Increased inflammatory markers with altered antioxidant status persist after clinical recovery from severe sepsis: a correlation with low HDL cholesterol and albumin

Vávřová, Lucie; Rychlikova, J.; Mrackova, Magdalena; Nováková, Olga; A, Žák; Novák, František

doi:10.1007/s10238-015-0390-1

Cited by 35 publications

(20 citation statements)

References 64 publications

(62 reference statements)

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“…A study by Sullivan et al found that inflammation, particularly as reflected by IL-6 and CRP levels, appears to be a powerful determinant of albumin [46]. In this connection, systemic inflammation was found not only to reduce albumin synthesis but also to increase its degradation and promote transcapillary leakage [47]. As in the present study, earlier research demonstrated that nutritional status was closely associated with the degree of frailty [48][49][50].…”

Section: Discussionsupporting

confidence: 71%

Evaluation of pro-inflammatory cytokines in frail Tunisian older adults

et al. 2020

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The present study was undertaken to evaluate serum levels of pro-inflammatory cytokines in Tunisian older adults and to examine the relationships between inflammatory marker levels, geriatric, and biochemical parameters. A cross-sectional study was conducted in a population of Tunisian older adults (N = 141, aged 65 and over). Patients were recruited from the Department of Internal Medicine, Fattouma Bourguiba University Hospital (Monastir, Tunisia) and from a nursing home (Sousse, Tunisia). Comprehensive geriatric assessment, history taking and examination including functional and nutritional assessment were done for each participant. Enzyme-linked immunosorbent assay (ELISA) test was used to measure serum cytokine (TNF-α, IL-8, IL-6) levels. The modified Short Emergency Geriatric Assessment score (SEGAm) were used to classify patients as 51 very-frail, 40 frail, and 50 non-frail. The age of the participants (80 men, 61 women) ranged from 65 to 97 years. Serum levels of TNF-α, IL-8 and C-reactive protein (CRP) were significantly higher in very-frail participants compared to frail and non-frail ones. However, no significant differences in IL-6 levels were detected among frailty groups. After adjustment for age, CRP and IL-8 levels remained significantly associated with frailty. Analysis of the receiver operating characteristic (ROC) curve corresponding to IL-8 showed an area under the curve of 0.7 (p = 0.003; 95% CI [0.58–0.81]) and a predictive threshold of 5.27 pg/ml. Positive correlations were found between frailty score, IL-6, and IL-8 levels. In addition, a significant positive correlation was observed between IL-8 levels and Timed Up and Go test results. However, a negative correlation was observed between Mini Nutritional Assessment Short-Form score, IL-6 and CRP levels, as well as between Activities of Daily Living score and serum levels of TNF-α, IL-6, and CRP. In conclusion, the key findings of this study collectively support a role of pro-inflammatory cytokines, TNF-α, CRP, and especially IL-8 in the development of frailty in older adults.

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Section: Discussionsupporting

confidence: 71%

Evaluation of pro-inflammatory cytokines in frail Tunisian older adults

et al. 2020

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“…Another study found, TNF-α, IL-10, and markers of oxidative stress were in negative correlation with HDL cholesterol and albumin. Resolution of the inflammation is probably the primary prerequisite to the normalization of the serum albumin [22]. …”

Section: Discussionmentioning

confidence: 99%

A study on relationship between elderly sarcopenia and inflammatory factors IL-6 and TNF-α

et al. 2017

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BackgroundThis report aims to study the relationship between sarcopenia of elderly in community and inflammatory factors IL-6 and TNF-α.MethodsA total of 441 elders who undertook physical examinations were included into this study. The age of these subjects were >60, in which 235 subjects were male and 206 subjects were female. According to the diagnostic standards of sarcopenia set by EWGSOP and AWGS, these subjects were divided into two groups: sarcopenia, and non-sarcopenia groups. The living habits, disease status, biochemical indexes, and levels of IL-6 and TNF-α of these subjects were investigated.ResultsThe morbidity rate of sarcopenia was 17.02% in male subjects and 18.9% in female subjects. In elderly subjects >80 years old, morbidity rate was 25.3% in male subjects and 35.1% in female subjects. The history of smoking in patients with sarcopenia was long, and their regular exercise history was short (P < 0.01). Furthermore, differences in handgrip strength (HG), fat-free mass (FFM), bone mineral content (BMC), plasma albumin (ALB) and serum creatinine (Cr), and body fat content (FAT) in patients between the sarcopenia and non-sarcopenia groups were statistically significant (P < 0.05). Moreover, differences in IL-6 and TNF-α levels between these two groups were statistically significant (P < 0.05). In addition, BMI was positively correlated to TNF-α levels, and ALB was negatively correlated to IL-6; while BMI and VFA were positively correlated to TNF-α levels, and SMM, HDL-C, Hb, HG were negatively correlated to IL-6 level (P < 0.05). Multiple linear regression analysis suggested plasma ALB and BMI were the independent risk factors of TNF-α, while VFA was the independent risk factor of IL-6.ConclusionsThe onset of sarcopenia was associated with poor exercise habits, disease history, and nutritional status. The emergence of sarcopenia was accompanied by increased levels of inflammation factors TNF-α and IL-6. Plasma albumin, BMI, and VFA were inflammatory factor predictors of TNF and IL-6.

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“…Patients with hypoalbuminemia show severe deficits in cellular immunity. The correlation between marked oxidative stress and low levels of serum albumin is supported by some clinical studies [94]. The potent antioxidant capacity of albumin administration can explain its beneficial effect.…”

Section: Hypoalbuminemia In Critically Ill Patientsmentioning

confidence: 89%

Non-oncotic properties of albumin. A multidisciplinary vision about the implications for critically ill patients

Ferrer

Mateu

Maseda

et al. 2017

Expert Review of Clinical Pharmacology

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Effective resuscitation with human albumin solutions is achieved with less fluid than with crystalloid solutions. However, the role of albumin in today's critical care unit is also linked to its multiple pharmacological effects. Areas covered: The potential clinical benefits of albumin in select populations of critically ill patients like sepsis seem related to immunomodulatory and anti-inflammatory effects, antibiotic transportation and endothelial stabilization. Albumin transports many drugs used in critically ill patients. Such binding to albumin is frequently lessened in critically ill patients with hypoalbuminemia. These changes could result in sub-optimal treatment. Albumin has immunomodulatory capacity by binding several bacterial products. Albumin also influences vascular integrity, contributing to the maintenance of the normal capillary permeability. Moreover, the albumin molecule encompasses several antioxidant properties, thereby significantly reducing re-oxygenation injury, which is especially important in sepsis. In fact, most studies of albumin administration are a combination of a degree of resuscitation with a degree of maintenance or supplementation of albumin. Expert commentary: The potential clinical benefits of the use of albumin in selected critically ill patients such as sepsis seem related to its immunomodulatory and anti-inflammatory effects, antioxidant properties, antibiotic transportation and endothelial stabilization. Additional studies are warranted to further elucidate the underlying physiologic and molecular rationale.

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Increased inflammatory markers with altered antioxidant status persist after clinical recovery from severe sepsis: a correlation with low HDL cholesterol and albumin

Cited by 35 publications

References 64 publications

Evaluation of pro-inflammatory cytokines in frail Tunisian older adults

Evaluation of pro-inflammatory cytokines in frail Tunisian older adults

A study on relationship between elderly sarcopenia and inflammatory factors IL-6 and TNF-α

Non-oncotic properties of albumin. A multidisciplinary vision about the implications for critically ill patients

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