Increased incidence of germ cell testicular cancer in New Zealand Maoris

Wilkinson, Tim; Colls, B. M.; Schluter, Philip J.

doi:10.1038/bjc.1992.162

Cited by 41 publications

(16 citation statements)

References 10 publications

(10 reference statements)

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“…8 The only nonwhite population with a relatively high incidence of TGCT is the Maoris of New Zealand. 9 Interestingly, the incidence of TGCT in many countries has increased significantly during the last century. 8,[10][11][12] Based on SEER data, McGlynn and collaborators reported an overall rise of 44% in the incidence in the United States from 1973 to 1998, from 3.35 per 100 000 men to 4.84 per 100 000.…”

Section: Incidencementioning

confidence: 99%

Origins and molecular biology of testicular germ cell tumors

2005

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Section: Incidencementioning

confidence: 99%

Origins and molecular biology of testicular germ cell tumors

2005

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“…87 In Denmark, a significant increase in the incidence of testicular cancer was found among adolescent boys, whereas no increase occurred among children up to 4 years of age. 88 Maoris, who have the highest incidence of testicular cancer among the nonwhite populations, 89 start puberty late compared with the white population in New Zealand. 90 This contradiction suggests that other factors, such as intrauterine growth restriction and a possible unfavorable hormonal milieu, may contribute to the cancer incidence among Maoris.…”

Section: Testicular and Prostate Cancermentioning

confidence: 99%

Public Health Implications of Altered Puberty Timing

et al. 2008

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Changes in puberty timing have implications for the treatment of individual children, for the risk of later adult disease, and for chemical testing and risk assessment for the population. Children with early puberty are at a risk for accelerated skeletal maturation and short adult height, early sexual debut, potential sexual abuse, and psychosocial difficulties. Altered puberty timing is also of concern for the development of reproductive tract cancers later in life. For example, an early age of menarche is a risk factor for breast cancer. A low age at male puberty is associated with an increased risk for testicular cancer according to several, but not all, epidemiologic studies. Girls and, possibly, boys who exhibit premature adrenarche are at a higher risk for developing features of metabolic syndrome, including obesity, type 2 diabetes, and cardiovascular disease later in adulthood. Altered timing of puberty also has implications for behavioral disorders. For example, an early maturation is associated with a greater incidence of conduct and behavior disorders during adolescence. Finally, altered puberty timing is considered an adverse effect in reproductive toxicity risk assessment for chemicals. Recent US legislation has mandated improved chemical testing approaches for protecting children's health and screening for endocrinedisrupting agents, which has led to changes in the US Environmental Protection Agency's risk assessment and toxicity testing guidelines to include puberty-related assessments and to the validation of pubertal male and female rat assays for endocrine screening.

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“…However, it is the most common cancer in young and middle-aged males. Furthermore, there have been reports indicating that testis cancer is increasing in many parts of the world (Adami et al, 1994;Forman and Moller, 1994;Moller, 1993;Wilkinson et al, 1992;Pearce et al, 1987;Boyle et al, 1987;Brown et al, 1986a). A recent European study estimated that the age-standardized incidence rate of testis cancer doubles every 15 to 25 years in Northern European countries (Adami et al, 1994).…”

mentioning

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Continuing increase in incidence of germ-cell testis cancer in young adults: Experience from Connecticut, USA, 1935–1992

Zheng

Holford

et al. 1996

Int. J. Cancer

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and 4Connecticut Tumor Registiy, Hartford, CT, USA.The current study is designed to examine long-term trends by histologic types of testis cancer in Connecticut. A regression model was used to identify age, period, or cohort as determinants of the time-trend on histologic types of testis cancer. The results from this descriptive epidemiologic study show that the overall age-adjusted incidence rate of testis cancer has increased 3.5-fold in Connecticut during the past nearly 60 years of cancer registration. The rates for seminoma and nonseminoma have been increasing since the mid-1950s and increase in a similar manner for those aged I5 to 49. The largest increase was observed in the age groups 20 to 44 for seminoma and 15 to 34 for non-seminoma. The observed increase was limited to whites. The results from age-period-cohort modeling suggest that the observed increase in seminoma before 1950s could be largely attributable to a period effect, while the increase for cohorts born after about I 9 I0 both for seminoma and for non-seminoma are mainly explained by a strong birthcohort effect. Therefore, the observed increase in germ-cell testis cancer in this population is likely to continue in the coming years. Thus far, the proposed hypotheses, such as exposure to DES in utero, earlier lifetime exposures to viruses, trauma or unusual amounts of heat to the testis, cannot adequately explain the observed incidence patterns of testis cancer. Analytical epidemiologic studies with large sample size are urgently needed to examine the risk factors responsible for the increase.Q 1996 Wiley-Liss, Inc.

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Increased incidence of germ cell testicular cancer in New Zealand Maoris

Cited by 41 publications

References 10 publications

Origins and molecular biology of testicular germ cell tumors

Origins and molecular biology of testicular germ cell tumors

Public Health Implications of Altered Puberty Timing

Continuing increase in incidence of germ-cell testis cancer in young adults: Experience from Connecticut, USA, 1935–1992

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