Increased incidence of cutaneous squamous cell carcinoma in lung transplant recipients taking long-term voriconazole

Feist, A.; Lee, Roy; Osborne, Stephanie; Lane, James R.; Yung, Gordon

doi:10.1016/j.healun.2012.05.003

Cited by 83 publications

(88 citation statements)

References 24 publications

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“…Skin rashes have been reported, with distribution over sun-exposed areas, consistent with phototoxic reactions (186). Chronic skin inflammation associated with this exposure appears to promote skin cancer, including squamous cell carcinoma and melanoma (189)(190)(191). Skin cancer surveillance is recommended when long-term voriconazole is used (192).…”

Section: Advances In Antifungal Therapy For Coccidioidomycosismentioning

confidence: 99%

Recent Advances in Our Understanding of the Environmental, Epidemiological, Immunological, and Clinical Dimensions of Coccidioidomycosis

et al. 2013

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SUMMARY Coccidioidomycosis is the endemic mycosis caused by the fungal pathogens Coccidioides immitis and C. posadasii . This review is a summary of the recent advances that have been made in the understanding of this pathogen, including its mycology, genetics, and niche in the environment. Updates on the epidemiology of the organism emphasize that it is a continuing, significant problem in areas of endemicity. For a variety of reasons, the number of reported coccidioidal infections has increased dramatically over the past decade. While continual improvements in the fields of organ transplantation and management of autoimmune disorders and patients with HIV have led to dilemmas with concurrent infection with coccidioidomycosis, they have also led to advances in the understanding of the human immune response to infection. There have been some advances in therapeutics with the increased use of newer azoles. Lastly, there is an overview of the ongoing search for a preventative vaccine.

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Section: Advances In Antifungal Therapy For Coccidioidomycosismentioning

confidence: 99%

Recent Advances in Our Understanding of the Environmental, Epidemiological, Immunological, and Clinical Dimensions of Coccidioidomycosis

et al. 2013

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“…Lund cancer may result in early lymph or blood metastasis, seriously affecting human health (Feist et al 2012). Currently, clinicians adopt surgery, chemotherapy, radiotherapy, hormonal therapy, biological molecular targeted therapy, and other comprehensive programs for the treatment of lung cancer patients.…”

Section: Discussionmentioning

confidence: 99%

“…Lung squamous carcinoma is a histological type of lung cancer, with progressively younger ages of onset; this may be characterized by early lymphatic or blood metastasis, and is a serious threat to human health (Feist et al, 2012). With the continuous development of functional genomics and the completion of the human genome project, scholars have identified a close correlation between tumor cell proliferation and migration and gene regulation (involving the complex activation and deactivation of various genes), which provides a novel and effective way for the treatment of cancer (Bastide et al, 2010;Kunert-Keil et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Effects of Cx43 gene modification on the proliferation and migration of the human lung squamous carcinoma cell line NCI-H226

Jp¹,

Wei²

2015

Genet. Mol. Res.

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ABSTRACT. In this study, the human lung squamous carcinoma cell line NCI-H226 was transfected with the recombinant plasmid pBudCE4.1_Cx43 to explore the role of the Cx43 gene in cell growth, cell cycle, and tumor migration. pBudCE4.1-Cx43 was transfected into human lung squamous carcinoma NCI-H226 cells using Lipofectamine TM2000. The mRNA and protein expressions of Cx43 in the transfected cells were detected by reverse transcriptase polymerase chain reaction and western blot analysis. The cell-cell communication was detected using the scratch dye tracer method and the cell cycle was detected by flow cytometry. The CCK-8 proliferation, scratch healing, and cell invasion assays were performed to evaluate the effect of the Cx43 gene transfection on the proliferation, migration, and invasive abilities of NCI-H226 cells. Cx43 mRNA and protein expressions and the fluorescence intensity in the scratch healing test were significantly higher in the experimental group than those in the control and blank groups (P < 0.05 and < 0.01, respectively). The CCK-8 proliferation assay and the scratch healing experiment revealed significantly inhibited NCI-H226 cell proliferation (especially 72 h after incubation) and cell migration, respectively, in the experimental group, compared to the control and 13110-13119 (2015) blank groups (P < 0.001 and <0.05, respectively). The transwell chamber test showed a statistically significant decrease in the invasive ability of NCI-H226 cells in the experimental group (P < 0.05). Therefore, Cx43 gene transfection could inhibit the migration of human lung squamous carcinoma cell line NCI-H226, thereby inhibiting tumor cell proliferation.

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“…However, voriconazole is highly effective against molds, and as reported above, is capable of reducing the incidence of IFIs to less than 10% in patients with hematologic diseases (less than 3% in the IMPROVIT trial) [Feist et al 2012;Singer et al 2012;Vadnerkar et al 2010;Vanacker et al 2008]. Therefore, some centers may decide not to use empiric treatment and opt for a purely preemptive strategy [Fera et al 2009;GarciaEffron et al 2010].…”

Section: Role Of Voriconazole In Secondary Prophylaxismentioning

confidence: 99%

Voriconazole and its clinical potential in the prophylaxis of systemic fungal infection in patients with hematologic malignancies: a perspective review

Zabalza

Gorosquieta

Equiza

et al. 2013

Therapeutic Advances in Hematology

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Invasive fungal infections (IFIs) have become high prevalence in patients with hematologic malignancies. Drug-based strategies for IFIs include various approaches such as prophylactic, empiric, preemptive, and directed treatment. Prophylaxis is an attractive strategy in high-risk patients, given the lack of reliable diagnostics and the high mortality rate associated with IFIs. Prophylaxis includes the use of antifungal drugs in all patients at risk. An ideal antifungal compound for prophylaxis should have a potent and broad activity, be available both orally and intravenously, and have a low toxicity profile. Voriconazole fulfills all these criteria. The clinical efficacy of voriconazole against the majority of fungal pathogens makes it potentially very useful for the prevention of IFIs in patients with hematologic malignancies. Voriconazole appears to be very effective for the primary and secondary prevention of IFIs in these patients and recipients of allogeneic hematopoietic stem-cell transplantation. Randomized controlled trials evaluating voriconazole as primary antifungal prophylaxis in patients with neutropenia treated for a variety of hematologic malignancies have been performed, confirming its value as a prophylactic agent. Voriconazole is generally safe and well tolerated; however, its use is also associated with a number of concerns. In most patients with hematologic malignancies there is the potential for pharmacokinetic drug-drug interactions given that voriconazole is metabolized through the P450 cytochrome system.

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Increased incidence of cutaneous squamous cell carcinoma in lung transplant recipients taking long-term voriconazole

Cited by 83 publications

References 24 publications

Recent Advances in Our Understanding of the Environmental, Epidemiological, Immunological, and Clinical Dimensions of Coccidioidomycosis

Recent Advances in Our Understanding of the Environmental, Epidemiological, Immunological, and Clinical Dimensions of Coccidioidomycosis

Effects of Cx43 gene modification on the proliferation and migration of the human lung squamous carcinoma cell line NCI-H226

Voriconazole and its clinical potential in the prophylaxis of systemic fungal infection in patients with hematologic malignancies: a perspective review

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