Increased Incidence of Itching and Herpes Simplex in Patients Given Epidural Morphine After Cesarean Section

Gieraerts, Roland; Navalgund, A.; Vaes, L.; Soetens, M.; Chang, J. S.; Jahr, Jonathan S.

doi:10.1213/00000539-198712000-00023

Cited by 44 publications

(4 citation statements)

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“…112,113 Reactivation of the herpes virus typically occurs two to five days after epidural administration of opioid, re,H4 Manifestation of symptoms characteristically occurs in the same sensory innervation area as the primary infection, which is usually facial areas innervated by the trigeminal nerve. "3 A similar link between the use of intrathecal opioids in young patients and reactivation of the herpes virus has been suggested.…”

Section: Herpes Simplex Labialis Virus Reactivationmentioning

confidence: 99%

Side effects of intrathecal and epidural opioids

1995

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Section: Herpes Simplex Labialis Virus Reactivationmentioning

confidence: 99%

Side effects of intrathecal and epidural opioids

1995

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“…Similarly, Gieraerts et al . 28 reported a high prevalence of HSV infection in patients receiving epidural morphine following cesarean section. In the same way, a significant association between the use of epidural morphine, which is commonly used for postoperative analgesia after cesarean section, and the reactivation of oral herpes in the obstetric population has also been reported 29 .…”

Section: Discussionmentioning

confidence: 99%

Herpes simplex encephalitis in a patient abusing morphine: a case report from Nepal

Bhattarai²,

Shah

et al. 2023

Annals of Medicine &Amp; Surgery

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Introduction: Herpes simplex encephalitis results from either primary infection with the herpes simplex virus (HSV) or reactivation of latent HSV residing within the nuclei of sensory neurons. Opioid’s administration is known to reactivate HSV infection. Case presentation: We report a 46-year-old male who was in a rehabilitation center for 17 days for abusing morphine for 2 years. Discussion: Chronic morphine use weakens immune system thereby, making body prone for development of infection. Opioids may reactivate HSV infection because of their immunosuppressive function. Conclusion: Herpes simplex encephalitis is a potentially fatal condition but can be treated with early diagnosis and intervention.

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“…~8 One additional adverse effect in adults reported with epidural morphine, but not with fentanyl, is reactivation of herpes simplex infections. 19,20 With such information, it appears that the administration of epidural fentanyl at the thoracic level is advantageous over either the administration of larger doses at the lumbar level or the use of epidural morphine. Another means of achieving catheter placement without direct insertion at the thoracic level is to thread the catheter from the caudal level.…”

Section: Discussionmentioning

confidence: 99%

Thoracic epidural anaesthesia in infants and children

Tobias

Löwe²,

O'Dell³

et al. 1993

Can J Anaesth

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Accepted for publication 20th April, 1993. In children, postoperative analgesia is generally provided by either parenteral narcotics or regional anaesthetic techniques such as epidural anaesthesia. Although the efficacy of epidural anaesthesia in providing postoperative analgesia in children has been demonstrated, i-3 these studies have utilized either caudal or lumbar placement of the epidural catheter. The majority of experience with thoracic epidural analgesia in children has involved catheter placement from the caudal approach. 4-6Our review of the literature has found only three previous reports concerning the use of epidural catheters placed at the thoracic level for postoperative analgesia in children. 1,7,8 The earliest of these studies by Meigner et al. 7 demonstrated the safety and efficacy of this technique in eight children. The second study s included 30 CAN J ANAESTH 1993 / 40:9 / pp 879-82

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Increased Incidence of Itching and Herpes Simplex in Patients Given Epidural Morphine After Cesarean Section

Cited by 44 publications

References 0 publications

Side effects of intrathecal and epidural opioids

Side effects of intrathecal and epidural opioids

Herpes simplex encephalitis in a patient abusing morphine: a case report from Nepal

Thoracic epidural anaesthesia in infants and children

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