Increased interleukin 5 production in eosinophilic S?zary syndrome: Regulation by interferon alfa and interleukin 12

Immunopathogenesis and therapy of cutaneous T cell lymphoma

“…Peripheral eosinophilia has been determined to be an independent marker for poor prognosis and disease progression (58). In one study, peripheral blood cells from patients with SS and eosinophilia produced markedly higher levels of IL-5 upon stimulation than did the cells of patients or normal volunteers without eosinophilia (59). It is noteworthy that in this study, culture of the patients' cells with either recombinant IFN-α or IL-12 significantly inhibited the excess production of IL-5.…”

Prognostic Value of Blood Eosinophilia in Primary Cutaneous T-Cell Lymphomas

“…Such research might help to identify subgroups of patients who might benefit from immunotherapeutic approaches such as interleukin 12, interleukin 2, and interferon gamma, which are likely to correct the abnormal cytokine production observed in CTCL. 25,[43][44][45][46][47] However, our results strongly suggest that blood eosinophilia at baseline should now be considered a prognostic factor of poor outcome in patients with CTCL.…”

The Use of Interferons in the Treatment of Cutaneous T-Cell Lymphoma

“…34 In addition, culturing the peripheral blood of patients with SS with recombinant IFN alfa was observed to significantly inhibit the excess production of IL-5, a cytokine that stimulates the proliferation of eosinophils. 31 As noted above, peripheral eosinophilia has been associated with worse prognosis and adverse events. Fig.…”