Increased functional connectivity of white-matter in myotonic dystrophy type 1

Li, Jing; Li, Jie; Huang, Pei; Huang, Lina; Ding, Qingguo; Zhan, Linlin; Li, Mengting; Zhang, Jiaxi; Zhang, Hongqiang; Cheng, Lulu; Li, Huayun; Liu, Dongqiang; Zhou, Haiyan; Jia, Xize

doi:10.3389/fnins.2022.953742

Cited by 3 publications

(1 citation statement)

References 79 publications

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“…Quality sleep is essential for memory consolidation, neuronal repair, and overall brain health, with disruptions in sleep patterns linked to an increased risk of cognitive impairment (Künstler et al, 2023). Similarly, nutrition plays a vital role, with a balanced diet rich in antioxidants, omega-3 fatty acids, and vitamins supporting brain function and reducing inflammation, which are associated with MCI risk (Li et al, 2022). Understanding the intricate interplay between these lifestyle factors and their collective impact on cognitive health is crucial for developing effective preventive strategies against MCI and promoting successful aging.…”

Section: Discussionmentioning

confidence: 99%

A bibliometric analysis on the health behaviors related to mild cognitive impairment

Xiao,

Zhou,

Zhang

et al. 2024

Front. Aging Neurosci.

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BackgroundMild cognitive impairment (MCI) is commonly defined as a transitional subclinical state between normal aging and dementia. A growing body of research indicates that health behaviors may play a protective role against cognitive decline and could potentially slow down the progression from MCI to dementia. The aim of this study is to conduct a bibliometric analysis of literature focusing on health behaviors and MCI to summarize the factors and evidence regarding the influence of health behaviors on MCI.MethodsThe study performed a bibliometric analysis by retrieving publications from the Science Citation Index and Social Sciences Citation Index sub-databases within the Web of Science Core Collection. Utilizing VOSviewer and CiteSpace software, a total of 2,843 eligible articles underwent co-citation, co-keywords, and clustering analyses. This methodology aimed to investigate the current status, trends, major research questions, and potential future directions within the research domain.ResultsThe bibliometric analysis indicates that research on healthy behaviors in individuals with MCI originated in 2002 and experienced rapid growth in 2014, reflecting the increasing global interest in this area. The United States emerged as the primary contributor, accounting for more than one-third of the total scientific output with 982 articles. Journals that published the most articles on MCI-related health behaviors included “Journal of Alzheimer’s Disease,” “Neurobiology of Aging,” “Frontiers in Aging Neuroscience,” and other geriatrics-related journals. High-impact papers identified by VOSviewer predominantly cover concepts related to MCI, such as diagnostic criteria, assessment, and multifactorial interventions. Co-occurrence keyword analysis highlights five research hotspots in health behavior associated with MCI: exercise, diet, risk factors and preventive measures for dementia, cognitive decline-related biomarkers, and clinical trials.ConclusionThis study provides a comprehensive review of literature on health behavior in individuals with MCI, emphasizing influential documents and journals. It outlines research trends and key focal points, offering valuable insights for researchers to comprehend significant contributions and steer future studies.

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Section: Discussionmentioning

confidence: 99%

A bibliometric analysis on the health behaviors related to mild cognitive impairment

Xiao,

Zhou,

Zhang

et al. 2024

Front. Aging Neurosci.

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Imaging of the superficial white matter in health and disease

Van Dyken,

Khan,

Palaniyappan

2024

Imaging Neuroscience

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The superficial white matter, the layer of white matter immediately deep to the cortical grey matter, is a highly complex, heterogeneous tissue region comprising dense meshes of neural fibres, a robust population of interstitial neurons, and ongoing glial activity and myelination. It originates from the histologically distinct, developmentally vital subplate in the fetal brain, maintains thalamo-cortical connections throughout adult life, and is a necessary passage for all axons passing between the grey and white matter. Despite these features, the superficial white matter is among the most poorly understood regions of the brain, in part due to its complex makeup and the resulting difficulty of its study. In this review, we review our current knowledge of SWM anatomy, development, and response to disease. We discuss the unique challenges encountered in the neuroimaging of this region, including the lack of standard definition and the nonspecificity of neuroimaging markers amplified by the complexity of the tissue. We discuss recent innovations and offer potential pathways forward.

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Changes in white matter functional networks across late adulthood

Gao

Lawless

et al. 2023

Front. Aging Neurosci.

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IntroductionThe aging brain is characterized by decreases in not only neuronal density but also reductions in myelinated white matter (WM) fibers that provide the essential foundation for communication between cortical regions. Age-related degeneration of WM has been previously characterized by histopathology as well as T2 FLAIR and diffusion MRI. Recent studies have consistently shown that BOLD (blood oxygenation level dependent) effects in WM are robustly detectable, are modulated by neural activities, and thus represent a complementary window into the functional organization of the brain. However, there have been no previous systematic studies of whether or how WM BOLD signals vary with normal aging. We therefore performed a comprehensive quantification of WM BOLD signals across scales to evaluate their potential as indicators of functional changes that arise with aging.MethodsBy using spatial independent component analysis (ICA) of BOLD signals acquired in a resting state, WM voxels were grouped into spatially distinct functional units. The functional connectivities (FCs) within and among those units were measured and their relationships with aging were assessed. On a larger spatial scale, a graph was reconstructed based on the pair-wise connectivities among units, modeling the WM as a complex network and producing a set of graph-theoretical metrics.ResultsThe spectral powers that reflect the intensities of BOLD signals were found to be significantly affected by aging across more than half of the WM units. The functional connectivities (FCs) within and among those units were found to decrease significantly with aging. We observed a widespread reduction of graph-theoretical metrics, suggesting a decrease in the ability to exchange information between remote WM regions with aging.DiscussionOur findings converge to support the notion that WM BOLD signals in specific regions, and their interactions with other regions, have the potential to serve as imaging markers of aging.

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Increased functional connectivity of white-matter in myotonic dystrophy type 1

Cited by 3 publications

References 79 publications

A bibliometric analysis on the health behaviors related to mild cognitive impairment

A bibliometric analysis on the health behaviors related to mild cognitive impairment

Imaging of the superficial white matter in health and disease

Changes in white matter functional networks across late adulthood

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