Increased Intake of Vegetables, But Not Fruit, Reduces Risk for Hepatocellular Carcinoma: A Meta-analysis

Yang, Yunjun; Zhang, Dan; Feng, Na; Chen, Guo‐Chong; Liu, Jianjiang; Chen, Guiping; Zhu, Yuan

doi:10.1053/j.gastro.2014.08.005

Cited by 107 publications

(78 citation statements)

References 47 publications

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“…Dietary modifications constitute the most important historical component of treat ment regimens in IEMs, and numerous studies over many years have also postulated that dietary effects may contribute to the pathogenesis, prevention and treatment of cancer [96][97][98][99][100] . Specific principles of nutri tion therapy in cancer were outlined in the 1970s with the goals of preventing nutrient deficits, preserving body mass and reducing complications associated with cancer and its treatment 101 .…”

Section: Diagnostic and Therapeutic Implicationsmentioning

confidence: 99%

“…Specific principles of nutri tion therapy in cancer were outlined in the 1970s with the goals of preventing nutrient deficits, preserving body mass and reducing complications associated with cancer and its treatment 101 . More recently, dietary recom mendations tailored to specific forms of cancer or based on prominent aspects of cancer metabolic reprogramming have been proposed [97][98][99][100] . Decades of experience using a vast array of dietary interventions in IEMs might aid our understanding of the potential impact of diet in cancer.…”

Section: Diagnostic and Therapeutic Implicationsmentioning

confidence: 99%

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Metabolic dysregulation in monogenic disorders and cancer — finding method in madness

Erez

DeBerardinis

2015

Nat Rev Cancer

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Cancer is a prime example of a disease process in which carcinogenic and metabolic changes are intertwined to promote cell survival and growth. One approach to unravel this complex relationship is by studying rare, monogenic disorders caused by mutations in genes encoding metabolic enzymes or regulators. There are hundreds of these diseases, most of which manifest in childhood and are collectively termed 'inborn errors of metabolism' (IEMs). Several IEMs demonstrate the consequences of chronic, systemic loss of a particular metabolic activity that can result in malignancy. In this Opinion article, we present a conceptual categorization of IEMs associated with cancer and discuss how assessment of these rare diseases might inform us about the biological foundations of common types of cancer and opportunities for cancer diagnosis and therapy.

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Section: Diagnostic and Therapeutic Implicationsmentioning

confidence: 99%

Section: Diagnostic and Therapeutic Implicationsmentioning

confidence: 99%

Metabolic dysregulation in monogenic disorders and cancer — finding method in madness

Erez

DeBerardinis

2015

Nat Rev Cancer

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“…The aetiology of liver cancer is poorly studied. At present, well-documented unfavorable risk factors for liver cancer included chronic infection with hepatitis B virus (HBV) or C virus (HCV), excessive alcohol intake, and dietary aflatoxin4. The association between liver cancer and other risk factors, including obesity, diabetes mellitus, and smoking, is less clear4.…”

mentioning

confidence: 99%

“…At present, well-documented unfavorable risk factors for liver cancer included chronic infection with hepatitis B virus (HBV) or C virus (HCV), excessive alcohol intake, and dietary aflatoxin4. The association between liver cancer and other risk factors, including obesity, diabetes mellitus, and smoking, is less clear4. Evidence from a recent meta-analysis indicated that increased intake of vegetables, but not fruits, appears to have a protective effect on HCC incidence4.…”

mentioning

confidence: 99%

An updated dose–response meta-analysis of coffee consumption and liver cancer risk

Cao

Chen

et al. 2016

Sci Rep

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Prospective cohort studies of the relationship between coffee consumption and liver cancer risk have drawn different conclusions. Therefore, a dose-response meta-analysis of prospective cohort studies was performed to disentangle this causal relationship. Prospective cohort studies of the association between coffee consumption and liver cancer risk published prior to Jan 9, 2016 were identified by searching in the PubMed and EMBASE databases. Extracted data were analyzed using a random-effects model. Of the 2892 records identified using the search strategy, a total of twenty cohort studies from ten publications were included in the final meta-analysis. The pooled estimate of relative risk (RR) with 95% confidence interval (CI) for highest vs. non/occasional coffee drinkers was 0.55(0.44–0.67). No evidence of publication bias was observed (p for Egger’s test = 0.229). Sensitivity analysis indicated the results were robust. Dose-response analysis revealed a significant linear dose-response relationship between coffee consumption and liver cancer risk (p = 0.36). Subgroup analyses stratified by pre-specified variables (gender, geographic region, and adjusted factors) indicated similar results within individual subgroups. Our meta-analysis suggested that coffee consumption is inversely associated with liver cancer risk.

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“…Using food frequency questionnaires at baseline, it was shown that a vegetable-based dietary pattern is associated with reduced liver cancer risk, while fruit-and meatbased diets did not show any association [24] . This observation was confirmed by a metaanalysis on published studies on the association between vegetable and fruit consumption and the risk of HCC: the risk of HCC decreases by 8% for every 100 g/day increase in vegetable intake [25] . In a large prospective evaluation in a large US cohort addressing the association of two dietary indices, the Healthy Eating Index-2010 (HEI-2010) and the alternate Mediterranean Diet Score (aMED), with HCC incidence and chronic liver disease mortality, it was shown that adherence to dietary recommendations has the potential to reduce the risk of both diseases.…”

Section: Composition Of the Dietmentioning

confidence: 64%

Nutrition and Hepatocellular Cancer

Schütte¹,

Schulz²,

Malfertheiner³

2015

Gastrointest Tumors

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Background: Hepatocellular carcinoma (HCC) significantly contributes to the global burden of cancer. Liver cancer is the third most frequent cause of cancer-related death with HCC representing more than 90% of primary liver cancers. The majority of patients are not only affected by the malignant disease but do also suffer from chronic liver disease. Therefore, several factors impact on the prognosis of patients with HCC, including tumor-related factors, liver function and patient-related factors such as performance status and other comorbidities. The nutritional status is of high significance for the patients' performance status, the tolerance of tumor-targeting therapy and the prognosis of cancer of any type and is specially referenced in HCC. This overview is on current concepts on the role of nutritional factors in hepatocarcinogenesis and the role of nutrition in patients affected by HCC. Summary: Nutritional status and composition of diet are relevant factors related to the risk of HCC. They also have an important role concerning the prognosis of patients with HCC. Besides risk factors, several macro-and micronutrient components have been found to be inversely correlated with the risk of HCC. To prevent disease progression to liver cirrhosis or HCC in patients with nonalcoholic steatohepatitis, it is crucial to optimize the metabolic state. Key Message and Practical Implication: Evidence from well-designed prospective interventional trials with the aim to reduce the HCC incidence or to prolong survival in patients with HCC based on nutritional modification is still to be generated.

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Increased Intake of Vegetables, But Not Fruit, Reduces Risk for Hepatocellular Carcinoma: A Meta-analysis

Cited by 107 publications

References 47 publications

Metabolic dysregulation in monogenic disorders and cancer — finding method in madness

Metabolic dysregulation in monogenic disorders and cancer — finding method in madness

An updated dose–response meta-analysis of coffee consumption and liver cancer risk

Nutrition and Hepatocellular Cancer

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