Increased formation of neutrophil extracellular traps in patients with anti-N-methyl-d-aspartate receptor encephalitis

Qiao, Shan; Sun, Quanye; Zhou, Peng; Zhang, Shanchao; Wang, Zhi-Hao; Li, Haiyun; Wang, Aihua; Liu, Xuewu; Tao, Xiaofeng

doi:10.3389/fimmu.2022.1046778

Cited by 7 publications

(10 citation statements)

References 37 publications

(52 reference statements)

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“…Saf. 207, 111081. doi: 10.1016/j.ecoenv.2020 Nie, K., Bai, Q., Chen, C., Zhang, M., and Li, Y. (2022).…”

Section: Discussionunclassified

“…In addition, Elrys et al (2020) reported that under salt stress FA could promote the growth of wheat by reducing the level of active oxygen species and improving the antioxidant defense system. Potassium fulvic acid (PFA) is formed with FA by chelating K + and rich in exchangeable K (Qiao et al, 2022). Compared with FA, PFA has superior advantages in composition, performance, price and physiological activity Qiao et al, 2022;.…”

Section: Introductionmentioning

confidence: 99%

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Applications of Omics in Plant-Microbiome Interactions

Yang,

Wang,

Wang

2024

Frontiers Research Topics

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Frontiers is more than just an open access publisher of scholarly articles: it is a pioneering approach to the world of academia, radically improving the way scholarly research is managed. The grand vision of Frontiers is a world where all people have an equal opportunity to seek, share and generate knowledge. Frontiers provides immediate and permanent online open access to all its publications, but this alone is not enough to realize our grand goals. Frontiers journal seriesThe Frontiers journal series is a multi-tier and interdisciplinary set of openaccess, online journals, promising a paradigm shift from the current review, selection and dissemination processes in academic publishing. All Frontiers journals are driven by researchers for researchers; therefore, they constitute a service to the scholarly community. At the same time, the Frontiers journal series operates on a revolutionary invention, the tiered publishing system, initially addressing specific communities of scholars, and gradually climbing up to broader public understanding, thus serving the interests of the lay society, too. Dedication to qualityEach Frontiers article is a landmark of the highest quality, thanks to genuinely collaborative interactions between authors and review editors, who include some of the world's best academicians. Research must be certified by peers before entering a stream of knowledge that may eventually reach the public -and shape society; therefore, Frontiers only applies the most rigorous and unbiased reviews. Frontiers revolutionizes research publishing by freely delivering the most outstanding research, evaluated with no bias from both the academic and social point of view. By applying the most advanced information technologies, Frontiers is catapulting scholarly publishing into a new generation. What are Frontiers Research Topics?Frontiers Research Topics are very popular trademarks of the Frontiers journals series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area.

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“…Saf. 207, 111081. doi: 10.1016/j.ecoenv.2020 Nie, K., Bai, Q., Chen, C., Zhang, M., and Li, Y. (2022).…”

Section: Discussionunclassified

Section: Introductionmentioning

confidence: 99%

Applications of Omics in Plant-Microbiome Interactions

Yang,

Wang,

Wang

2024

Frontiers Research Topics

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“…Neutrophils may contribute to the pathology of CNS diseases by generating NETs. In a recent study on patients with anti-NMDAR encephalitis, the production of NET increased, and the NET levels were found to be correlated with the levels of IL-8, IL-6, and TNF-α ( 21 ). Neutrophils may enhance immune response via NET generation in AE pathology.…”

Section: Discussionmentioning

confidence: 99%

Predictive value of the neutrophil-to-lymphocyte ratio for treatment response in patients diagnosed with definite or probable autoimmune encephalitis/encephalopathy

Ogami,

Koh,

Miyamoto

et al. 2023

Front. Neurol.

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IntroductionAutoimmune encephalitis/encephalopathy (AE) is a complex and heterogeneous disease, making it difficult to predict the prognosis. The neutrophil-to-lymphocyte ratio (NLR) has emerged as a potential prognostic tool, but its usefulness remains a matter of debate. This study aimed to explore prognostic factors in cases of clinically definite or probable AE, including those with autoantibody-negative, or unknown status.MethodsData on patients diagnosed with definite or probable AE, including those with autoantibody-negative, or unknown status, were retrospectively collected from the admission records of our department between January 2013 and December 2022. These patients were then categorized into either a good- or poor-response group, based on their short-term treatment response. Clinical characteristics, auxiliary examinations, and treatments were compared between the two groups. A multivariable logistic regression model was constructed to identify independent predictors of poor short-term treatment response by Akaike information criterion backward stepwise method.ResultsA total of 31 patients were included in the final analysis, with 18 of them included in the poor-response group. In the univariable analysis, the poor-response group had a higher proportion of patients with a modified Rankin Scale (mRS) high score upon admission, female, epileptic seizures, or NLRs of 3.93 or higher than the good-response group (all p < 0.10). Furthermore, the multivariable logistic regression analysis revealed that the mRS score upon admission [OR: 5.51, 95% confidence intervals (CI): 1.29–23.50, p = 0.02], epileptic seizures (OR: 10.01, 95% CI: 1.16–86.66, p = 0.04), and NLRs of 3.93 or higher (OR: 11.37, 95% CI: 1.12–114.68, p = 0.04) were significantly associated with poor short-term treatment response.ConclusionThe NLR may play a supplementary role in predicting the short-term treatment response in patients diagnosed with definite or probable AE, including those with autoantibody-negative, or unknown status.

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“…In the context of tumorigenesis, NETs facilitate cancer metastasis by forming circulating tumor cell clusters, enhancing tumor cell adhesion to the endothelium and potentially increasing tumor cell extravasation 8,9 . Citrullinated histone H3 (H3Cit) is a central player in NET formation 10,11 . NETs have been reported to be involved in CRC development and metastasis 12,13 …”

Section: Introductionmentioning

confidence: 99%

“…8,9 Citrullinated histone H3 (H3Cit) is a central player in NET formation. 10,11 NETs have been reported to be involved in CRC development and metastasis. 12,13 Peptidyl arginine deiminase (PAD) enzymes are widely distributed in mammals and are closely related to cell development and differentiation.…”

mentioning

confidence: 99%

GSK484, an inhibitor of peptidyl arginine deiminase 4, increases the radiosensitivity of colorectal cancer and inhibits neutrophil extracellular traps

Wang

Zhang

et al. 2023

The Journal of Gene Medicine

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IntroductionColorectal cancer (CRC) is the third most common malignancy and a major cause of cancer‐related deaths. Peptidyl arginine deiminase 4 (PAD4 or PADI4) is expressed in neutrophils that, when activated, can drive the formation of neutrophil extracellular traps (NETs). PAD4 has been found to be upregulated in CRC patients and to predict a poor prognosis. This study is aimed at exploring the role of PAD4 inhibitor (GSK484) in NET formation and radioresistance in CRC.MethodsReverse transcriptase quantitative polymerase chain reaction and western blotting were used to measure PAD4 expression in CRC tissues and cells. GSK484, an inhibitor of PAD4, was investigated in the following functional assays in vitro: western blotting, clonogenic survival, colony formation, TUNEL, flow cytometry and transwell assays. Nude mouse xenograft models were applied to evaluate the effect of GSK484 on tumor growth in CRC in vivo. The formation of NETs influenced by GSK484 was also investigated.ResultsWe showed upregulation of PAD4 mRNA and protein in CRC tissues and cells. High expression of PAD4 was related to a poor prognosis in CRC patients. GSK484 treatment promoted the radiosensitivity of CRC cells and induced cell death by promoting DNA double‐strand breaks. Rescue experiments further verified that GSK484 inhibited the effects of PAD4 overexpression in irradiated CRC cells. Moreover, GSK484 injection strengthened the radiosensitivity of CRC and inhibited NET formation in vivo.ConclusionsPAD4 inhibitor GSK484 promotes the radiosensitivity of CRC and inhibits NET formation in vivo and in vitro.

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Increased formation of neutrophil extracellular traps in patients with anti-N-methyl-d-aspartate receptor encephalitis

Cited by 7 publications

References 37 publications

Applications of Omics in Plant-Microbiome Interactions

Applications of Omics in Plant-Microbiome Interactions

Predictive value of the neutrophil-to-lymphocyte ratio for treatment response in patients diagnosed with definite or probable autoimmune encephalitis/encephalopathy

GSK484, an inhibitor of peptidyl arginine deiminase 4, increases the radiosensitivity of colorectal cancer and inhibits neutrophil extracellular traps

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