Increased incidence of diabetes mellitus in the patients with transitional cell carcinoma of urinary bladder

Kravchick, Sergey; Gal, Rivka; Cytron, Shmuel; Peled, Ronit; Weissman, Yona; Mukamel, E.; Koren, Rumelia

doi:10.1007/bf03032606

Cited by 27 publications

(26 citation statements)

References 17 publications

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“…We identified eight case-control studies [12][13][14][15][16][17][18][19], three cohort studies [20][21][22] and seven cohort studies of hospitalised diabetic patients using external population comparisons [23][24][25][26][27][28][29]. One case-control study [12] was excluded because no measure of the RR was reported and the RR could not be calculated.…”

Section: Search Resultsmentioning

confidence: 99%

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Diabetes mellitus and risk of bladder cancer: a meta-analysis

et al. 2006

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Aims/hypothesis Epidemiological evidence indicates that individuals with diabetes mellitus have an increased risk of several cancers. We performed a systematic review with meta-analysis to evaluate the association between diabetes and risk of bladder cancer. Methods Pertinent studies were identified by searching MEDLINE (from January 1966 to July 2006) and by reviewing the reference lists of retrieved articles. We included case-control and cohort studies reporting relative risk (RR) estimates with 95% CIs (or data to calculate them) of bladder cancer associated with diabetes. Studies of type 1 diabetes were not included. Summary RRs were calculated using a random-effects model. Results A total of 16 studies (seven case-control studies, three cohort studies and six cohort studies of diabetic patients) fulfilled the inclusion criteria. Analysis of all studies showed that diabetes was associated with an increased risk of bladder cancer, compared with no diabetes (RR=1.24, 95% CI 1.08-1.42). There was strong evidence of heterogeneity among these studies (p<0.0001). Stratification by study design found that diabetes was associated with an increased risk of bladder cancer in case-control studies (RR=1.37, 95% CI 1.04-1.80, p heterogeneity =0.005) and cohort studies (RR=1.43, 95% CI 1.18-1.74, p heterogeneity =0.17), but not in cohort studies of diabetic patients (RR=1.01, 95% CI 0.91-1.12, p heterogeneity =0.35). Conclusions/interpretation Findings from this meta-analysis suggest that individuals with diabetes may have a modestly increased risk of bladder cancer.

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Section: Search Resultsmentioning

confidence: 99%

“…Studies in animals support a potential role of IGF-I in bladder tumorigenesis [42]. Diabetes is also associated with an increased risk of urinary tract infection [43], which has been related to bladder cancer risk [17].…”

Section: Discussionmentioning

confidence: 99%

Diabetes mellitus and risk of bladder cancer: a meta-analysis

et al. 2006

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“…However, the epidemiological relationship between these two important diseases has not been studied until now. Recently, there are noteworthy epidemiological studies concerning the association between diabetes and transitional cell carcinoma of the bladder (17)(18)(19)(20).…”

Section: Diabetes Screening Of Oral Cancer Patientsmentioning

confidence: 99%

Diabetes and Oral Tumors in Hungary

et al. 2004

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OBJECTIVE -Numerous publications have already demonstrated that diabetes is a risk factor for the development of periodontal diseases and various inflammatory lesions in the oral mucosa. A possible correlation between diabetes and oral premalignancies and tumors was examined in this study, as no literature data are available concerning this problem.RESEARCH DESIGN AND METHODS -Stomato-oncological screening was carried out on 200 diabetic patients in the medical departments; the control group included 280 adult dentistry outpatients. The lesions found were classified into three groups: inflammatory lesions, benign tumors, and precancerous lesions. A retrospective diabetes screening of 610 inpatients with histologically confirmed oral malignancies was also performed. The control group comprised 574 complaint-and tumor-free adults. Fasting blood glucose levels were determined in both groups, and the tumor location was registered in the cancer patients.RESULTS -Benign tumors were found in 14.5% and precancerous lesions in 8% of diabetic patients. In the control group these values were significantly lower, at 6.4 and 3.2%, respectively (P Ͼ 0.01). Earlier Hungarian screening studies indicated similar frequency of these lesions in the general population. The proportion of oral cavity lesions was higher among diabetic patients compared with that of the control patients. In the oral cancer patient group, diabetes was present in 14.6% and an elevated blood glucose level in 9.7%. These values are significantly higher than those for the tumor-free control group (P Ͻ 0.01). The gingival and labial tumor location was significantly more frequent among diabetic cancer patients than in the nondiabetic group (P Ͻ 0.01). The combination of diabetes and smoking means a higher risk for oral precancerous lesions and malignancies.CONCLUSIONS -Diabetes may be a risk factor for oral premalignancies and tumors. Diabetes Care 27:770 -774, 2004C orrelations between diabetes and inflammatory oral lesions were first published in the 19th century (1). Gingivitis and destructive periodontitis with a rapid loss of the teeth were described as cardinal, pathognomic symptoms of diabetes (2,3).The discovery of insulin treatment justified a close correlation between the disorder of the carbohydrate metabolism and oral inflammatory complications (4). The adequate treatment of diabetes results in marked improvement of the gingival and periodontal lesions.Diabetes patients have further inflammatory complications of the oral mucosa. The decreased rate of saliva secretion and the low pH value result in chronic cheilitis and glossitis with progressive atrophy of the covering epithelial layer (5).The inflammation-mediated carcinogenesis is a well-known empirical fact, but the exact pathway of this transition has not been perfectly clarified until now (6 -9). Is there any correlation between diabetes and tumor genesis of the oral cavity? Surprisingly, there are no literature data concerning this problem. Accordingly, in the present study, we have attempted...

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“…Twenty three relevant studies were retrieved about incidence, including eight case-control studies (O'Mara et al, 1985;Risch et al, 1988;Vecchia et al, 1994;Kravchick et al, 2001;Ng et al, 2003;Rousseau et al, 2006;MacKenzie et al, 2011;Attner et al, 2012), fifteen cohort studies (Ragozzino et al, 1982;Adami et al, 1991;Wideroff et al, 1997;Tripathi et al, 2002;Zendehdel et al, 2003;Coughlin et al, 2004;Swerdlow et al, 2005;Jee et al, 2005;Inoue et al, 2006;Larssona et al, 2008;Li et al, 2011;Tseng et al, 2011;Zhang et al, 2012;Newton et al, 2012;Prizment., 2013), comprising a total of 643,683 patients with DM and 4,819,656 patients without DM. The characteristics of selected studies are summarized in Table 1.…”

Section: Description Of Studiesmentioning

confidence: 99%

“…The characteristics of selected studies are summarized in Table 1. In some studies, the integral number of male and female were not reported (O'Mara et al, 1985;Risch et al, 1988;Kravchick et al, 2001;Ng et al, 2003;Inoue et al, 2006;Rousseau et al, 2006;Attner et al, 2012;Prizment et al, 2013;Verlato et al, 2013), and two of them were only included with women (Tripathi et al, 2002;Prizment et al, 2013), also another two of them were only included with men (Larssona et al, 2008;Attner et al, 2012), so there were 279,508 male and 291,644 female patients with DM, 2,199,602 male and 1,742,232 female patients without DM, respectively. There were ten studies with North America region, eight for Europe region and five with Asia region, respectively.…”

Section: Description Of Studiesmentioning

confidence: 99%

Diabetes Mellitus Increases the Risk of Bladder Cancer: An Updated Meta-analysis

Yang

Xu²,

Sun³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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Purpose: Studies have indicated that diabetes mellitus (DM) is a risk factor for bladder cancer; however, not all evidence supports this conclusion. The aim of this meta-analysis was to collate and evaluate all primary observational studies investigating the risk of bladder cancer associated with DM. Methods: The PubMed and Google Scholar databases were searched to identify studies that estimated the association of DM and bladder cancer. Summary effect estimates were derived using a random-effects meta-analysis model. Results: A total of 23 studies (8 case-control studies, 15 cohort studies) including 643,683 DM and 4,819,656 non-DM cases were identified. Analysis of all studies showed that DM was associated with an increased risk of bladder cancer compared with non-DM overall (OR=1.68, 95% CI 1.32-2.13). Analysis of subgroups demonstrated this to be the case in both case-control studies (OR=1.59, 95% CI 1.28-1.97, I 2 =58%) and cohort studies (RR=1.70, 95% CI 1.23-2.33, I 2 =96%). There was no gender difference in DM-associated bladder cancer risk. Bladder cancer risk was increased in Asia and the North America region, but not in Europe. Furthermore, DM-associated bladder cancer risk was obviously higher in Asia than North America and Europe or in those with Caucasian ethnicity. With extension of follow-up time, the bladder cancer risk was not increased for the patients with DM. Conclusions: This meta-analysis provided further evidence supporting theDM association with a significantly higher risk of bladder cancer obtained from observational studies.

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Increased incidence of diabetes mellitus in the patients with transitional cell carcinoma of urinary bladder

Cited by 27 publications

References 17 publications

Diabetes mellitus and risk of bladder cancer: a meta-analysis

Diabetes mellitus and risk of bladder cancer: a meta-analysis

Diabetes and Oral Tumors in Hungary

Diabetes Mellitus Increases the Risk of Bladder Cancer: An Updated Meta-analysis

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