Increased growth of Bifidobacterium and Eubacterium by germinated barley foodstuff, accompanied by enhanced butyrate production in healthy volunteers.

Kanauchi, Osamu; Fujiyama, Yoshihide; Mitsuyama, Keiichi; Araki, Yoshio; Ishii, Tomoo; Nakamura, Tomohiko; Hitomi, Yutaka; Agata, Kazue; Saiki, T; Andoh, A.H.; Toyonaga, Atsushi; Bamba, Tadao

doi:10.3892/ijmm.3.2.175

Cited by 76 publications

(88 citation statements)

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“…Cell growth was not evaluated from the optical density of the PY-ERF broth because ERF is insoluble and therefore rendered the broth opaque. However, our previous study showed a strong relationship between an increase in SCFA production and an increase in the growth of probiotics (24).…”

Section: Preparation Of Erf and Its Chemical Compositionmentioning

confidence: 99%

“…The utilization of ERF by intestinal microbiota and the accompanying production of organic acids were investigated using 7 representative anaerobic human intestinal bacterial strains, including 2 bifidobacterium strains (B. breve; JCM 1192 and B. longum; JCM 1217) and 2 lactobacilli strains (L. acidophilus; JCM 1132 and L. casei; JCM 1134) as probiotics, 2 bacteroides strains (B. distasonis; JCM 5825 and B. ovatus; JCM 5824) as opportunitistic microbiota, and the butyrate producing microbiota, Eubacterium limosum (E. limosum; JCM 6421). The composition of the culture medium (peptone-yeast medium; PY medium) and incubation conditions were the same as those reported previously (23,24). Briefly, test tubes containing 15 ml of PY medium were inoculated with 300 μl of preincubated steady state bacteria (3x10 7 CFU) and subsequently incubated anaerobically for 48 h at 37˚C.…”

Section: Preparation Of Erf and Its Chemical Compositionmentioning

confidence: 99%

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Preventive effects of enzyme-treated rice fiber in a restraint stress-induced irritable bowel syndrome model

Kanauchi

Mitsuyama²,

Komiyama³

et al. 2010

Int J Mol Med

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Abstract. Irritable bowel syndrome (IBS) is a common health issue that is characterized by abdominal pain, abnormal bowel movements, altered visceral perception, and abnormal metabolism of 5-hydroxy triptamine (serotonin; 5HT). The use of prebiotics or probiotics treatment for IBS has become increasingly important as an adjunct to pharmaceutical options. The aim of this study was to determine the efficacy of enzymetreated rice fiber (ERF) on an IBS model. We obtained a new prebiotic from defatted rice bran that was developed as an insoluble dietary fiber through amylase and hemicellulase treatment followed by removal of the soluble fraction. Containing ~70% hemicellulose, ERF is utilized by lactobacilli and subsequently converted to butyrate using Eubacterium limosum. We employed a restraint stress IBS model which involved the continuous application of stress for 4 h per day for 3 days. Polycarbophil Ca (PC) (500 mg/kg body weight) was used as a positive control and ERF was added to the diet at 4% in diet. During restraint stress, ERF significantly attenuated urgent fecal excretion, colonic mucosal 5HT secretion, and hyperalgesthesia compared with the control. ERF also significantly increased cecal butyrate production as well as total organic acid content. PC was only effective in regard to preventing increases in 5HT levels. Furthermore, there were no significant levels of proinflammatory markers CINC-1 and TNF-· among the groups. Although more detailed studies are needed, the ERF prebiotic demonstrated potency in attenuating major symptoms of IBS.

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Section: Preparation Of Erf and Its Chemical Compositionmentioning

confidence: 99%

Section: Preparation Of Erf and Its Chemical Compositionmentioning

confidence: 99%

Preventive effects of enzyme-treated rice fiber in a restraint stress-induced irritable bowel syndrome model

Kanauchi

Mitsuyama²,

Komiyama³

et al. 2010

Int J Mol Med

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“…The members of the genus Eubacterium are known to produce butyrate [18], degrade flavonoids (from vegetables, fruits, nuts, and tea) [19], and are implicated in steroid and bile transformation in intestine. Other members include…”

Section: Introductionmentioning

confidence: 99%

Gut microbiome diversity in acute infective and chronic inflammatory gastrointestinal diseases in North India

et al. 2016

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The disease profile in the Indian population provides a unique opportunity for studying the host microbiome interaction in both infectious (amebiasis) and autoimmune diseases like inflammatory bowel disease (IBD) from a similar environment and genetic background. Analysis of fecal samples from untreated amebic liver abscess (ALA) patients, Entamoeba histolytica (Eh)-negative and -positive asymptomatic individuals, and pus samples from naive ALA patients revealed a significant reduction in Lactobacillus in asymptomatic individuals (Eh ?ve) and ALA patients. Two anaerobic genera, namely Bacteroides and Peptostreptococcus, were detected in naive ALA pus samples. Analysis of fecal samples from amoebic colitis patients showed a significant decline in population of Bacteroides, Clostridium coccoides and leptum subgroup, Lactobacillus, Campylobacter, and Eubacterium, whereas a significant increase in Bifidobacterium was observed. Mucosa-associated bacterial flora analysis from IBD patients and healthy controls revealed a significant difference in concentration of bacteria among predominating and subdominating genera between ulcerative colitis (UC), Crohn's disease (CD) patients, and controls. In contrast to the mucosal studies, we found a significant increase in lactobacilli population in fecal samples of active UC patients. Another study revealed a significant decrease of Clostridium coccoides and leptum clusters in fecal samples of active UC patients along with decreased concentrations of fecal SCFAs, especially of nbutyrate, iso-butyrate, and acetate. We therefore found similar perturbations in gut microbiome in both infectious and autoimmune diseases, indicating inflammation to be the major driver for changes in gut microbiome.

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“…Research studies have suggested that short-chain fatty acids exert a therapeutic effect on some human beings and experimental animal diseases77 . Relative efficacy of short-chain fatty acids production was found to differ between intestinal microflora, ie, bifidobacteria, lactobacilli, bacteroidaseae, clostridia, and eubacteria 78 .…”

Section: Production Of Short-chain Fatty Acidsmentioning

confidence: 99%

Probiotics: Microbial Therapy for Health Modulation

Goel

Dilbaghi

Kamboj

et al. 2006

DSJ

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The human gastrointestinal tract is a complex ecosystem that harbours a rich and diverse microflora. These microbes live in harmony with the host and exert various beneficial effects on human health by their metabolic activities. However, in our modern life style, frequent and indiscriminate use of antibiotics has disturbed this microbial ecosystem, resulting in occurrence of various bowel diseases. Some live microbial food supplements can re-establish this microbial ecosystem. Such a group of microorganisms, which positively influences the intestinal microbiota by stimulating the growth of beneficial bacteria and suppressing the harmful ones, is collectively known as probiotics. These have been consumed in the form of fermented milk products for centuries. However, scientific interest in their use for health maintenance and disease prevention has emerged over the past few years only.Various scientific evidences show that probiotics help to reduce several disorders including diarrhea, inflammatory bowel diseases, urinary tract infections, hypertension, allergies, and cancer. Besides, probiotics exert several other benefits also to human beings and animals. Important issues in the probiotic therapy include selection of appropriate strain, its viability during storage, gut persistence potential and functional properties. Another category involved in gut health is prebiotics. These are non-digestible food ingredients, which beneficially affect the host by selectively stimulating the growth or activity of one or a limited number of beneficial bacteria in the colon. This review paper highlights the major health benefits of probiotic organisms, mechanisms of their action, criteria of selection, enumeration, and safety of their use for human health.

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Increased growth of Bifidobacterium and Eubacterium by germinated barley foodstuff, accompanied by enhanced butyrate production in healthy volunteers.

Cited by 76 publications

References 0 publications

Preventive effects of enzyme-treated rice fiber in a restraint stress-induced irritable bowel syndrome model

Preventive effects of enzyme-treated rice fiber in a restraint stress-induced irritable bowel syndrome model

Gut microbiome diversity in acute infective and chronic inflammatory gastrointestinal diseases in North India

Probiotics: Microbial Therapy for Health Modulation

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