host through a barrier mechanism. Together with the gut-associated lymphoid tissue and the neuroendocrine network, the intestinal epithelial barrier, with its intercellular tight junctions, controls the equilibrium between tolerance and immunity to non-self antigens. Zonulin is the only physiological modulator of intercellular tight junctions described so far that is involved in trafficking of macromolecules and, therefore, in tolerance/immune response balance. When the finely tuned zonulin pathway is deregulated in genetically susceptible individuals, both intestinal and extraintestinal autoimmune, inflammatory, and neoplastic disorders can occur. This new paradigm subverts traditional theories underlying the development of these diseases and suggests that these processes can be arrested if the interplay between genes and environmental triggers is prevented by reestablishing the zonulin-dependent intestinal barrier function. This review is timely given the increased interest in the role of a “leaky gut” in the pathogenesis of several pathological conditions targeting both the intestine and extraintestinal organs.

show abstract

“…Immunological dysfunctions triggered by environmental factors are a common element in the pathogenesis of both IBD and airway diseases, such as asthma and chronic obstructive pulmonary disease (COPD). Furthermore, pulmonary involvement, in its multiple forms [5], is one of the extra-intestinal manifestations of IBD, while an increased intestinal permeability was described in asthmatic patients [6].…”

Section: Introductionmentioning

confidence: 99%

Increased incidence of inflammatory bowel disease in Québec residents with airway diseases

et al. 2014

View full text Add to dashboard Cite

The objective of the study was to assess whether the incidences of Crohn's disease and ulcerative colitis are increased in patients with asthma and chronic obstructive pulmonary disease (COPD) compared to the general population.A population-based retrospective cohort study was conducted using the administrative health databases of Québec, Canada. Incidences of Crohn's disease and ulcerative colitis among patients with asthma and COPD were assessed for the 2001-2006 period.In total, 136 178 subjects with asthma and 143 904 subjects with COPD were identified. The average incidence of Crohn's disease and ulcerative colitis was 23.1 and 8.8 per 100 000 person-years among asthmatic patients; in the COPD cohort there were 26.2 Crohn's disease cases and 17 ulcerative colitis cases per 100 000 person-years. The incidence of Crohn's disease in asthma and COPD patients was 27% and 55% higher than in the general population of Québec; the incidence of ulcerative colitis was 30% higher among COPD patients compared to the general population.Incidence of inflammatory bowel disease was significantly increased in asthma and COPD patients compared to the general population of Québec. Incidence rates were particularly high in patients with COPD. Awareness of an association between airway diseases and inflammatory bowel disease in older age groups may play an important role in earlier detection of bowel disease and in the therapeutic management of such patients. @ERSpublications Patients with airway diseases have a higher incidence of inflammatory bowel disease than the general population

show abstract

Increased intestinal permeability in bronchial asthma

Cited by 91 publications

References 26 publications

Increased frequency of asymptomatic bronchial hyperresponsiveness in nonasthmatic patients with food allergy

Increased frequency of asymptomatic bronchial hyperresponsiveness in nonasthmatic patients with food allergy

Zonulin and Its Regulation of Intestinal Barrier Function: The Biological Door to Inflammation, Autoimmunity, and Cancer

Increased incidence of inflammatory bowel disease in Québec residents with airway diseases

Contact Info

Product

Resources

About