Increased glycolysis correlates with elevated immune activity in tumor immune microenvironment

Jiang, Zhongshan; Liu, Zhixian; Li, Mengyuan; Cai, Chen; Wang, Xiaosheng

doi:10.1016/j.ebiom.2019.03.068

Cited by 118 publications

(123 citation statements)

References 33 publications

Supporting

Mentioning

114

Contrasting

Order By: Relevance

“…Yajuan Zhang revealed that tumor-associated macrophages regulate the glycolysis of tumor cells by modulating the phosphorylation of phosphoglycerate kinase PGK1 in tumor cells, thereby promoting the development of pleomorphic glioblastoma [7]. Highly glycolytic tumors exhibit an immunostimulatory tumor microenvironment that bypass immune checkpoints, such as PD-L1, in tumors [8].…”

Section: Introductionmentioning

confidence: 99%

Mining novel cell glycolysis related gene markers that can predict the survival of colon adenocarcinoma patients

Chen

Cao

et al. 2020

Bioscience Reports

View full text Add to dashboard Cite

Colon adenocarcinoma (COAD) is a malignant gastrointestinal tumor, often occurring in the left colon, that is regulated by glycolysis-related processes. In past studies, multiple genes that influence the prognosis for survival have been discovered through bioinformatics analysis. However, the prediction of disease prognosis using a single gene is not an accurate method. In the present study, a mechanistic model was established to achieve better prediction for the prognosis of COAD. COAD-related data downloaded from The Cancer Genome Atlas (TCGA）was correlated with the glycolysis process using gene set enrichment analysis (GSEA) to determine the glycolysis-related genes that regulate COAD. Using COX regression analysis, glycolysis-related genes associated with the prognosis of COAD were identified, and the genes screened to establish a predictive model. The risk scores of this model were correlated with relevant clinical data to obtain a connection diagram between the model and survival rate, tumor characteristic data, etc. Finally, genes in the model were correlated with cells in the tumor microenvironment, finding that they affected specific immune cells in the model. Seven genes related to glycolysis were identified (PPARGC1A, DLAT, 6PC2, P4HA1, STC2, ANKZF1, and GPC1) which affect the prognosis of patients with COAD and constitute the model for prediction of survival of COAD patients.

show abstract

Section: Introductionmentioning

confidence: 99%

Mining novel cell glycolysis related gene markers that can predict the survival of colon adenocarcinoma patients

Chen

Cao

et al. 2020

Bioscience Reports

View full text Add to dashboard Cite

show abstract

“…A study by Meng et al 200,201 unfolded that decreased glycolysis could gain increased anti-cancer effects of immunotherapy via induction of immune sensitive surface ligands. Functionally, the activated glycolytic process is positively correlated with immune evasion, 202,203 activities of tumor microenvironment (TME), 204 and cytokine storm, 205 contributing to an anti-PD-1/PD-L1 immunotherapy response. 201,204 Besides, glycolysis also boosts activated immune cell proliferation, including T cells and monocytes, leading to immune tolerance and resistance.…”

Section: Discussionmentioning

confidence: 99%

<p>Emerging Roles and Therapeutic Interventions of Aerobic Glycolysis in Glioma</p>

Han¹,

Shi²,

Cao³

et al. 2020

OTT

View full text Add to dashboard Cite

Glioma is the most common type of intracranial malignant tumor, with a great recurrence rate due to its infiltrative growth, treatment resistance, intra-and intertumoral genetic heterogeneity. Recently, accumulating studies have illustrated that activated aerobic glycolysis participated in various cellular and clinical activities of glioma, thus influencing the efficacy of radiotherapy and chemotherapy. However, the glycolytic process is too complicated and ambiguous to serve as a novel therapy for glioma. In this review, we generalized the implication of key enzymes, glucose transporters (GLUTs), signalings and transcription factors in the glycolytic process of glioma. In addition, we summarized therapeutic interventions via the above aspects and discussed promising clinical applications for glioma.

show abstract

“…Glycolytic activity increases anti-PD-1/PD-L1 immunotherapy effects via enhancing PD-L1 expression on tumor cells. Thus, glycolytic activity of the tumor cells could be a predictive factor for immunotherapy response in diverse cancers [11]. Many metabolic mechanisms are thought to be related to tumor immune escape and could serve as co-targets in immunotherapy [44].…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies have found that tumor glycolysis and tumor immune evasion are interdependent. Glycolytic activity was a stronger predictor for tumor immunity in a number of cancers, glycolysis could increase PD-L1 expression in tumors [11]. Li D et al assessed Glut-1 and hexokinase 2(HK-2) expression in metabolic reprogramming after irradiation.…”

Section: Introductionmentioning

confidence: 99%

The role of GLUT-1 in upregulation of PD-L1 expression after radiotherapy and PD-L1 is associated with a favourable overall survival in hypopharyngeal cancer

Shen

Zhou

2020

Preprint

View full text Add to dashboard Cite

KEYWORDSglucose transporter 1, programmed cell death ligand 1, radiotherapy, prognosis, hypopharyngeal cancer 2 Abstract Purpose: Although the alteration of tumor immunity after radiotherapy (RT) has been studied widely in recent years, how radiotherapy mediates tumor immunity and whether glycolysis is involved in the mediation in hypopharyngeal cancer are still unclear. This study aimes to determine whether radiotherapy regulates programmed cell death ligand 1( PD-L1) partly via glucose transporter 1(GLUT-1) expression and whether PD-L1 expression predicts overall survival (OS) in patients with hypopharyngeal cancer.Methods: PD-L1, Glut-1 expression and C D4+, CD8+ T cell were detected by immunohistochemistry analysis on 47 pre-RT and 25 post-RT specimens of hypopharyngeal cancer. The changes of these indicators before and after radiotherapy were compared, and their association with overall survival of patients were analyzed. Moreover, we used siRNA-GLUT-1 to inhibit GLUT-1 expression and determined whether GLUT-1 was a key factor involved in mediation of PD-L1 expression by RT in vitro. Results: In multivariate analysis, patients with higher PD-L1 expression (P=0.037), higher CD4+ T cell infiltration (P=0.016) and earlier clinical stage (P=0.019) had favourable OS. The PD-L1 expression and CD4+, CD8+ T cell increased significantly after RT. PD-L1 expression was correlated with Glut-1 in pre-RT (P=0.002), but not after-RT(P=0.051). The PD-L1 expression of FaDu cells was upregulated after RT, especially at 96h after RT in vitro. However, the PD-L1 expression of siRNA-GLUT-1 FaDu cells was significantly decreased at 96h after RT when compared with FaDu cells. Conclusion: The patients with high PD-L1 expression and CD4+ T cell infiltration might have favourable OS in hypopharyngeal cancer. RT could increase PD-L1 expression and alter tumor immunity, the expression of PD-L1 was correlated with Glut-1, and inhibiting GLUT-1 expression might decrease the expression of PD-L1. GLUT-1 might participate in the alteration of tumor immunity after RT.

show abstract

Increased glycolysis correlates with elevated immune activity in tumor immune microenvironment

Cited by 118 publications

References 33 publications

Mining novel cell glycolysis related gene markers that can predict the survival of colon adenocarcinoma patients

Mining novel cell glycolysis related gene markers that can predict the survival of colon adenocarcinoma patients

<p>Emerging Roles and Therapeutic Interventions of Aerobic Glycolysis in Glioma</p>

The role of GLUT-1 in upregulation of PD-L1 expression after radiotherapy and PD-L1 is associated with a favourable overall survival in hypopharyngeal cancer

Contact Info

Product

Resources

About