Increased genetic risk of hypertension in immunoglobulin A nephropathy but not in membranous nephropathy

Hypertension and IgA nephropathy: Role of clinical and familial factors in progression to renal failure

“…To our knowledge, only three studies have looked for association between outcome and family history of hypertension in patients with IgAN [6,14,15]. One was negative (most likely underpowered) [15]; all considered smaller and heterogeneous samples.…”

“…An increased frequency of parental hypertension has been reported also in patients with glomerulonephritis, with respect to the general population. Some, [6,13,14], but not all [15] have reported that, besides hypertension, positive family history for hypertension affects renal outcome. Such studies were performed on a small number of individuals [13,14] or in heterogeneous cohorts including patients with advanced renal failure at presentation [6].…”