Increased Indoleamine 2, 3-Dioxygenase expression modulates Th1/Th17/Th22 and Treg pathway in humans with Helicobacter Pylori-Infected gastric mucosa

Azadegan-Dehkordi, Fateme; Shirzad, Hedayatollah; Ahmadi, Reza; Bashash, Davood; Abdollahpour‐Alitappeh, Meghdad; Luzza, Francesco; Larussa, Tiziana; Nahid‐Samiei, Mahboobeh; Rahimian, Ghorbanali; Shafigh, Mohammadhadi; Bagheri, Nader

doi:10.1016/j.humimm.2020.10.005

Cited by 15 publications

(9 citation statements)

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“…Helicobacter pylori is a gram-negative, microaerophilic, and spiral bacterium identified in 1982 (Marshall Warren 1984 ). Helicobacter pylori is recognized as the cause of gastritis, gastrointestinal ulcers and gastric carcinoma (gastric, intestinal ulcers), MALT lymphoma, and non-gastric diseases associated with Helicobacter pylori (Azadegan-Dehkordi et al 2020 ; Fujikawa et al 2003 ; Khaledi et al 2020 ; Lee et al 2005 ; Sanaii et al 2019 ). The outcome of infection with this bacterium depends on several factors such as bacterial isolates, host inflammatory responses, host genetic diversity, and environmental factors (Montecucco de Bernard 2003 ; Nahid-Samiei et al 2020 ; Rhead et al 2007 ; Sanaei et al 2020 ).…”

Section: Introductionmentioning

confidence: 99%

Correlation between clarithromycin resistance, virulence factors and clinical characteristics of the disease in Helicobacter pylori infected patients in Shahrekord, Southwest Iran

et al. 2021

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The purpose of this study was to determine the mutations associated with clarithromycin resistance in Helicobacter pylori strains isolated from biopsy samples that were collected from the endoscopic ward of Shahrekord Hajar teaching Hospital and also to study the frequency of virulence factor and their correlation and pathological findings with clarithromycin resistance during the years 2019–2020. In this cross-sectional descriptive study, 152 patients with Helicobacter pylori infection were considered, and then, two common A2142G and A2143G mutations in the 23SrRNA gene associated with resistance were analyzed by Real-time PCR (Taq man). The presence of vacA, iceA1, iceA2, cagA, babA2, and oipA virulence genes was investigated by PCR and electrophoresis in 8% polyacrylamide gel. Then, data were analyzed using the relevant statistical tests. In this study, the frequency of Helicobacter pylori was 76% and the frequency of mutant isolates was 57.2%. The frequencies of A2142G and A2143G point mutations were 42.1% and 28.3%. There was a significant correlation among oipA, vacA, and iceA1 virulence factors, type of disease, chronic inflammatory score, and glandular atrophy with the antibiotic resistance to clarithromycin. There was no significant correlation between the age and sex of the patients with antibiotic resistance. According to the results of this study, it seems that the use of clarithromycin to combat this bacterium should be limited.

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Section: Introductionmentioning

confidence: 99%

Correlation between clarithromycin resistance, virulence factors and clinical characteristics of the disease in Helicobacter pylori infected patients in Shahrekord, Southwest Iran

et al. 2021

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“…Several pieces of evidence demonstrated that inhibiting IDO will reduce Kyn/AhR-mediated T reg differentiation, providing an effective strategy for the prevention and treatment of inflammation-related colon cancer, and has reference value for the treatment of GC [ 79 ]. IDO plays an important role in immunosuppressive pathways, and increased expression of IDO proteins can alter the number of Th1, Th17, Th22 and T reg cells, which may lead to an increased risk of peptic ulcer development in patients infected with H. pylori, thereby increases the likelihood of GC [ 80 ]. Compared with other participating enzymes, indoleamine-2,3-dioxygenase 1 (IDO1) plays a decisive role in the decomposition of tryptophan into kynurenine [ 75 , 81 , 82 ].…”

Section: Metabolic Changes In the Microenvironment Of Gcmentioning

confidence: 99%

Impacts and mechanisms of metabolic reprogramming of tumor microenvironment for immunotherapy in gastric cancer

et al. 2022

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Metabolic disorders and abnormal immune function changes occur in tumor tissues and cells to varying degrees. There is increasing evidence that reprogrammed energy metabolism contributes to the development of tumor suppressive immune microenvironment and influences the course of gastric cancer (GC). Current studies have found that tumor microenvironment (TME) also has important clinicopathological significance in predicting prognosis and therapeutic efficacy. Novel approaches targeting TME therapy, such as immune checkpoint blockade (ICB), metabolic inhibitors and key enzymes of immune metabolism, have been involved in the treatment of GC. However, the interaction between GC cells metabolism and immune metabolism and how to make better use of these immunotherapy methods in the complex TME in GC are still being explored. Here, we discuss how metabolic reprogramming of GC cells and immune cells involved in GC immune responses modulate anti-tumor immune responses, as well as the effects of gastrointestinal flora in TME and GC. It is also proposed how to enhance anti-tumor immune response by understanding the targeted metabolism of these metabolic reprogramming to provide direction for the treatment and prognosis of GC.

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“…Helicobacter pylori ( H. pylori ) infection is a major bacterial infection worldwide, leading to various gastroduodenal diseases, including chronic gastritis, peptic ulcer disease (PUD), gastric cancer (GC) and MALT (mucosa-associated lymphoid tissue) lymphoma [ 1 , 2 , 3 , 4 ]. However, most infected patients with H. pylori remain asymptomatic, and increased disease risk is related to the genetic diversity of H. pylori strains or inflammatory responses governed by host genetic diversity, or both [ 5 , 6 , 7 ]. In the hostile acidic environment of the stomach, virulence factors play essential roles in the colonization and survival of H. pylori .…”

Section: Introductionmentioning

confidence: 99%

Frequency of virulence-associated genotypes of Helicobacter pylori and their correlation with clinical outcome and histological parameters in infected patients

Abadi

Ashrafi-Dehkordi

Ahmadi

et al. 2021

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Helicobacter pylori ( H. pylori ) is a gram-negative which can cause several gastroduodenal diseases, including gastritis and peptic ulcer disease (PUD). H. pylori specific genotypes have been related to increased occurrence of gastritis and PUD. The aim of this study was to investigate the clinical relevance of the major virulence factors of H . pylori with clinical outcomes and histological parameters in Iranian patients. Totally, 200 subjects with PUD and gastritis disease who underwent gastroduodenal endoscopy were enrolled in this study. The presence of the cagA , vacA , oipA , babA2 , and iceA genes in antral gastric biopsy specimens were determined by polymerase chain reaction (PCR) and the results were compared with clinical outcomes and histological parameters. The frequency of babA2 + , oipA + , vacA s1/m2 , and vacA m2 genes was significantly higher in patients with peptic ulcer disease compared with patients with gastritis. In contrast, the frequency of vacA s1/m1 gene was significantly higher in gastritis subjects than PUD subjects. The high-density scores of H. pylori were strongly associated with iceA1 ¯ , babA2 + , and oipA + genes. Additionally, the high polymorphonuclear cell infiltration and high mononuclear cell infiltration scores were strongly associated with the cagA + , iceA1 ¯ , oipA + genes and cagA + , babA2 + , oipA + genes, respectively. Our study indicated that the vacA , babA2 , and oipA virulence factors are related to a higher risk of PUD in subjects with H. pylori -infection. Infection with these strains was associated with a more severe gastropathy.

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Increased Indoleamine 2, 3-Dioxygenase expression modulates Th1/Th17/Th22 and Treg pathway in humans with Helicobacter Pylori-Infected gastric mucosa

Cited by 15 publications

References 28 publications

Correlation between clarithromycin resistance, virulence factors and clinical characteristics of the disease in Helicobacter pylori infected patients in Shahrekord, Southwest Iran

Correlation between clarithromycin resistance, virulence factors and clinical characteristics of the disease in Helicobacter pylori infected patients in Shahrekord, Southwest Iran

Impacts and mechanisms of metabolic reprogramming of tumor microenvironment for immunotherapy in gastric cancer

Frequency of virulence-associated genotypes of Helicobacter pylori and their correlation with clinical outcome and histological parameters in infected patients

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