Increased Incidental Thyroid Cancer in Patients With Subclinical Chronic Lymphocytic Thyroiditis

On the basis of Hashimoto's thyroiditis, to form papillary thyroid carcinoma, metastasized and then to de-differentiate into poorly differentiated squamous cell carcinoma

“…Giuseppa G et al found that in a study of 305 cases of PTC divided into two groups, up to 40.2% of the patients coexisted both diffuse HT and PTC in one group, and the results of this study indicated that the coexistence of HT and PTC was very high (4). Several other studies have also shown that HT is closely related to PTC (2,5,21,22). Studies also suggested that HT might be an independent risk factor for thyroid cancer (23).…”

“…HT is the most common thyroid immune diseases. There is overwhelming evidence to show that HT is closely related to thyroid cancer, especially PCT (2)(3)(4)(5)(6)(7)(21)(22)(23). Giuseppa G et al found that in a study of 305 cases of PTC divided into two groups, up to 40.2% of the patients coexisted both diffuse HT and PTC in one group, and the results of this study indicated that the coexistence of HT and PTC was very high (4).…”

“…Up to 40% of PTC is accompanied by HT and/or CLT. On the basis of immune in ammation, thyroid cancer, especially PTC could be induced (3)(4)(5)(6). However, the association between thyroid cancer and concomitant autoimmune thyroiditis is controversial (4,7).…”

Diagnostic value of modified systemic inflammation score for prediction of malignancy in patients with indeterminate thyroid nodules

“…Inflammation is thought to be a crucial role in TC. 4,5,8 However, it seems that the majority of the researchers investigating serum biomarkers and thyroid carcinogenesis focus on the progression and treatment response, and a few of them focus on the diagnosis and the risk of developing TC. 6,7 In the present study, which we designed to predict malignancy in patients with ID TNs, TT was performed in 97.5% of the cases.…”

“…4 Lymphocytic thyroiditis and TC coexistence and how immune mechanisms work in the process of malignant transformation have also been reported many times in the literature. 4,5 Through these bases, several studies have been conducted focusing on whether cancer diagnosis and prognosis can be predicted by measuring some leukocyte fractions or acute phase reactants in the blood. 6e8 Especially increased serum C-reactive protein (CRP) and low serum albumin (ALB) levels are accepted as indicators of systemic inflammation and are also components of the modified Glasgow Prognostic Score, which is a clinically inflammation-based scoring system and can predict the prognosis of colorectal cancers.…”