Increased Glycosylation of Serum Albumin in Diabetes Mellitus

Dolhofer, Roswitha; Wieland, O.

doi:10.2337/diab.29.6.417

Cited by 129 publications

(32 citation statements)

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“…Because the turnover of human serum albumin is much more rapid (half-life of 15-20 days) than that of hemoglobin, the measurement of glycated albumin (GA) provides an index of glycemic control over a shorter period of time (2 weeks) than measurement of HbA1c [4][5][6]. However, the characteristics of GA have not been compared with those of HbA1c in a cross-sectional analysis, and there has been no comparison between the changes of HbA1c and GA during longitudinal follow-up from untreated hyperglycemia to a well-controlled state by drug therapy, nor any assessment of the correlation between these parameters during severe hyperglycemia and after improvement in diabetic patients.…”

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confidence: 99%

Comparison of Glycated Albumin (GA) and Glycated Hemoglobin (HbA1c) in Type 2 Diabetic Patients: Usefulness of GA for Evaluation of Short-term Changes in Glycemic Control

et al. 2007

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Abstract. We studied the cross-sectional relationship between GA and HbA1c in 142 type 2 diabetic patients who had an HbA1c level <7.5% for at least one year without fluctuation by more than 0.5%. We also followed the changes of GA and HbA1c in 18 type 2 diabetic patients for 16 weeks as they progressed from untreated severe hyperglycemia (HbA1c≥9.0%) to good glycemic control (HbA1c≤6.5%) by intensive insulin treatment. The annual mean levels of GA and HbA1c in the stably controlled patients showed a weak, but significant, correlation (r = 0.23, p<0.001) in the 142 diabetic patients. However, the GA/HbA1c ratio ranged widely from 2.0 to 4.0 showing a normal distribution (2.9 ± 0.34, M ± SE), although patients with conditions affecting albumin turnover or RBC lifespan were excluded from the study. The GA/HbA1c ratio was significantly higher when patients were in hyperglycemic than when glycemic control was good (3.5 ± 0.15 vs. 2.9 ± 0.07, M ± SE, p<0.01). GA decreased more rapidly than HbA1c during intensive insulin therapy, but the percent reduction of HbA1c eventually corresponded with that of GA by 16 weeks after the start of treatment. These results demonstrate that, although unknown influences on GA or HbA1c may exist, GA may be a useful marker for monitoring short-term variations of glycemic control during treatment of diabetic patients.

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confidence: 99%

Comparison of Glycated Albumin (GA) and Glycated Hemoglobin (HbA1c) in Type 2 Diabetic Patients: Usefulness of GA for Evaluation of Short-term Changes in Glycemic Control

et al. 2007

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“…In contrast, clinical studies have shown that GSA reflects improved glycaemic control as early as 1-2 weeks. 10 The exact half-lives of all glycated proteins have not yet been determined and it is possible that fructosamine and glycated total protein may be less clinically useful than the measurement of glycated albumin (GSA) where the half-life is known precisely.…”

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confidence: 99%

Does the Measurement of Serum Fructosamine Accurately Reflect Levels of Glycated Albumin in Insulin-Dependent Diabetes?

et al. 1987

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We have measured serum glycated albumin (GSA) by affinity chromatography and immunoturbidimetry, and serum fructosamine using a Cobas FARA analyser in blood samples from 37 type I diabetics and 21 healthy controls. Random blood glucose and glycated haemoglobin levels were also measured. Glycated haemoglobin (HbA1) correlated with glycated albumin and fructosamine in the diabetic group. A less clear relationship was found between glycated albumin and fructosamine. HbA1, GSA and fructosamine correlated poorly with random blood glucose levels. These data indicate that serum fructosamine levels do not accurately reflect those of glycated albumin, as has recently been suggested, in type I insulin-dependent diabetics where glycaemic control fluctuates more than in type II diabetics. It is postulated that the two methods reflect varying glycaemic levels to a different degree, thereby accounting for the disparity.

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“…However HbA1c may not be suitable for evaluation of short term variation in gly-cemic control because of long life span of erythrocytes (120 days). Because the turnover of human serum albumin is much more rapid (half life of 15-20 days) than that of hem-globin, the measurment of glycated albumin (GA) provides an index of glycemic control over a short period of time than the measurment of HbA1c 22,23 . A recent article on proliferative diabetic retinopathy (PDR) discusses the involvement of glycated albumin in stimulating angiogenesis in the retina.…”

Section: Discussionmentioning

confidence: 99%

Glycated Albumin and Microalbuminuria as Risk Factors in Diabetic Retinopathy of Type 2 Diabetes Mellitus

Kondaveeti¹,

R²,

Shaker³

2013

J Biol Sci Opin

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Diabetes mellitus (DM) is a major health problem with long-term micro and macrovascular complications. Diabetic retinopathy (DR) is a sight-threatening chronic complication of diabetes mellitus in adults. In this study, we determined the frequency of DR and the relationship between Glycated Albumin (GA) levels, duration of diabetes and Microalbuminuria with DR in type 2 diabetic patients. Two hundred and fourty seven type 2 diabetic patients participated in this study. In the first examination, retinopathy was evaluated by ophthalmoscopy through dilated pupil by experienced ophthalmologist. Based on their optic fundi findings they were classified into three groups; without retinopathy, had non-proliferative DR (NPDR) and had proliferative diabetic retinopathy (PDR). In addition, the patients were classified in three groups according to their GA levels; below 17 %, between 17 and 25% and above 25%. According to the duration of diabetes the patients were divided into three groups. First group consisted of patients who were diabetic for less than five years, the second group consists of patients who had diabetes for a period 6-10 years and the third group, who were diabetic for more than 10 years. According to our results, there was a significant relationship between duration of diabetes and DR (both nonproliferative and proliferative) (p<0.001). A similar relationship between PDR and Microalbuminuria(p<.001), between NPDR and Microalbuminuria(p<.01) was found. These results imply that duration of diabetes, GA level and Microalbuminuria are important risk factors for onset or progression of DR in type 2 DM.

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Increased Glycosylation of Serum Albumin in Diabetes Mellitus

Cited by 129 publications

References 0 publications

Comparison of Glycated Albumin (GA) and Glycated Hemoglobin (HbA1c) in Type 2 Diabetic Patients: Usefulness of GA for Evaluation of Short-term Changes in Glycemic Control

Comparison of Glycated Albumin (GA) and Glycated Hemoglobin (HbA1c) in Type 2 Diabetic Patients: Usefulness of GA for Evaluation of Short-term Changes in Glycemic Control

Does the Measurement of Serum Fructosamine Accurately Reflect Levels of Glycated Albumin in Insulin-Dependent Diabetes?

Glycated Albumin and Microalbuminuria as Risk Factors in Diabetic Retinopathy of Type 2 Diabetes Mellitus

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