Increased Gustatory Response Score in Obesity and Association Levels with IL-6 and Leptin

Remla, Nesrine; Hadjidj, Zeyneb; Ghezzaz, Kamel; Moulessehoul, Soraya; Aribi, Mourad

doi:10.1155/2016/7924052

Cited by 9 publications

(5 citation statements)

References 51 publications

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“…Obese children had a shorter life expectancy by 20 years if they remain obese till young adulthood [ 1 ]. North African Countries and the region of Middle East just like the other developing countries are not spared from the issue of the world [ 2 , 3 ]. Genetics, metabolic, social, cultural and environmental factors interact as different cofactors for the development of obesity.…”

Section: Introductionmentioning

confidence: 99%

Influence of Interleukin-6 (174G/C) Gene Polymorphism on Obesity in Egyptian Children

Ibrahim

Gabre

Sallam

et al. 2017

Open Access Maced J Med Sci

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BACKGROUND:Obesity is a multi-factorial chronic disorder. A considerable number of studies have been performed to figure out whether there is an association between obesity and polymorphisms of gene IL-6 (174G/C), but the results are equivocal.AIM:This study aimed to find out whether the IL-6 (174G/C) gene was associated with the risk of developing obesity in Egyptian children.SUBJECTS AND METHODS:The study included 149 children and adolescents with age ranged between 9.5 – 18 years. Eighty-five of them were obese which BMIZ-score is > 2, and sixty-four children with BMIZ-score ≤ 2 served as control group. Serum level of IL-6 and genetic analysis for IL-6 (174G/C) gene polymorphism were done.RESULTS:Obese children had significantly higher serum levels of IL-6 as compared to those of control children (P = 0.003). A high percentage of IL-6 polymorphism GC was found in obese subjects (93.7%), while the control group had a higher percentage of IL-6 polymorphism GG (70.6 %).CONCLUSION:Our study showed that carriers of the C allele for the IL-6 (174G/C) polymorphism have higher BMI. As the G174C polymorphism is likely to affect IL-6 expression and its physiological regulation; consequently this polymorphism may affect adiposity.

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Section: Introductionmentioning

confidence: 99%

Influence of Interleukin-6 (174G/C) Gene Polymorphism on Obesity in Egyptian Children

Ibrahim

Gabre

Sallam

et al. 2017

Open Access Maced J Med Sci

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“…Leptin is primarily secreted by adipocytes, and circulates in lean subjects. Insulin, overfeeding, endotoxins, glucocorticoids, and cytokines increase leptin expression; fasting, testosterone, thyroid hormone, and exposure to cold temperature decrease leptin expression [ 32 – 34 ]. The leptin receptor (OB-R) activates Janus-activated kinase (JAK), signal transducers and activators of transcription (STAT), insulin receptor substrate, and the mitogen-activated protein kinase (MAPK) pathways [ 35 – 38 ].…”

Section: Introductionmentioning

confidence: 99%

Leptin/OB-R pathway promotes IL-4 secretion from B lymphocytes and induces salivary gland epithelial cell apoptosis in Sjögren's syndrome

Xie

et al. 2017

Oncotarget

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Sjögren's syndrome (SjS) is a chronic autoimmune epithelitis in which cell apoptosis promotes the formation of inflammatory lesions. We used immunohistochemistry and TUNEL to assay B cell infiltration and apoptosis in salivary gland tissue from 16-week-old NOD/LtJ mice with SjS. In co-cultures of primary salivary glandepithelial cells (SGECs) and spleen B cells, we assessed SGEC viability and apoptosis using CCK8 assays and flow cytometry. ELISAs were employed to assess cytokine levels in culture medium. Leptin protein, leptin receptor (OB-R), pro- and anti-apoptotic proteins, and Jak2/Stat3/ERK signaling molecules were analyzed using western blotting. B cell infiltration and salivary gland apoptosis were increased in salivary tissue from mice with SjS. Leptin treatment had no effect on cell viability or apoptosis among B cells and primary SGECs. B cell and SGEC co-culture systems showed that leptin increased apoptosis induced by B lymphocytes, reduced SGEC cell viability, and promoted IL-4 secretion from B cells. This suggests Leptin/OB-R signaling stimulates B cells-induced SGEC apoptosis via IL-4 secretion and OB-R-Jak2-Stat3 activation.

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“…TNF-alfa and IL-6 levels are also significantly higher in obese individuals [ 65 , 66 ], and they correlate with body weight, BMI, waist and hip circumferences, and waist–hip ratio [ 67 ]. It has been shown that obesity-induced low-grade inflammation (raised IL-1, IL-6, and TNF-alfa levels) activates stress kinases, including IKK, JNK, and p38 MAPK, in muscle and fat cells.…”

Section: Immunometabolic Depressionmentioning

confidence: 99%

Ghrelin as a Biomarker of “Immunometabolic Depression” and Its Connection with Dysbiosis

Gajewska,

Strzelecki,

Gawlik-Kotelnicka

2023

Nutrients

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Ghrelin, a gastrointestinal peptide, is an endogenous ligand of growth hormone secretagogue receptor 1a (GHSR1a), which is mainly produced by X/A-like cells in the intestinal mucosa. Beyond its initial description as a growth hormone (GH) secretagogue stimulator of appetite, ghrelin has been revealed to have a wide range of physiological effects, for example, the modulation of inflammation; the improvement of cardiac performance; the modulation of stress, anxiety, taste sensation, and reward-seeking behavior; and the regulation of glucose metabolism and thermogenesis. Ghrelin secretion is altered in depressive disorders and metabolic syndrome, which frequently co-occur, but it is still unknown how these modifications relate to the physiopathology of these disorders. This review highlights the increasing amount of research establishing the close relationship between ghrelin, nutrition, microbiota, and disorders such as depression and metabolic syndrome, and it evaluates the ghrelinergic system as a potential target for the development of effective pharmacotherapies.

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Increased Gustatory Response Score in Obesity and Association Levels with IL-6 and Leptin

Cited by 9 publications

References 51 publications

Influence of Interleukin-6 (174G/C) Gene Polymorphism on Obesity in Egyptian Children

Influence of Interleukin-6 (174G/C) Gene Polymorphism on Obesity in Egyptian Children

Leptin/OB-R pathway promotes IL-4 secretion from B lymphocytes and induces salivary gland epithelial cell apoptosis in Sjögren's syndrome

Ghrelin as a Biomarker of “Immunometabolic Depression” and Its Connection with Dysbiosis

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