Increased IL-6 Production by Monocytes and Keratinocytes in Patients with Psoriasis

IL-4 regulation of IL-6 production involves Rac/Cdc42- and p38 MAPK-dependent pathways in keratinocytes

“…Of these, IL-6 is interesting in that it is a multifunctional cytokine involved in immune and in¯ammatory responses, which stimulates proliferation of both epidermal cells and lymphocytes (Kishimoto, 1989;Krueger et al, 1991;Turksen et al, 1992). These properties make it a possible key component of the interaction between the epidermis and the immune system in in¯ammatory and auto-immune skin diseases such as psoriasis (Grossman et al, 1989;Neuner et al, 1991) and lichen planus (Yamamoto and Osaki, 1995). In these diseases, T-cell in®ltrates are frequently observed and thought to play an important role in sustaining a chronic in¯ammatory process.…”

The Role of Cytokines and Chemokines in the Development of Basal Cell Carcinoma

“…IL-6 is directly related to epidermal hyperproliferation in psoriasis (4). There are many experimental evidences that IL-6 is associated with BCC.…”

IL6 −174G>C polymorphism is associated with an increased risk of psoriasis but not response to treatment

“…Di Renzo et al (9) showed that the IL6 À174G>C polymorphism (rs1800795) can be considered as a significant variable for prognosis and management of psoriasis and is associated with responsiveness to TNF-a blockers in psoriasis. Furthermore, keratinocytes and monocytes in psoriasis are activated to produce increased amounts of IL-6, the cytokine that may mediate regulation of both local and systemic inflammatory reactions in psoriasis (10,11). Thus, functional polymorphisms in the IL6 promoter region 174G>C can affect therapeutic responses to anti-IL-6 approaches.…”