Increased Fatty Acid Synthase Activity in Non-small Cell Lung Cancer Tissue Is a Weaker Predictor of Shorter Patient Survival than Increased Lipoprotein Lipase Activity

Overexpression of Fatty Acid Synthase in Middle Eastern Epithelial Ovarian Carcinoma Activates AKT and Its Inhibition Potentiates Cisplatin-Induced Apoptosis

“…In normal cells, FASN expression levels are relatively low, since fatty acid is generally supplied by dietary fatty acid. In contrast, FASN is expressed at significantly higher levels in a variety of human epithelial cancers including breast, thyroid, colon, ovary, lung and prostate (4)(5)(6)(7)(8)(9). Moreover, several reports have shown that FASN expression levels correlate with tumor progression, aggressiveness and metastasis (10)(11).…”

Fatty Acid Synthesis Pathway Genetic Variants and Clinical Outcome of Non-Small Cell Lung Cancer Patients after Surgery

“…Moreover, several reports have shown that FASN and related DNL enzymes play important roles in tumor cell survival at multiple levels (Chajes et al, 2006;Migita et al, 2009;Li et al, 2012a;Lin et al, 2013). In addition, over-expression of FASN or ACLY indicates poor prognosis of patients with malignancies, including breast cancer, nasopharyngeal carcinoma, colorectal, ovarian and prostate cancer, as well as NSCLC (Alo et al, 1996;Shurbaji et al, 1996;Ogino et al, 2008;Cerne et al, 2010;Rahman et al, 2012;Wang et al, 2012;Kao et al, 2013) .…”

Lipoprotein lipase in non-small cell lung cancer tissue is highly expressed in a subpopulation of tumor-associated macrophages

“…The evidence includes the observation that high LPL activity in non-small cell lung cancer (NSCLC) tissue, relative that in adjacent non-cancer lung tissue, is a predictor of shorter patient survival, independently of standard prognostic factors [4,23]. Further, LPL activity is highest in areas containing actively proliferating cells in a variety of human sarcomas and carcinomas [19].…”