Increased fat synthesis and limited apolipoprotein B cause lipid accumulation in the liver of broiler chickens exposed to chronic heat stress

Lu, Zhenwu; He, Xiaofang; B, B; Zhang, L; Li, J L; Jiang, Yun; Zhou, Guanghong; Gao, Feng

doi:10.3382/ps/pez056

Cited by 85 publications

(73 citation statements)

References 42 publications

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“…Our previous study has shown that LXRα pathway is an important pathway changed by chronic heat stress to regulate fat synthesis in the liver of broilers . Previous studies suggested that the mRNA expression level of LXRα can be enhanced under stress conditions, which can activate the mRNA expression of SREBP‐1c in the liver .…”

Section: Discussionmentioning

confidence: 99%

“…In birds, most fat is synthesized by the liver, and the liver X receptor α (LXRα) acts as the regulator of fat synthesis and governs the expression of lipogenic enzymes and transcription factors . Our previous study has demonstrated that chronic heat stress enhanced the fat synthesis in the liver of broilers by activating the LXRα pathway . In addition, the triglycerides (TG) synthesized by the liver need to transport to extrahepatic tissues by the very‐low‐density lipoprotein (VLDL), otherwise the excessive lipids will accumulate in the liver, even resulting in hepatic steatosis …”

Section: Introductionmentioning

confidence: 99%

“…7 Our previous study has demonstrated that chronic heat stress enhanced the fat synthesis in the liver of broilers by activating the LXR pathway. 8 In addition, the triglycerides (TG) synthesized by the liver need to transport to extrahepatic tissues by the very-low-density lipoprotein (VLDL), 9,10 otherwise the excessive lipids will accumulate in the liver, even resulting in hepatic steatosis. 11 Taurine, 2-aminoethanesulfonic acid, is a sulfur-containing -amino acid found in most animal tissues and plays an important role in several essential biological processes, such as antioxidant action, bile acid conjugation, maintenance of calcium homeostasis, osmoregulation, and membrane stabilization.…”

Section: Introductionmentioning

confidence: 99%

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Dietary taurine supplementation decreases fat synthesis by suppressing the liver X receptor α pathway and alleviates lipid accumulation in the liver of chronic heat‐stressed broilers

et al. 2019

J Sci Food Agric

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BACKGROUND Chronic heat stress can enhance fat synthesis and result in lipid accumulation in the liver of broilers. To investigate the effects and molecular mechanisms of dietary taurine supplementation on fat synthesis and lipid accumulation in the liver of chronic heat‐stressed broilers, 144 28 day‐old chickens (Arbor Acres) were randomly distributed to normal control (NC, 22 °C, basal diet), heat stress (HS, consistent 32 °C, basal diet), or heat stress plus taurine (HS + T, consistent 32 °C, basal diet +5.00 g kg−1 taurine) groups for a 14‐day feeding trial. RESULTS Compared with those of the HS group, dietary taurine supplementation significantly decreased the level of very‐low‐density lipoprotein and the activity of aspartate aminotransferase in plasma and the relative weight of liver in the HS + T group. In addition, dietary taurine supplementation also significantly decreased the levels of triglyceride, acyl‐CoA carboxylase (ACC) and fatty acid synthase (FAS), and suppressed the mRNA expression levels of liver X receptor α (LXRα), sterol response element‐binding protein 1c, ACC and FAS in the liver of chronic heat‐stressed broilers. Meanwhile, dietary taurine supplementation effectively alleviated lipid accumulation in the liver of broilers exposed to chronic heat stress. CONCLUSION Chronic heat stress significantly increased fat synthesis and resulted in excess lipid deposition in the liver of broilers. Dietary taurine supplementation can effectively decrease fat synthesis by suppressing the LXRα pathway and alleviate lipid accumulation in the liver of chronic heat‐stressed broilers. © 2019 Society of Chemical Industry

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Dietary taurine supplementation decreases fat synthesis by suppressing the liver X receptor α pathway and alleviates lipid accumulation in the liver of chronic heat‐stressed broilers

et al. 2019

J Sci Food Agric

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“…Generally, if nutrient intake is sufficient, the utilization rate of fat in the body increases, and the oxidation of non-esterified fatty acids (NEFAs) also increases. However, despite the decrease in livestock feed intake, such as in chickens and pigs, in a high-temperature environment, lipid accumulation in carcasses increases [ 27 , 28 ], implying that HS or high temperatures can reduce fat breakdown and increase fat storage metabolism in animals [ 27 ]. Although the energy demand for maintaining homeostasis increases during HS, adipose tissue contribution to energy production decreases [ 18 ].…”

Section: Discussionmentioning

confidence: 99%

Early Heat Exposure Effects on Proteomic Changes of the Broiler Liver under Acute Heat Stress

Kang

Shim

2021

Animals

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As environmental temperatures continue to rise, heat stress (HS) is having a negative effect on the livestock industry. In order to solve this problem, many studies have been conducted to reduce HS. Among them, early heat exposure has been suggested as a method for reducing HS in poultry. In this study, we analyzed proteomics and tried to identify the metabolic mechanisms of early heat exposure on acute HS. A total of 48 chicks were separated into three groups: CC (control groups raised at optimum temperature), CH (raised with CC but exposed acute HS at the 35th day), and HH (raised with CC but exposed early heat at the fifth day and acute HS at the 35th day). After the whole period, liver samples were collected for proteomic analysis. A total of 97 differentially expressed proteins were identified by acute HS. Of these, 62 proteins recovered their expression levels by early heat exposure. We used these 62 proteins to determine the protective effects of early heat exposure. Of the various protein-related terms, we focused on the oxidative phosphorylation, fatty acid metabolism, carbohydrate metabolism, and energy production metabolism. Our findings suggest the possibility of early heat exposure effects in acute HS that may be useful in breeding or management techniques for producing broilers with high heat resistance.

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“…It is known that heat stress changes the biochemical blood parameters in poultry (13,20,34,38). Increased serum triglyceride (TG) levels indicate the changes in fat metabolism during heat stress in quails and broilers (11,20,38).…”

Section: Discussionmentioning

confidence: 99%

The effects of dietary eggshell with membrane and olive leaf extract supplementation on performance, carcass characteristics and some biochemical parameters of quails exposed to heat stress

Erişir¹,

Özçelik²,

Azman³

et al. 2020

Ankara Üniversitesi Veteriner Fakültesi Dergisi

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This study was conducted to investigate the effects of eggshells with membrane (ESM), the eggshells with membrane that had absorbed olive leaf extract (ESM+OLE) and olive leaf extract (OLE) additives on the performance, immunity, and oxidantantioxidant metabolism of Japanese quails exposed to heat stress. In the experiment, a total of 128 fifteen-day-old quails were divided into 4 groups with 4 replicates. The control group was fed with a maize-soybean based basal diet; the ESM group was fed with a basal diet supplemented with 2% ESM; the ESM+OLE group was fed with a basal diet consisting of 2% ESM and 200 ppm olive leaf extract and the OLE group was fed with a basal diet supplemented with 200 ppm olive leaf extract. At the end of the study, carcass characteristics and blood parameters were determined. The highest daily body weight gain and the lowest feed conversion ratio were observed in the OLE group (P<0.05). OLE was added into feed, MDA levels in the liver and heart decreased significantly (P<0.001), whereas, GSH-Px and SOD activities in both tissues alongside the GSH levels in the heart increased significantly (P<0.001). The ESM was found to significantly reduce liver MDA levels (P<0.001), and increase GSH-Px activity in both tissues, along with SOD activity and GSH levels in the heart (P<0.001). Consequently, the addition of ESM and OLE to the diets positively affected daily body weight gain, serum triglyceride, liver, and heart tissue MDA levels in the quails exposed to heat stress.

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Increased fat synthesis and limited apolipoprotein B cause lipid accumulation in the liver of broiler chickens exposed to chronic heat stress

Cited by 85 publications

References 42 publications

Dietary taurine supplementation decreases fat synthesis by suppressing the liver X receptor α pathway and alleviates lipid accumulation in the liver of chronic heat‐stressed broilers

Dietary taurine supplementation decreases fat synthesis by suppressing the liver X receptor α pathway and alleviates lipid accumulation in the liver of chronic heat‐stressed broilers

Early Heat Exposure Effects on Proteomic Changes of the Broiler Liver under Acute Heat Stress

The effects of dietary eggshell with membrane and olive leaf extract supplementation on performance, carcass characteristics and some biochemical parameters of quails exposed to heat stress

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