Increased generation of reactive oxygen species in mononuclear blood cells from hypercholesterolemic patients

Krause, S.; Pohl, A.; Pohl, C.; Liebrenz, A.; Rühling, K.; Lösche, Wolfgang

doi:10.1016/0049-3848(93)90098-9

Cited by 30 publications

(20 citation statements)

References 15 publications

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“…Furthermore, a higher reactive oxygen species (ROS) and O2 ·− production have been reported in patients with hyperlipidemia. [25] All forms of DM are characterized by chronic hyperglycemia and the development of specific microvascular pathology. [262728] Hyperglycemia is accompanied by hyperlipidemia in diabetes.…”

Section: Discussionmentioning

confidence: 99%

Serum zinc and magnesium concentrations in type 2 diabetes mellitus with periodontitis

Pushparani¹,

Anandan²,

Theagarayan³

2014

J Indian Soc Periodontol

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Aim:The purpose of the study was to evaluate the serum levels of zinc (Zn) and magnesium (Mg) in type 2 diabetes mellitus (DM) with periodontitis patients and to correlate them with the levels of serum cholesterol, high density lipoprotein cholesterol (HDL-c), low density lipoprotein cholesterol (LDL-c), and triglycerides among the study subjects.Materials and Methods:A total of 600 subjects participated in the study, who were divided into four groups as control healthy individuals (group I), type 2 DM without periodontitis (group II), type 2 DM with periodontitis (group III), and periodontitis subjects without DM (group IV), matched for age, sex, and duration of diabetes. Serum concentrations of glucose, total cholesterol, triglycerides, HDL-c, Zn, and Mg were measured using enzymatic methods in an UV absorption spectrophotometer, and LDL-c was calculated using Friedwald's formula. Student's t-test, Pearson correlations, and analysis of variance (ANOVA) tests were used for statistical analysis.Results:The serum zinc level was found to be significantly increased in type 2 DM without periodontitis (group II) and periodontitis subjects without type 2 DM (group IV) (P < 0.0001), and the level was lowered in type 2 DM with periodontitis (group III) when compared to control. The serum Mg level was found to be significantly decreased (P < 0.0001) in group II, group III, and in group IV, when compared to control. We found a significant increased level of serum total cholesterol and LDL-c and decreased triglycerides and HDL-c in type 2 DM subjects with periodontitis (group III, P < 0.0001).Conclusion:Patients with DM and periodontitis had altered metabolism of Zn and Mg which were linked to increased values of serum cholesterol and LDL-c and decreased HDL-c, contributing to the progression and complications of type 2 DM with periodontitis.

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Section: Discussionmentioning

confidence: 99%

Serum zinc and magnesium concentrations in type 2 diabetes mellitus with periodontitis

Pushparani¹,

Anandan²,

Theagarayan³

2014

J Indian Soc Periodontol

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show abstract

“…On the other hand, several studies have reported the possible role of hyperlipidemia in periodontitis progression (25). It has been shown that hyperlipidemia causes an increase in white blood cell (WBC) activity (26, 27), which helps the progression of periodontal disease in adults (28, 29). This study was carried out on non-smoking subjects thus confounding relationships with the toxic effects of smoking were omitted.…”

Section: Discussionmentioning

confidence: 99%

The Association Between Hyperlipidemia and Periodontal Infection

Hagh¹,

Zakavi²,

Hajizadeh³

et al. 2014

Iran Red Crescent Med J

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Background:Periodontitis is a local chronic inflammatory condition of the supporting structures of the teeth resulting from a dental plaque biofilm attached to teeth surfaces. Recent studies have indicated that this oral disease may have effects on systemic health.Objectives:The aim of the present study was to evaluate the association between periodontitis and hyperlipidemia.Patients and Methods:This case-control study was conducted in Iran during March 2011. In this case-control study, levels of serum lipids in 45 subjects with periodontitis were measured and compared with 45 age, gender and body mass index (BMI) matched controls. Data were analyzed using student t-test and chi-square test with P < 0.05 as the limit of significance.Results:Mean values of total cholesterol (CHL) (periodontitis group = 218.11 ± 29.77, control group = 162.31 ± 48.24) and triglycerides (TG) (periodontitis group = 209.77 ± 44.30, control group = 125.60 ± 44.16) were significantly higher in the periodontitis group (P < 0.001). High-density lipoprotein (HDL) and low-density lipoprotein (LDL) cholesterol levels were higher in the case group, but this difference was not statistically significant. Frequency of pathological values of CHL and TG were significantly higher in cases compared with the controls (P = 0.002 and P = 0.015, respectively).Conclusions:This study indicates that hyperlipidemia may be associated with periodontal disease in healthy individuals; yet whether periodontitis causes an increase in levels of plasma lipids or whether hyperlipidemia is a risk factor for periodontal infection and cardiovascular disease, it needs further investigations.

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“…Hyperlipidemia is known to cause hyperactivity of white blood cells. 17 Hyperactivity of white blood cells, for example, because of an increased production of oxygen radicals, 18 has been shown to be associated with progressive periodontitis in adults. 19 We believe this to be the first scientific research within the odontostomatologic field that employs videocapillaroscopy for the morphofunctional evaluation of periodontal microcirculation in patients affected by hypercholesterolemia.…”

Section: Discussionmentioning

confidence: 99%

Periodontal Alteration of the Microcirculation and Hypercholesterolemia: A Possible Correlation?

Scardina¹,

Pisano²,

Cacioppo³

et al. 2011

Southern Medical Journal

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Objective: We evaluated the morphological and parametric characteristics of the periodontal microcirculation in patients diagnosed as having hypercholesterolemia and high levels of low-density lipoprotein (LDL). Methods:Forty patients were recruited, 20 of whom were affected by hypercholesterolemia and 20 of whom were considered healthy. A videocapillaroscopic examination was carried out on the periodontal mucosa in the proximity of the frenulum (II, V sextant). Results:The difference between the parameters of the hypercholesterolemia group and the control group was evaluated with the Mann-Whitney U-test for non-parametric ordinal data; the level of significance being P Ͻ 0.05. The videocapillaroscopy documented extremely significant differences between the two groups, regarding the following parameters: total diameter of the loop (P ϭ 0.0017), diameter of the afferent loops (P ϭ 0.0004), diameter of the efferent loops (P ϭ 0.00008) and periodontal density (P ϭ 0.0001). Conclusions:The capillaroscopic examination revealed a morphological alteration of the periodontal microcirculation in patients with hypercholesterolemia, which is an expression of peripheral vascular phlogosis.

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Increased generation of reactive oxygen species in mononuclear blood cells from hypercholesterolemic patients

Cited by 30 publications

References 15 publications

Serum zinc and magnesium concentrations in type 2 diabetes mellitus with periodontitis

Serum zinc and magnesium concentrations in type 2 diabetes mellitus with periodontitis

The Association Between Hyperlipidemia and Periodontal Infection

Periodontal Alteration of the Microcirculation and Hypercholesterolemia: A Possible Correlation?

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