Increased incidence of renal and urinary tract anomalies among individuals with fetal alcohol spectrum disorders (FASD)

Abstract

BackgroundFetal alcohol spectrum disorders (FASD) in a spectrum of neurodevelopmental conditions resulting from prenatal alcohol exposure (PAE). Animal models have confirmed the toxic effects of PAE on the kidneys and urinary tract, yet the evidence from human studies is contradictory. The purpose of this study was to establish the incidence of renal and urinary tract anomalies (RUTA), impaired kidney function, and hypertension among patients with FASD.MethodsChildren from the FASD Diagnostic Center with FASD diagnosis (FAS, pFAS, or ARND) were offered participation in the study. The control group consisted of patients from the Gastroenterology Department of the same hospital. The patients underwent renal and urinary tract ultrasound examination. The serum creatinine level was also evaluated and the blood pressure was taken twice. Polish OLAF charts were used to determine the percentiles of blood pressure.ResultsThe incidence of kidney and urinary tract defects in the study group was significantly higher than in the control group (OR: 2.64 [1.60–4.34]). The kidney size among FASD patients was significantly lower (73 mm [60–83] vs. 83 mm [70–96]; p < .001) when compared to the control group. No differences were observed in the estimated glomerular filtration rate. In the study group, significantly lower systolic blood, diastolic blood pressure, percentile of systolic pressure, and diastolic pressure were observed.ConclusionsRUTA occurred more frequently among patients with FASD compared to the control group, and decreased kidney size was also demonstrated among patients with FASD. However, impaired kidney function and the risk of hypertension were not observed.

The Impact of Prenatal Alcohol Exposure on the Autonomic Nervous System and Cardiovascular System in Rats in a Sex-Specific Manner

“…Furthermore, the increase in creatinine levels can be attributed to the multifactorial effects of prenatal ethanol consumption. A correlation between PAE and several renal complications, including ureteral obstruction, renal hypoplasia, and hydronephrosis, as well as its effects on vascular function, leading to artery stiffness through the alteration of endothelial and smooth muscle function were reported [ 17 , 43 , 44 ]. Prior research also demonstrated a nephron deficit with increased apoptosis and an elevation in blood pressure [ 43 , 45 ].…”