Increased Human Urotensin II Levels Are Correlated With Carotid Atherosclerosis in Essential Hypertension

Suguro, Toshiaki; Watanabe, Takuya; Ban, Yoshiyuki; Kodate, Syuusuke; Misaki, Asako; Hirano, Tsutomu; Miyazaki, Akira; Adachi, Mitsuru

doi:10.1016/j.amjhyper.2006.08.001

Cited by 84 publications

(60 citation statements)

References 30 publications

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“…In our present and previous studies 15,31) , plasma IR-U levels showed a closely positive correlation with carotid maximum IMT as well as BP, suggesting that U may become a reliable biomarker for atherosclerosis. Importantly, it is the first report that both increased plasma IR-U levels and carotid atherosclerosis showed a significantly independent association with VaD.…”

Section: Vsmc Mø Møsupporting

confidence: 80%

“…U in circulating blood is produced mainly by the cardiovascular system, liver, and kidneys 14) . Plasma levels of U are increased in vascular endothelial dysfunction-related diseases, such as hypertension, ischemic heart disease, congestive heart failure, diabetes mellitus, and renal failure, and are positively correlated with systolic blood pressure (BP) and severity of atherosclerosis [14][15][16] . U (molecular weight: 1388) is regarded as a biomarker for atherosclerosis and vascular disease 14) ; however, the association between U and VaD is not clear.…”

Section: Introductionmentioning

confidence: 99%

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Increased Plasma Urotensin-II and Carotid Atherosclerosis are Associated with Vascular Dementia

Ban

Watanabe

Suguro

et al. 2009

JAT

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Aim: Human urotensin-(U ) is a cyclic neuropeptide with potent vasoconstrictive activity in the vasculature. The expression of U and its receptor (UT) mRNA is detected at high levels in the brain. We evaluated the relationship between plasma U levels and vascular dementia (VaD) caused by stroke or atherosclerotic small vessel disease. Methods: Carotid artery intima-media thickness (IMT), plaques, plasma levels of immunoreactive U (IR-U ), and atherosclerotic biomarkers were determined in 42 patients with VaD, 197 with Alzheimer's disease (AD), and 47 non-demented elderly controls. Results: Age, gender, body mass index, systolic blood pressure (SBP), fasting plasma glucose, insulin, triglycerides, high-density lipoprotein cholesterol, leptin, and plasminogen activator inhibitor-1 levels were not significantly different among these groups. IR-U , low-density lipoprotein (LDL) cholesterol, lipoprotein(a), lipid peroxides, interleukin-6, and high-sensitive C-reactive protein (hs-CRP) levels, and maximum IMT were significantly higher in VaD than in AD patients or controls. IR-U level showed a significantly positive correlation with SBP or maximum IMT. Multivariate logistic regression analysis revealed a significantly independent association between IR-U levels or increased maximum IMT ( ≥ 1.1 mm) and VaD as compared with SBP, LDL cholesterol, and interleukin-6 levels. Conclusion: Increased plasma IR-U levels and carotid atherosclerosis may be involved in the pathogenesis and progression of VaD.

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Section: Vsmc Mø Møsupporting

confidence: 80%

Section: Introductionmentioning

confidence: 99%

Increased Plasma Urotensin-II and Carotid Atherosclerosis are Associated with Vascular Dementia

Ban

Watanabe

Suguro

et al. 2009

JAT

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“…The upper normal limit of IMT was 1.0 mm, and the lesions with a focal IMTX1.1 mm were defined as plaques. 10 The plaque score was calculated by summing all plaque thickness measurements in both carotid arteries. The severity of plaque score was graded as follows: none, 0; mild, 1.1-5; moderate, 5.1-10; and severe, X10.1.…”

Section: Carotid Ultrasound Investigationmentioning

confidence: 99%

“…The severity of plaque score was graded as follows: none, 0; mild, 1.1-5; moderate, 5.1-10; and severe, X10.1. 10 Carotid artery elastic parameters Internal diameter measurements were made by continuous tracing of the intima-lumen interfaces of the near and far walls. According to the Atherosclerosis Risk in Communities study protocol and Tomiyama's studies, [11][12][13] carotid strain was assessed as DD Â 100/Dd, where DD and Dd represent pulsatile distension and end-diastolic diameter, respectively.…”

Section: Carotid Ultrasound Investigationmentioning

confidence: 99%

Associations of serum salusin-alpha levels with atherosclerosis and left ventricular diastolic dysfunction in essential hypertension

Wang

et al. 2011

J Hum Hypertens

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Serum salusin-alpha, is decreased in essential hypertension and acute coronary syndrome. The study is aimed to explore whether serum salusin-alpha is associated with atherosclerosis and left ventricular (LV) diastolic dysfunction in essential hypertension. Echocardiography, carotid ultrasonography, brachial-ankle pulse wave velocity (BaPWV) and serum salusin-alpha levels were determined in 60 hypertensive patients (29 with and 31 without carotid plaque) and 30 normotensive controls. Hypertensive patients with plaque, compared with those without plaque or the controls, had the lowest values of salusin-alpha. Then the hypertensive patients were divided into left ventricular hypertrophy (LVH) and non-LVH groups according to the echocardiography. Similarly, hypertensive patients with LVH showed the lowest serum salusinalpha levels. In all subjects, serum salusin-alpha levels were negatively correlated with carotid mean-intimamedia thickness (IMT), BaPWV, left ventricle mass index (LVMI) and E/E 0 (r ¼ À0.488, Po0.001; r ¼ À0.381, Po0.001; r ¼ À0.294, P ¼ 0.006; r ¼ À0.303, P ¼ 0.005; respectively). Serum salusin-alpha levels were independent predictors of BaPWV, carotid strain, carotid distensibility, mean-IMT, LVMI and E 0 /A 0 (b ¼ À0.399, 0.283, 0.237, À0.346, À0.306, 0.469; P ¼ 0.002, 0.031, 0.016, 0.005, 0.012 and 0.001, respectively) in multiple linear regression models. These results suggest that serum salusin-alpha may be associated with atherosclerosis and LV diastolic dysfunction in essential hypertension.

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“…ÜT 2 ekspresyonu aynı zamanda aterosklorotik plaklarda vaskü-ler düz kas hücre proliferasyonunu stimule edebilir, daha da fazlası ÜT 2 lokal olarak koroner vazokonstriksiyona neden olabilir ve myokard iskemisini attırabilir [71]. Aterosklorozla ile ilgili yapılan deneysel çalışmalara baktığımız-da ise; Suguro ve arkadaşları [72] yaptığı bir çalışmada hipertansif hastalarda artan ÜT 2 seviyelerinin karotid aterosklerozunun gelişmesinde çok önemli bir rol oynadığını göstermişlerdir. Yine Suguro ve arkadaşları yaptığı bir başka çalışmada [73] artmış plazma ÜT 2 seviyesinin diyabetik retinopati ve karotid aterosklerozunun progresyonu ile ilişkili olduğunu göstermişlerdir.…”

Section: Aterosklerozunclassified

The Importence of Urotensin and Urotensin Receptors in Cardiovascular System

Köse¹

2014

Ann Clin Anal Med

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ÖzetBir siklik petid olan Ürotensin 2 (ÜT 2) yaklaşık 45 yıl önce keşfedilmiştir ve güçlü vazokonstriktör etkilerinin olmasından dolayı bilim camiası tarafından dikkat çekmiştir. ÜT 2 G proteinine bağlı bir reseptör olan "GPR14" reseptö-rüne bağlanarak etki gösterir. ÜT 2 ve reseptörü yaygın olarak periferik vasküler dokularda, kalp ve böbrekte dağılım göstermektedir. ÜT 2'nin sağlıklı insanda çok küçük bir role sahip olduğu belirtilmiş, hastalık durumlarında ise nispeten rolünün daha belirgin olduğuna değinilmiştir. ÜT 2'nin kardiyovaskü-ler etkileri insanda başlıca pozitif inotropi, vazokontsriksiyon ve vasküler yatağın ve endotelin durumuna bağlı vazodilatasyon ve vasküler düz kas hücre proliferasyonudur. Günümüzdeki araştırmalar ÜT 2'nin özellikle çeşitli kardiyovasküler hastalıklarda önemli bir rol oynadığını göstermiştir. ÜT 2 ve dolayısıyla ÜT 2 reseptörlerinin kardiyovasküler sistem üzerindeki etkileri günü-müzde oldukça çok çalışılan bir konu olmakla beraber literatürde bu konuyla ilgili çalışmalar ve bu çalışmalar sonucu elde edilen sonuçlar oldukça karı-şıktır. Kalp yetmezliğinde daha önceki çalışmalarda majör bir rol oynamadığı söylenmiş, daha sonraki çalışmalarda hastalığın patofizyolojisinde potansiyel role sahip olduğu gösterilmiştir. Ayrıca koroner kalp hastalığı ve iskemik kalp hastalığı ve aterosklerozda da ÜT 2 seviyesinin arttığı gösterilmiştir. Bu reseptörlerin fizyopatolojide mi rol oynadığı veya çok önemli bir savunma makanizması mı olduğu önemli bir araştırma konusu olmaktadır. Bu nedenle bu reseptörler bilim camiasında umut verici bir hedef olarak değerlendirilmekte-dir. Sonuç olarak bu reseptörlerin ileride çoğu hastalıkta özellikle kardiyovasküler hastalıkların gerek patofizyolojisi gerekse savunma mekanizmalarında kendilerine yer edineceğini ve daha fazla önem kazanacağını düşünmekteyiz. Anahtar KelimelerÜrotensin-2; Ürotensin Reseptörü; Endotel; Kalp Yetmezliği; Hipertansiyon Abstract Urotensin 2 (UT 2) which is a cyclic peptid was first identified about 45 years ago and due to its potent vasoconstrictor effect it has attracted the attention of the scientific community. UT 2 binds to a class of G protein-coupled receptor known as GPR14. Receptors for UT 2 are located on peripheral vascular smooth muscle, heart and kidney. In healthy people it has minor role, while in patients with disease it has a more prominent role. Main positive effects of UT 2 in cardiovasculer system are positive inotropic effect, vasoconsctruction, vascular smooth muscle cell proliferation, vasodilatation which related the state of endothelin and vascular bed. Recent investigations have showed that UT 2 plays an important role in cardiovascular diseases. Although the effects of UT 2 and UT 2 receptors on cardiovascular system is a quite extensively studied subject. The studies and the results obtained from these studies are somewhat complex. Previous studies in heart failure has demonstrated that these receptors do not play a major role in heart failure but in later studies it has been shown that these receptor...

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Increased Human Urotensin II Levels Are Correlated With Carotid Atherosclerosis in Essential Hypertension

Abstract: Our results suggest that increased levels of U-II may play a crucial role in the development of carotid atherosclerosis in hypertensive patients.

Cited by 84 publications

References 30 publications

Increased Plasma Urotensin-II and Carotid Atherosclerosis are Associated with Vascular Dementia

Increased Plasma Urotensin-II and Carotid Atherosclerosis are Associated with Vascular Dementia

Associations of serum salusin-alpha levels with atherosclerosis and left ventricular diastolic dysfunction in essential hypertension

The Importence of Urotensin and Urotensin Receptors in Cardiovascular System

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