Increased head circumference in schizophrenia

Bassett, Anne S.; Chow, Eva W.C.; Bury, Alison; Faizal, Ali; Haylock, Claire A.H.; Smith, G.; Lapointe, Jocelyne S.; Honer, William G.

doi:10.1016/s0006-3223(96)00288-0

Cited by 14 publications

(13 citation statements)

References 23 publications

(25 reference statements)

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“…We have found no relationship at all between head circumference at birth and in adulthood among patients with schizophrenia [11]. While five independent studies have found schizophrenia patients to have a significantly smaller head circumference at birth (typically in females) [11][12][13][14][15], other studies have found a disproportionately large head circumference in male schizophrenia patients in adulthood [11,16]. Beyond possible gender differences, these different results may reflect both normal and abnormal developmental phenomena.…”

Section: Stability Of This Antecedent Of Schizophreniacontrasting

confidence: 64%

Minor Physical Anomalies and Obstetric Complications in Schizophrenia

McNeil

Cantor‐Graae

2000

Aust N Z J Psychiatry

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Both MPA and OC should be included in batteries of methods for identifying individuals at an increased risk for schizophrenia. However, increased rates of MPA and OC are not pathognomonic for schizophrenia, but rather characterise individuals at risk of a much broader range of mental and physical abnormality, as well as normality. Minor physical anomalies and OC are not in themselves stigmatising, but their possible identification as markers for 'increased risk for schizophrenia' should be used judiciously. Further research is recommended regarding the MPA and OC patterns related to schizophrenia.

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Section: Stability Of This Antecedent Of Schizophreniacontrasting

confidence: 64%

Minor Physical Anomalies and Obstetric Complications in Schizophrenia

McNeil

Cantor‐Graae

2000

Aust N Z J Psychiatry

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“…Previous studies have involved linear evaluation of 'hat size' using a tape measure or derived from neuroimaging; while some have reported a slight reduction in cranial circumference, others have found either no difference or a slight enlargement (Bassett et al 1996;Ward et al 1996;Buckley et al 2002). It is not clear how these cranial measurements relate to 'true' facial size as determined on a 3D basis.…”

Section: Discussionmentioning

confidence: 99%

Three-Dimensional Laser Surface Imaging and Geometric Morphometrics Resolve Frontonasal Dysmorphology in Schizophrenia

Hennessy

Baldwin

Browne

et al. 2007

Biological Psychiatry

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“…Five additional features (short stature, microcephaly, macrocephaly, hypertelorism, hypotelorism) were determined post hoc to be present or absent, based on three continuous measurement variables (height, head circumference, and inner canthal distance) [Hall et al, 1989]. Height and maximum occipitofrontal head circumference (OFC) were measured to the nearest 0.1 cm as previously described [Bassett et al, 1996]. Height was used to de®ne short stature (height`10th percentile, 164.0 cm for males and`154.5 cm for females) [Hall et al, 1989].…”

Section: Subjects and Assessmentsmentioning

confidence: 99%

Patterns of dysmorphic features in schizophrenia

et al. 2001

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Congenital dysmorphic features are prevalent in schizophrenia and may reflect underlying neurodevelopmental abnormalities. A cluster analysis approach delineating patterns of dysmorphic features has been used in genetics to classify individuals into more etiologically homogeneous subgroups. In the present study, this approach was applied to schizophrenia, using a sample with a suspected genetic syndrome as a testable model. Subjects (n = 159) with schizophrenia or schizoaffective disorder were ascertained from chronic patient populations (random, n = 123) or referred with possible 22q11 deletion syndrome (referred, n = 36). All subjects were evaluated for presence or absence of 70 reliably assessed dysmorphic features, which were used in a three-step cluster analysis. The analysis produced four major clusters with different patterns of dysmorphic features. Significant between-cluster differences were found for rates of 37 dysmorphic features (P < 0.05), median number of dysmorphic features (P = 0.0001), and validating features not used in the cluster analysis: mild mental retardation (P = 0.001) and congenital heart defects (P = 0.002). Two clusters (1 and 4) appeared to represent more developmental subgroups of schizophrenia with elevated rates of dysmorphic features and validating features. Cluster 1 (n = 27) comprised mostly referred subjects. Cluster 4 (n = 18) had a different pattern of dysmorphic features; one subject had a mosaic Turner syndrome variant. Two other clusters had lower rates and patterns of features consistent with those found in previous studies of schizophrenia. Delineating patterns of dysmorphic features may help identify subgroups that could represent neurodevelopmental forms of schizophrenia with more homogeneous origins.

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Increased head circumference in schizophrenia

Cited by 14 publications

References 23 publications

Minor Physical Anomalies and Obstetric Complications in Schizophrenia

Minor Physical Anomalies and Obstetric Complications in Schizophrenia

Three-Dimensional Laser Surface Imaging and Geometric Morphometrics Resolve Frontonasal Dysmorphology in Schizophrenia

Patterns of dysmorphic features in schizophrenia

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