Increased heart rate with sleep disordered breathing in hypertrophic cardiomyopathy

A Non-Framework Multilevel Surgery May Reduce Mean Heart Rate in Patients with Very Severe Obstructive Apnea Having Confined Retroglossal Space and Framework

“…Kawano reported a positive Spearman correlation between apnea-hypopnea index (AHI) and mean heart rate in all three (24-h, wakefulness, and sleep) sections of time [10]. Konecny et al reported that heart rate elevation is most easily noticeable during sleep for OSA patients with hypertrophic cardiomyopathy [13]. This association between elevated heart rate and the severity of OSA presents not only during the daytime but also at night-time during sleep [9,10].…”

Sleep Apnea, Septal Myectomy, and the Valsalva/Mueller Maneuvers: Who Can Resist Loving Hemodynamic Physiology?

“…3 In the past 10 years, the connection between SDB and HCM has been under increasing investigation, and this effort has identified association between untreated SDB and several adverse characteristics relevant to HCM: worse functional New York Heart Association class, 4 worse peak exercise oxygen consumption, 5 more frequent atrial fibrillation and enlarged left atrial size (potent predictors of survival in HCM), 6,7 and increased mean heart rate (target of b-blocker therapy, the up-titration of which can be limited by side-effects in HCM). 8,9 In this editorial we will attempt to coalesce the evolving framework of SDB-HCM interaction with the findings from the informative manuscript by Cui et al 10 published in this issue of Mayo Clinic Proceedings. 10 The esteemed authors of this novel study reviewed HCM patients who underwent clinically indicated septal myectomy at a specialized HCM center of excellence.…”