Increased homocysteine levels exist in women with preeclampsia from early pregnancy

Abstract

Our results indicate that higher homocysteine levels exist in women with PE from early pregnancy and continue till delivery.

The evaluation of serum homocysteine, folic acid, and vitamin B12 in patients complicated with preeclampsia

“…Dodds et al showed that high homocysteine in early pregnancy is a risk factor for preeclampsia (8). In addition, elevated levels of homocysteine in women with preeclampsia exist from early pregnancy and remain high until delivery (15). Several studies have shown high concentrations of maternal serum homocysteine in preeclampsia (6, 7, 9, 18–20).…”

“…High levels of maternal serum homocysteine are associated with higher rates of pregnancy complications, but the evidence is conflicting (14). Previous studies have shown higher levels of homocysteine in preeclamptic women; they are detected in early pregnancy and remain elevated until delivery (15). Low maternal folate concentrations are associated with preeclampsia (9, 10, 16).…”

Identification of High-Risk Pregnancies in a Remote Setting Using Ambulatory Blood Pressure: The MINDI Cohort

“…Folic acid supplementation for the prevention of neural tube defects and low birthweight has been studied (74), but its use for the prevention of HDPs is still controversial. Although folic acid supplementation did not change SBP or DBP in women from Iran (75) or The Netherlands (62), and although folic acid levels were similar between normal and hypertensive pregnancies in India (76), it has been reported that folate supplementation decreased the risk of HDPs in populations from China (77) and Korea (78). The association of folic acid deficiency with increased odds of eMAP points toward a benefit of folic acid supplementation for the prevention of HDPs and aligns with the significant positive correlations of serum homocysteine with high MAP in women with pregnancy complicated by HDP in Pakistan (17).…”

Review of biomarkers to assess the effects of switching from cigarettes to modified risk tobacco products

“…It is biosynthesized from the amino acid methionine to which it can also be recycled in a process that involves folate and various B-vitamins (B6 and B12). When the upstream or downstream metabolic pathway of HCY is blocked or delayed for various reasons, it leads to the accumulation of HCY, causing hyperhomocysteinaemia which, although causing no symptoms, affects the interior lining of blood vessels, increasing the risk of atherosclerosis (Sun et al 2017); increases the risk of deep vein thrombosis (Kamat et al 2010, Ekim et al 2015 and pulmonary embolism (Cellai et al 2014); may be related to Alzheimer's disease (Sharma and Lipincott 2017) and other types of dementia (Xie et al 2017) and may be associated with pre-eclampsia in pregnancy (Sayyah-Melli et al 2016, Wadhwani et al 2016. Thus, hyperhomocysteinaemia is associated with various diseases, in particular CVD (Olkkonen 2012, Lathe et al 2014.…”