Increased interleukin-4 and decreased interferon-γ levels in serum of children with asthma

Lama, Manoj; Chatterjee, Mridula; Nayak, Chittaranjan; Chaudhuri, Tapas Kumar

doi:10.1016/j.cyto.2011.05.011

Cited by 38 publications

(31 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Accumulating evidence has shown that inflammatory responses of asthma are mediated by T-helper type 2 (Th2) cytokines including IL-4, IL-5, IL-9, and IL-13, which are critical for the synthesis of immunoglobulin IgE, the switch of T-helper cells toward the Th2 phenotype, and the survival of eosinophils 3. It has been suggested that alterations in cytokines network, including the overproduction of Th2 cytokines (interleukin [IL]-4, IL-5, and IL-13), the reduction in Th1 cytokines (interferon [IFN]-γ and IL-2), and abnormalities of IL-17, TGF-β, and thymic stromal lymphopoietin (TSLP), are involved in pathophysiology of asthma 4. A variety of innate immune cells, such as dendritic cells, mast cells, and epithelial cells, also contribute to the airway inflammation of asthma.…”

Section: Introductionmentioning

confidence: 99%

Deguelin Attenuates Allergic Airway Inflammation via Inhibition of NF-κb Pathway in Mice

et al. 2017

View full text Add to dashboard Cite

Asthma is a chronic respiratory disease characterized by airway inflammation and remodeling, resulting in a substantial economic burden on both patients and society. Deguelin, a constituent of the Leguminosae family, exhibits anti-proliferative and anti-inflammatory activities in cancer mice models via inhibiting phosphatidylinositol 3-kinases and the NF-κB pathway. We demonstrated that deguelin effectively reduced OVA-induced inflammatory cell recruitment, decreased lung tissue inflammation and mucus production, suppressed airway hyperresponsiveness, and inhibited serum immunoglobulin and Th2 cytokine levels in a dose-dependent manner in asthmatic mice. In addition, we found that deguelin reduced inflammatory gene expressions both in vivo and in vitro, which were closely associated with activation of the NF-κB signaling pathway. Thus, we further explored the underlying mechanisms of deguelin in normal human bronchial epithelial cells (BEAS-2B). Our results suggested that deguelin inhibited NF-κB binding activity by enhancing the ability of IκBα to maintain NF-κB in an inactive form in the cytoplasm and preventing the TNF-α induced translocation of p65 to the nucleus. In conclusion, our research indicates that deguelin attenuates allergic airway inflammation via inhibition of NF-κB pathway in mice model and may act as a potential therapeutic agent for patients with allergic airway inflammation.

show abstract

Section: Introductionmentioning

confidence: 99%

Deguelin Attenuates Allergic Airway Inflammation via Inhibition of NF-κb Pathway in Mice

et al. 2017

View full text Add to dashboard Cite

show abstract

“…In our previous study, we investigated serum levels of IL-4 and IFN-c in 48 asthmatic and 32 control subjects [7].…”

Section: Determination Of Serum Level Of Interleukin-4mentioning

confidence: 99%

Total Serum Immunoglobulin E in Children with Asthma

2012

View full text Add to dashboard Cite

Immunoglobulin (Ig) E has been shown to be a major contributing factor for the development of bronchial hyperresponsiveness in asthma. An elevation in serum IgE levels contributes to asthma and is considered a potent predictor of the development of asthma. The objectives of the present study were to estimate the levels of total serum IgE in asthmatic and healthy control subjects and to investigate the relationship of various demographic and clinical characteristics with the total serum IgE level in asthmatics. We measured the levels of total serum IgE using the ELISA kits (AccuBind, Monobind Inc., USA). The relevant demographic and clinical data were obtained using the questionnaire. The results showed that asthmatic children had significantly elevated level of total serum IgE compared to that of the healthy controls. The levels of total IgE and IL-4 in sera of 44 asthmatic children showed a significant positive correlation. Total serum IgE [150 IU/ mL was found to be significantly associated with the age, exposure to cigarette smoke, and raised eosinophil count in asthmatic children. In conclusion, the elevated level of total serum IgE may demonstrate the allergic etiology of asthma in the subjects studied.

show abstract

“…In addition, IL-4Ra as the type I receptor confers specificity for IL-4 binding and signal transduction (Miloux et al, 1997). Conversely, IFN-c, a predominant cytokine produced by Th1 and Tc1 cells, plays an important role in suppressing Th2-mediated responses, and has been shown to be a major regulatory cytokine that inhibits the proliferation of Th2 cells in vitro and antagonizes the in vivo Th2-type responses such as IL-4-dependent IgE antibody production (Heaton et al, 2005;Lama et al, 2011). Thus, the IL-4/IFN-c ratio can reflect the ratio of Th1/Th2 differentiation.…”

Section: Discussionmentioning

confidence: 98%

“…Alteration of the imbalance in Th1/Th2 differentiation after NO 2 exposure IFN-c is considered to be the product of Th1 cells, and downregulates the Th2 cell differentiation; while, IL-4 is the product of Th2 cells, and down-regulates the Th1 cell differentiation (Heaton et al, 2005;Lama et al, 2011). Therefore, we assessed the IL-4 level and the IFN-c expression in the lungs.…”

Section: Effects Of No 2 Exposure On the Level Of Pro-inflammatory Cymentioning

confidence: 99%

Acute nitrogen dioxide (NO2) exposure enhances airway inflammation via modulating Th1/Th2 differentiation and activating JAK-STAT pathway

Han

Yang

et al. 2015

Chemosphere

View full text Add to dashboard Cite

Increased interleukin-4 and decreased interferon-γ levels in serum of children with asthma

Cited by 38 publications

References 35 publications

Deguelin Attenuates Allergic Airway Inflammation via Inhibition of NF-κb Pathway in Mice

Deguelin Attenuates Allergic Airway Inflammation via Inhibition of NF-κb Pathway in Mice

Total Serum Immunoglobulin E in Children with Asthma

Acute nitrogen dioxide (NO2) exposure enhances airway inflammation via modulating Th1/Th2 differentiation and activating JAK-STAT pathway

Contact Info

Product

Resources

About