Increased incidence of mosaic embryos with the microinjection of spermatozoa with abnormal morphology

Delgado, A.; Santos, M. de los; Buendía, Pilar; Simón, Carlos; Remohı́, José; Pellicer, A.

doi:10.1016/j.fertnstert.2007.07.785

Cited by 2 publications

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“…Our findings appear to be well substantiated by Magli et al, 2009, 60 Simon et al, 2007 62 and Silber et al, 2003 51 who reported that post-meiotic abnormalities as mosaicism in early developmental stages are proportional to the severity of the male factor condition and that mosaicism rates increase as the degree of sperm characteristics decreased. However, higher rates were reported by Simon et al, 2007 who detected mosaicism in 15.1% and 20.8% of embryos of men with moderate and severe teratozoospermia, respectively.…”

Section: Discussionsupporting

confidence: 88%

The Effect of Teratozoospermia on Sex Chromosomes in Human Embryos

Nayel¹,

Mahrous²,

Khalifa³

et al. 2021

TACG

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Purpose The aim of this study is to evaluate the effect of abnormal semen morphology on the frequency of sex chromosomal abnormalities in embryos obtained by ICSI, which represents the first to be studied in Egyptian population. Methods Forty-two couples suffering from male infertility due to teratozoospermia were divided into two groups: patients with severe and moderate teratozoospermia (group A and B, respectively). All involved couples were subjected to careful history taking and had a normal clinical examination and karyotype. Females were subjected to hormonal assays, pelvic ultrasound, hysterosalpingography and yielded normal results, while male partners were subjected to computerized semen analysis. Preimplantation genetic diagnosis was performed for all suitably developed embryos including embryo biopsy, fixation of biopsied cells and fluorescent in situ hybridization (FISH) analysis. Results Couples included in the two groups were found to be homogenous in terms of age of both partners and duration of infertility. Interpretation of FISH results was performed by evaluation of embryos’ chromosomal constitution as regards abnormalities in chromosomes X, Y and 18. Twenty-seven embryos (48.2%) were found chromosomally abnormal in group A, while only 14 embryos (25.0%) were found chromosomally abnormal in group B. Aneuploidies involved only sex chromosomes were tripled in group A embryos when compared to their frequency in group B embryos (26.8% and 8.3%, respectively) with statistically significant difference between the two groups (p=0.002). Monosomies were the most common type of aneuploidy and were significantly higher in group A (14.3%) when compared to group B (3.6%) (p=0.047). Embryos with mosaic abnormalities were more common in group A (12.5%) when compared to group B (3.6%), however not statistically significantly different (p= 0.162). A significant difference between the two studied groups as regards the total number of potentially viable chromosomal abnormalities detected and the potentially viable sex chromosomal aneuploidies detected (p<0.001 and p=0.002), respectively. Conclusion The cases with severe teratozoospermia undergoing ICSI treatment can display a higher rate of sex chromosome aneuploidies in their embryos (threefold) than cases with moderate teratozoospermia.

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Section: Discussionsupporting

confidence: 88%

The Effect of Teratozoospermia on Sex Chromosomes in Human Embryos

Nayel¹,

Mahrous²,

Khalifa³

et al. 2021

TACG

View full text Add to dashboard Cite

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“…La evaluación morfológica por el embriólogo/a es una metodología no invasiva para el embrión a transferir pero que no está libre de sus desventajas: es altamente subjetivo, requiere gran experiencia y está restringido a momentos puntuales de observación dentro de la rutina del laboratorio, lo cual supone una pérdida de información del desarrollo global del embrión (1) (2). Los principales parámetros a tener en cuenta en la evaluación morfológica del embrión previo al estadio de blastocisto son: número y simetría de las células, grado y tipo de fragmentación, y multinucleación (3)(4).…”

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Morphological aspects in embryonic development: Fragmentation and its relationship with embryonic quality. Bibliographic review

Ferrón¹,

Bonet²

2017

Actual. Med

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Aspectos morfológicos en el desarrollo embrionario: Fragmentación y su relación con la calidad embrionaria. Revisión bibliográfica ResumenEl objetivo de este estudio es hacer una revisión de la fragmentación celular y correlacionarla con la calidad embrionaria. Para ello se realizó una búsqueda sistemática de la literatura sobre «fragmentación embrionaria» y «calidad embrionaria». Para este estudio se incluyeron estudios de parámetros morfológicos por observación convencional asi como los estudios de morfocinética mediante tecnología time-lapse. En primer lugar, se realizó una búsqueda en Cochrane, MEDLINE, MEDES, ENFISPO y EMBASE de todo tipo de artículos (todas las publicaciones hasta diciembre de 2016). Trabajos sobre fragmentación embrionaria, parámetros morfológicos embrionarios y calidad embrionaria, tasa de fragmentación, tasa de implantación y fragmentación embrionaria, morfocinética embrionaria e implantación embrionaria. Se revisaron los resúmenes y se identificaron artículos potencialmente relevantes. De los 50 artículos revisados, 10(20%) fueron ensayos aleatorizados controlados, 21(42%) estudios epidemiológicos observacionales, 8(16%) estudios experimentales, 11(22%) recomendaciones internacionales. Fueron descartados 20(40%) estudios por no ser randomizados y 21(42%) por tratarse de estudios de investigación básica, trabajos de revisión o estudios observacionales. Finalmente se seleccionaron 10(20%) artículos para la revisión por tener relación directa con el objetivo de la revisión. La revisión de los artículos seleccionados relaciona el parámetro de fragmentación embrionaria con otros parámetros morfoló-gicos, no considerándolo como único indicador de una buena calidad embrionaria, valorando el conjunto de los parámetros morfológicos considerado. AbstractThe aim of the present study is to review cell fragmentation and to correlate it with embryonic quality. For that, a systematic search of the literature on "embryonic fragmentation" and "embryonic quality" was carried out. For this study, we included morphological parameters researches by conventional observation as well as morphokinetic researches using time-lapse system. First, we searched for all types of articles (all publications until December 2016) in Cochrane, MEDLINE, MEDES, ENFISPO and EMBASE. Moreover, we researched for works on embryonic fragmentation, embryonic morphological parameters and embryonic quality, fragmentation rate, implantation rate and embryonic fragmentation, embryonic morphokinetic and embryonic implantation. Abstracts were reviewed and it was identified potentially relevant articles. Of the 50 articles reviewed, 10 (20%) were randomized controlled trials, 21 (42%) observational epidemiological studies, 8 (16%) experimental studies, 11 (22%) international recommendations; 20 (40%) studies were discarded because they were not randomized and, also, 21 (42%) because they were basic research studies, revision studies or observational studies. Finally, 10 (20%) articles were selected for review because they were directly r...

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Increased incidence of mosaic embryos with the microinjection of spermatozoa with abnormal morphology

Cited by 2 publications

References 0 publications

The Effect of Teratozoospermia on Sex Chromosomes in Human Embryos

The Effect of Teratozoospermia on Sex Chromosomes in Human Embryos

Morphological aspects in embryonic development: Fragmentation and its relationship with embryonic quality. Bibliographic review

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