Increased Imaging Ligand Hydrophilicity and Improved Pharmacokinetic Properties Provides Enhanced In Vivo Targeting of Fibroblast Activation Protein
Radhika Narain,
Ian Nessler,
Paul Richardson
et al.
Abstract:In this work, the impact of physicochemical modifications on pharmacokinetics and in vivo targeting of a small molecule fibroblast activation protein inhibitor (FAPI) imaging ligand in a murine model of rheumatoid arthritis was evaluated. While similar ligands have been well-reported in oncology for molecular imaging and radiotherapy, there are limited reports of FAPI derivatives in targeted applications in immunology. As inflammation may increase both specific and non-specific delivery of targeted agents in g… Show more
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