Increased insulin sensitivity in patients with aldosterone producing adenoma

Ishimori, Masatoshi; Takeda, Noriyuki; Okumura, Syouji; Murai, Toshihiro; Inouye, Hiroshi

doi:10.1111/j.1365-2265.1994.tb02573.x

Cited by 26 publications

(20 citation statements)

References 19 publications

(15 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…21 The impairment of insulin secretion and/or sensitivity have been reported in patients with PA, however the reports concerning this topic are contradictory. Ishimori et al 16 found increased insulin sensitivity in patients with PA. On the other hand our recent study 17 and the study of Shamiss et al 14 demonstrated decreased insulin sensitivity in these patients.…”

Section: Discussionmentioning

confidence: 97%

“…14 Moreover, a series of authors reported alterations of insulin sensitivity and/or release in patients with this disease, although the results of these studies are contradictory. [14][15][16][17] Recently, Torpy et al 18 demonstrated that serum leptin levels in patients with PA increased after surgical removal of aldosteroneproducing adenoma. The reason for this increase was not clarified by Torpy's study.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Serum leptin levels in patients with primary hyperaldosteronism before and after treatment: relationships to insulin sensitivity

et al. 2002

View full text Add to dashboard Cite

Background: Leptin is a protein hormone produced predominantly by adipocytes that plays a role in food intake regulation and a series of other physiological processes including blood pressure regulation. Objectives: The aim of our study was to compare serum leptin levels in patients with primary hyperaldosteronism (PA) with those of healthy subjects and to explore the relationship of serum leptin levels and the parameters of insulin action in these patients before and after surgical or pharmacological treatment. Methods: Serum potassium, leptin, aldosterone, insulin levels and plasma renin activity were measured and hyperinsulinaemic euglycaemic clamp was performed in 11 patients with PA and 11 healthy age-, gender-and body mass index (BMI)-matched subjects. In eight of 11 patients the same measurements were repeated at least 6 months after surgical or pharmacological treatment. Results: The basal serum leptin levels in PA patients did not significantly differ from those of healthy subjects (mean ؎ s.e.m. 8.4 ؎ 1.9 vs 11.2 ؎ 1.8 ng/ml, P ‫؍‬ 0.30), although their insulin sensitivity was significantly impaired (PA patients vs control subjects: glucose dis-

show abstract

Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Serum leptin levels in patients with primary hyperaldosteronism before and after treatment: relationships to insulin sensitivity

et al. 2002

View full text Add to dashboard Cite

show abstract

“…64 This supports the view that essential hypertension is associated with increased insulin resistance and hyperinsulinemia and accounts for enhanced cardiovascular risk in these patients. 65 In contrast, an earlier study even reported increased insulin sensitivity in a small sample of patients with PA. 66 Little is known about interactions between aldosterone and insulin signaling at the molecular level. Low K ϩ has been discussed as a pathogenetic factor for disturbed glucose homeostasis in patients with PA, possibly interfering with insulin receptor function, insulin secretion, or gluconeogenesis.…”

Section: Does Elevated Plasma Aldosterone Negatively Influence Msyn Rmentioning

confidence: 99%

Aldosterone and Metabolic Syndrome

Krug

Ehrhart‐Bornstein

2008

Hypertension

View full text Add to dashboard Cite

“…Clinical features include hypertension, hypokalaemia and metabolic alkalosis. Hyperaldosteronism may alter glucose metabolism through altering insulin secretion, an effect of reduced pancreatic ß-cell intracellular potassium, or altering insulin sensitivity (13,14). Correspondingly, leptin secretion, which is responsive to insulin levels, is reduced in primary aldosteronism and recovers following curative adrenalectomy (15).…”

Section: Dj Torpy Et Almentioning

confidence: 99%

Familial hyperaldosteronism

Torpy

Stratakis

Chrousos³

2000

Braz J Med Biol Res

View full text Add to dashboard Cite

Aldosterone, the major circulating mineralocorticoid, participates in blood volume and serum potassium homeostasis. Primary aldosteronism is a disorder characterised by hypertension and hypokalaemia due to autonomous aldosterone secretion from the adrenocortical zona glomerulosa. Improved screening techniques, particularly application of the plasma aldosterone:plasma renin activity ratio, have led to a suggestion that primary aldosteronism may be more common than previously appreciated among adults with hypertension. Glucocorticoid-remediable aldosteronism (GRA) was the first described familial form of hyperaldosteronism. The disorder is characterised by aldosterone secretory function regulated chronically by ACTH. Hence, aldosterone hypersecretion can be suppressed, on a sustained basis, by exogenous glucocorticoids such as dexamethasone in physiologic range doses. This autosomal dominant disorder has been shown to be caused by a hybrid gene mutation formed by a crossover of genetic material between the ACTH-responsive regulatory portion of the 11ß-hydroxylase (CYP11B1) gene and the coding region of the aldosterone synthase (CYP11B2) gene. Familial hyperaldosteronism type II (FH-II), so named to distinguish the disorder from GRA or familial hyperaldosteronism type I (FH-I), is characterised by autosomal dominant inheritance of autonomous aldosterone hypersecretion which is not suppressible by dexamethasone. Linkage analysis in a single large kindred, and direct mutation screening, has shown that this disorder is unrelated to mutations in the genes for aldosterone synthase or the angiotensin II receptor. The precise genetic cause of FH-II remains to be elucidated.

show abstract

Increased insulin sensitivity in patients with aldosterone producing adenoma

Abstract: Insulin sensitivity was increased in untreated patients with aldosterone producing adenoma. Enhanced insulin receptor binding may contribute to this increased insulin sensitivity.

Cited by 26 publications

References 19 publications

Serum leptin levels in patients with primary hyperaldosteronism before and after treatment: relationships to insulin sensitivity

Serum leptin levels in patients with primary hyperaldosteronism before and after treatment: relationships to insulin sensitivity

Aldosterone and Metabolic Syndrome

Familial hyperaldosteronism

Contact Info

Product

Resources

About