Increased Homocysteine Level in Indian Sickle Cell Anemia Patients

Pandey, Hareram; Mishra, Rahasya Mani; Pandey, Sweta; Saxena, Renu

doi:10.1007/s12291-011-0158-7

Cited by 12 publications

(13 citation statements)

References 8 publications

(7 reference statements)

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“…Drinking green tea, a healthpromoting beverage, has been common for more than 2000 years. 1) As researchers have found beneficial health applications for herbal extracts in the pharmaceutical and food areas, herbal tea products have attracted significant attention.…”

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confidence: 99%

Analysis of Green Tea Compounds and Their Stability in Dentifrices of Different pH Levels

Jang

Park

Ahn

et al. 2014

CHEMICAL & PHARMACEUTICAL BULLETIN

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In this study, green tea compounds (flavonoids, alkaloids, and phenolic acids) were analyzed in green tea-containing dentifrices, and their stability at different pH levels was evaluated. The compounds were separated under 0.01% phosphoric acid-acetonitrile gradient conditions and detected by photodiode array detector at 210, 280, 300, 335 nm. Column temperature was set at 20°C based on the results of screening various temperatures. Each compound showed good linearity at optimized wavelength as well as showing good precision and accuracy in dentifrices. Using this method, the stability of compounds was investigated in pH 4, 7, 8, and 10 solutions for 96 h, and in pH 7 and pH 10 solutions for 6 months. The green tea compounds were more stable at low pH levels; purine alkaloids were more stable than flavonoids. In particular, gallocatechin (GC), epigallocatechin (EGC), epigallocatechin gallate (EGCG), gallocatechin gallate (GCG), and myricetin almost disappeared in pH 10 solutions after 96 h. In dentifrices, the compounds were gradually decreased until 6 months in both pH types, while gallic acid was increased because of production of galloyl ester of other green tea compounds. Therefore, it is beneficial to adjust to as low a pH as possible when produce green teacontaining dentifrices.

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confidence: 99%

Analysis of Green Tea Compounds and Their Stability in Dentifrices of Different pH Levels

Jang

Park

Ahn

et al. 2014

CHEMICAL & PHARMACEUTICAL BULLETIN

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“…24 Pandey et al stated that the increased homocysteine level was found in Indian sickle cell anemia patients. 25 In the article Dhar et al 2004 stated that the plasma total homocysteine (tHcy) was significantly higher in the SCD subjects than the controls. 26 Lastly, in the pooled estimation of the overall studies is also showing the serum homocysteine level is statistically very highly significant in the subject of SCD.…”

Section: Discussionmentioning

confidence: 99%

“…26 Lastly, in the pooled estimation of the overall studies is also showing the serum homocysteine level is statistically very highly significant in the subject of SCD. 6,7,9,11,[20][21][22][23][24][25][26] conclusIon…”

Section: Discussionmentioning

confidence: 99%

Study of Serum Homocysteine Level Variations in Sickle Cell Disease: A Meta-analysis Study

Kamble¹,

Hisalkar²,

Padhyegurjar³

et al. 2020

Indian Journal of Medical Biochemistry

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Background: Serum homocysteine levels have been observed to be increased in sickle cell disease (SCD). The biological mechanism of synthesis and regulation of the homocysteine remains unclear. This meta-analysis aims to provide an overview of the serum homocysteine level changes and to discuss its significance in SCD. Materials and methods: This meta-analysis is to determine serum homocysteine level changes during SCD and was conducted under the PRISMA guidelines. Without language restrictions, the articles were identified through BioMed, Embase,

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“…Elevated plasma homocysteine concentration (hyperhomocysteinemia) is a risk factor for vascular disease in the general population, 6 and often occurs in both paediatric and adult SCD patients 7‐17 . The clinical significance of elevated homocysteine in SCD is unclear.…”

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confidence: 99%

“…5 Elevated plasma homocysteine concentration (hyperhomocysteinemia) is a risk factor for vascular disease in the general population, 6 and often occurs in both paediatric and adult SCD patients. [7][8][9][10][11][12][13][14][15][16][17] The clinical significance of elevated homocysteine in SCD is unclear. Other than a correlation with stroke, 9 no studies have assessed the association of hyperhomocysteinemia with microvascular or macrovascular events or damage in SCD.…”

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confidence: 99%

Homocysteine is associated with severity of microvasculopathy in sickle cell disease patients

et al. 2020

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Summary The pathophysiology of sickle cell disease (SCD) includes vasculopathy as well as anaemia. Elevated plasma homocysteine is a risk factor for vascular disease and may be associated with increased risk of vascular complications in SCD patients. In the present study, microvascular characteristics were assessed in the bulbar conjunctiva of 18 paediatric and 18 adult SCD patients, using the non‐invasive technique of computer‐assisted intravital microscopy. A vasculopathy severity index (SI) was computed to quantify the degree of microvasculopathy in each patient. Plasma homocysteine and several of its determinants [serum folate and vitamin B12, plasma pyridoxal‐5'‐phosphate (vitamin B6 status) and creatinine (kidney function)] were measured. Age was strongly correlated with microvasculopathy in the SCD patients, with the SI increasing about 0·1 unit per one‐year increase in age (P < 0·001). After adjusting for age, gender, B‐vitamin status and creatinine, homocysteine concentration was directly correlated with severity index (P < 0·05). Age and homocysteine concentration were independent predictors of microvasculopathy in SCD patients. It remains to be determined whether lowering homocysteine concentrations using appropriate B‐vitamin supplements (folate and vitamins B12 and B6) ‒ particularly if started early in life ‒ could ameliorate microvasculopathy and its associated complications in SCD patients.

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Increased Homocysteine Level in Indian Sickle Cell Anemia Patients

Cited by 12 publications

References 8 publications

Analysis of Green Tea Compounds and Their Stability in Dentifrices of Different pH Levels

Analysis of Green Tea Compounds and Their Stability in Dentifrices of Different pH Levels

Study of Serum Homocysteine Level Variations in Sickle Cell Disease: A Meta-analysis Study

Homocysteine is associated with severity of microvasculopathy in sickle cell disease patients

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