Increased interleukin-6 in collected drainage blood after total knee arthroplasty: An association with febrile reactions during retransfusion

Händel, M.; Winkler, J.; Hörnlein, Rainer F; Northoff, Hinnak; Heeg, Peter; Teschner, Martin; Sell, Stefan

doi:10.1080/00016470152846600

Cited by 36 publications

(40 citation statements)

References 11 publications

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“…The purpose of a re-transfusion system of autologous blood from the wound is to reduce the need for homologous blood transfusion. Re-transfusion of autologous blood as well as transfusion of homologous blood may influence the patient's immune system [8]. The reported results of studies where postoperative wound drainage is not used, vary considerably.…”

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confidence: 81%

Transfusion of autologous blood from reinfusion systems in total knee arthroplasty

Martin

Strempel

2006

International Orthopaedics (SICOT)

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After total knee arthroplasty (TKA) the technique of wound management is not standardised. In this prospective study the efficacy of autologous blood reinfusion from the wound was investigated. One hundred patients (100 TKAs) were enrolled in this sequential cohort study. In one-half of the operations, a reinfusion system with suction and in the other half one wound drain without suction were used. Blood loss, transfusion requirements, range of motion, Insall scores and the incidence of complications were studied. The use of a reinfusion system did not decrease the homologous transfusion requirements. The blood loss in the group with a suction drainage system was significantly higher. Our experiences since May 2002 with one drain without suction in 787 consecutive TKAs confirm all findings of the current study.Résumé Après une arthroplastie totale du genou le problème des pertes sanguines, n'est pas aujourd'hui un problème standardisé. Lors d'une étude prospective, l'efficacité de l'autotransfusion a été appréciée. Cent prothèses totales ont été enrôlées dans une cohorte. La moitié d'entre eux ont bénéficié d'une retransfusion des pertes sanguines du redon et pour l'autre moitié, le redon simple a été utilisé, sans récupération du sang postopératoire. Les pertes de sang, la nécessité de transfusion, la mobilité, le score Insall et les complications ont été étudiés. L'utilisation d'une récupération avec retransfusion du sang post-opératoire ne diminue pas le nombre de transfusions homologues. Les pertes sanguines dans le groupe avec drainage simple sont plus importantes. Notre expérience depuis mai 2002 avec l'utilisation d'un drain sans aspiration dans 787 prothèses totales du genou consécutives confirment ses données. IntroductionThere is no generally accepted or standardised technique for postoperative wound management after total knee arthroplasty (TKA) [17]. Some surgeons use a reinfusion system of autologous blood [19,23] and others use closed suction drainage [11] following elective knee arthroplasty. Theoretically, a wound drain should minimise postoperative haematoma and all of the complications with which it is associated [4]. However, wound drains may potentially introduce different complications including infection [3,25]. The purpose of a re-transfusion system of autologous blood from the wound is to reduce the need for homologous blood transfusion. Re-transfusion of autologous blood as well as transfusion of homologous blood may influence the patient's immune system [8]. The reported results of studies where postoperative wound drainage is not used, vary considerably. There are some studies showing a higher and others no higher complication rates compared with patient groups managed with closed suction drain systems.The purpose of this study was to compare the method of re-transfusion of the collected autologous unwashed blood from the wound with a closed non-suction drainage system. Materials and methodsPrimary total knee replacements were performed in 100 patients. The following knee pros...

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confidence: 81%

Transfusion of autologous blood from reinfusion systems in total knee arthroplasty

Martin

Strempel

2006

International Orthopaedics (SICOT)

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“…Although the washing procedure in our study reduced IL-6 concentrations by 89% in the liver resection group and by 62% in the aortic surgery group, IL-6 concentrations in the autologous RBC were still higher than those found in healthy subjects [13]. Retransfusion of drainage blood with IL-6 concentrations 60 times higher than those measured in our study did not result in febrile reactions in orthopedic patients [14]. In general, the CS eliminates inflammatory mediators through the washing process.…”

Section: Discussionmentioning

confidence: 53%

Is cell salvage safe in liver resection? A pilot study

Schmidt

Sues

Siegel

et al. 2009

Journal of Clinical Anesthesia

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“…Several studies have demonstrated an increase in concentration of complement split products and cytokines levels such as C3a, SC5b, TNF-α, IL-1α, IL-1β, IL-6 and IL-8 in shed blood, but only elevated IL-6 in plasma following transfusion [18,19]. One of the most common side effects of autologous blood transfusion is febrile reaction and it has been found to be related to higher concentration of IL-6 in shed blood [20]. We did not find any such side effects with our study.…”

Section: Discussionmentioning

confidence: 99%

Autologous Blood Transfusion Reduces Post-Operative Blood Transfusion Following Total Hip Replacement

Moideen¹,

McMillan²,

Zafiropoulos³

2017

J Arthritis

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Increased interleukin-6 in collected drainage blood after total knee arthroplasty: An association with febrile reactions during retransfusion

Abstract: Sell (2001) Increased interleukin-6 in collected drainage blood after total knee arthroplasty: An association with febrile reactions during retransfusion, Acta Orthopaedica Scandinavica, 72:3, 270-272,

Cited by 36 publications

References 11 publications

Transfusion of autologous blood from reinfusion systems in total knee arthroplasty

Transfusion of autologous blood from reinfusion systems in total knee arthroplasty

Is cell salvage safe in liver resection? A pilot study

Autologous Blood Transfusion Reduces Post-Operative Blood Transfusion Following Total Hip Replacement

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