Increased Incidence of Second Primary Melanoma in Patients With a Previous Cutaneous Melanoma

Abstract

Patients with cutaneous melanoma are at very high risk for development of second primary melanoma. This risk approximates 0.5% per year for the first 5 years of follow-up. Patients aged 15-39 and patients aged 65-79 have a particularly high incidence of second melanoma, suggesting different causes for the development of second primaries. All patients with melanoma should undergo careful surveillance for second melanomas in addition to routine screening for recurrence.

Various dermatoses what the patients with cutaneous melanoma had anxiety for the recurrence during postoperative surveillance

“…The incidence of local recurrence was 3.1%; this was consistent with previous studies that reported a local recurrence rate of approximately 3%∼5% [13][14][15] . The prevalence of a second primary melanoma following a primary CM was 0.6%; this was similar than the prevalence of 0.5%∼5.5% reported by previous studies [16][17][18][19] . We also observed a lower prevalence (1.3%) of nonmelanoma skin cancer (NMSC) compared with a previous study (10.7%) 20 .…”

Malignant Melanoma S3‐Guideline “Diagnosis, Therapy and Follow‐up of Melanoma”

“…This course of action should at least be adopted in high-risk patients (e.g. dysplastic nevus syndrome, familial melanoma) [618].…”

Single versus multiple primary melanomas

“…1,2 Various single-center and population-based studies have reported that between 1.2% and 8.6% of patients who have a history of melanoma will develop subsequent melanomas. [3][4][5][6][7][8][9][10][11][12] Several risk factors for the development of more than 1 primary melanoma have been established, the most important of which include a family history of melanoma and a personal history of dysplastic nevi. 10,[12][13][14] The initial melanoma in patients who have multiple primary melanomas (MPM) usually is the thickest of the melanomas that eventually develop.…”