Increased glycine-amidated hyocholic acid correlates to improved early weight loss after sleeve gastrectomy

Kindel, Tammy L.; Krause, Crystal; Helm, Melissa C.; McBride, Corrigan L.; Oleynikov, Dmitry; Thakare, Rhishikesh; Alamoudi, Jawaher Abdullah; Kothari, Vishal; Alnouti, Yazen; Kohli, Rohit

doi:10.1007/s00464-017-5747-y

Cited by 14 publications

(15 citation statements)

References 32 publications

(40 reference statements)

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“…Previous studies regarding bile acid after LSG are conflicting, while one human study showed an immediate increase of serum bile acids after surgery yet two other human studies showed unchanged serum bile acids until 1 or 2 years after surgery, with only statistically non‐significant increase …”

Section: Discussionmentioning

confidence: 96%

Study of changes of obesity‐related inflammatory cytokines after laparoscopic sleeve gastrectomy

Salman

Nafea

et al. 2019

ANZ Journal of Surgery

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Background: Chronic inflammation in adipose tissue may play a substantial role in the pathogenesis of obesity-related metabolic disorders. The present study aims to evaluate the changes in adipocytokines, bile acids, fibroblast growth factor 19 (FGF-19) and proinflammatory cytokines 6 months after laparoscopic sleeve gastrectomy (LSG). Methods: This prospective study included 75 obese patients with body mass index >35 kg/m 2 who underwent LSG. All patients were recruited preoperatively and followed up post-operatively at 6 months, with laboratory assessment of their cytokines including adiponectin, leptin, resistin, bile acid, interleukin (IL)-6, IL-8, tumour necrosis factor-α, monocyte chemotactic protein-1, high-sensitivity C-reactive protein, plasminogen activator inhibitor-1, serum amyloid-A and FGF-19. Results: There were statistically highly significant changes regarding anthropometric parameters (weight, body mass index and waist-to-hip ratio), blood glucose and lipid profile as well as liver enzymes at 6 months post-sleeve gastrectomy. The present study showed that the levels of serum adiponectin and FGF-19 significantly increased at 6 months of follow-up after surgery (P < 0.001), while the levels of serum leptin, resistin, highsensitivity C-reactive protein, plasminogen activator inhibitor-1 and serum amyloid-A significantly decreased at 6 months of follow-up after surgery (P < 0.001). There were no significant differences regarding serum bile acid, IL-6, IL-8, tumour necrosis factor-α and monocyte chemotactic protein-1. Conclusion: Weight loss after LSG is associated with significant improvement of the adipokine levels towards anti-diabetic and anti-inflammatory profiles. Future studies should use a larger sample size and longer follow-up periods.

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Section: Discussionmentioning

confidence: 96%

Study of changes of obesity‐related inflammatory cytokines after laparoscopic sleeve gastrectomy

Salman

Nafea

et al. 2019

ANZ Journal of Surgery

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“…While GLCA inhibited CTRP-3 gene expression in adipocytes in vitro, TDCA and TLCA, as well as the unconjugated secondary bile acid deoxycholic acid, had no significant effects on CTRP-3 mRNA levels. Interestingly, taurohyocholic acid (known to be increased in cholestasis and upon sleeve gastrectomy for obesity) [31] strongly suppressed CTRP-3 expression. Unlike cholic acid or chenodeoxycholic acid, taurohyocholic acid has a third hydroxyl group in the α-conformation at the 6-position.…”

Section: Discussionmentioning

confidence: 99%

Downregulation of CTRP-3 by Weight Loss In Vivo and by Bile Acids and Incretins in Adipocytes In Vitro

Schmid

Gehl

Thomalla

et al. 2020

IJMS

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The adipokine CTRP-3 (C1q/TNF-related protein-3) exerts anti-inflammatory and anti-diabetic effects. Its regulation in obesity and during weight loss is unknown. Serum and adipose tissue (AT) samples were obtained from patients (n = 179) undergoing bariatric surgery (BS). Moreover, patients (n = 131) participating in a low-calorie diet (LCD) program were studied. CTRP 3 levels were quantified by ELISA and mRNA expression was analyzed in AT and in 3T3-L1 adipocytes treated with bile acids and incretins. There was a persistent downregulation of CTRP-3 serum levels during weight loss. CTRP-3 expression was higher in subcutaneous than in visceral AT and serum levels of CTRP-3 were positively related to AT expression levels. A rapid decrease of circulating CTRP-3 was observed immediately upon BS, suggesting weight loss-independent regulatory mechanisms. Adipocytes CTRP-3 expression was inhibited by primary bile acid species and GLP 1. Adipocyte-specific CTRP-3 deficiency increased bile acid receptor expression. Circulating CTRP-3 levels are downregulated during weight loss, with a considerable decline occurring immediately upon BS. Mechanisms dependent and independent of weight loss cause the post-surgical decline of CTRP-3. The data strongly argue for regulatory interrelations of CTRP-3 with bile acids and incretin system.

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“…Those who underwent RYGB had increased fasting and post-prandial PYY and GLP-1, which could have contributed to the rapid weight loss ( 185 ); this effect was seen less often in patients with gastric banding ( 185 ). Another study in adult patients showed higher bile acid (BA) subtype levels and suggested a possible BA's role in the surgical weight loss response after LSG ( 188 ). Adolescents have lower surgical complication rates than their adult counterparts, hence considering bariatric surgery earlier rather than waiting until adulthood has been entertained ( 180 ).…”

Section: Treatmentmentioning

confidence: 99%

Childhood and Adolescent Obesity: A Review

2021

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Obesity is a complex condition that interweaves biological, developmental, environmental, behavioral, and genetic factors; it is a significant public health problem. The most common cause of obesity throughout childhood and adolescence is an inequity in energy balance; that is, excess caloric intake without appropriate caloric expenditure. Adiposity rebound (AR) in early childhood is a risk factor for obesity in adolescence and adulthood. The increasing prevalence of childhood and adolescent obesity is associated with a rise in comorbidities previously identified in the adult population, such as Type 2 Diabetes Mellitus, Hypertension, Non-alcoholic Fatty Liver disease (NAFLD), Obstructive Sleep Apnea (OSA), and Dyslipidemia. Due to the lack of a single treatment option to address obesity, clinicians have generally relied on counseling dietary changes and exercise. Due to psychosocial issues that may accompany adolescence regarding body habitus, this approach can have negative results. Teens can develop unhealthy eating habits that result in Bulimia Nervosa (BN), Binge- Eating Disorder (BED), or Night eating syndrome (NES). Others can develop Anorexia Nervosa (AN) as they attempt to restrict their diet and overshoot their goal of “being healthy.” To date, lifestyle interventions have shown only modest effects on weight loss. Emerging findings from basic science as well as interventional drug trials utilizing GLP-1 agonists have demonstrated success in effective weight loss in obese adults, adolescents, and pediatric patients. However, there is limited data on the efficacy and safety of other weight-loss medications in children and adolescents. Nearly 6% of adolescents in the United States are severely obese and bariatric surgery as a treatment consideration will be discussed. In summary, this paper will overview the pathophysiology, clinical, and psychological implications, and treatment options available for obese pediatric and adolescent patients.

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Increased glycine-amidated hyocholic acid correlates to improved early weight loss after sleeve gastrectomy

Abstract: SG induced an early and persistent post-prandial surge in multiple bile acid subtypes. Increased G-hyocholic consistently correlated with greater early BMI loss. This study provides evidence for a role of BAs in the surgical weight loss response after SG.

Cited by 14 publications

References 32 publications

Study of changes of obesity‐related inflammatory cytokines after laparoscopic sleeve gastrectomy

Study of changes of obesity‐related inflammatory cytokines after laparoscopic sleeve gastrectomy

Downregulation of CTRP-3 by Weight Loss In Vivo and by Bile Acids and Incretins in Adipocytes In Vitro

Childhood and Adolescent Obesity: A Review

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