Increased Expression of the Immediate-Early Gene Arc/Arg3.1 Reduces AMPA Receptor-Mediated Synaptic Transmission

Verde, Emiliano M. Rial; Lee-Osbourne, Jane; Worley, Paul F.; Malinow, Roberto; Cline, Hollis T.

doi:10.1016/j.neuron.2006.09.031

Cited by 367 publications

(280 citation statements)

References 69 publications

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“…This result is consistent with previous studies reporting that Arc/Arg3.1 may be involved in endocytosis of AMPA-type glutamate receptors and may prompt the internalization of AMPA receptors [3][4][5]. Although LTP, especially early-phase LTP, depends on NMDA receptors ( [36] for review), activation of AMPA receptors may improve memory function in rats and mice [37,38].…”

Section: Discussionsupporting

confidence: 92%

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Analyses of fear memory in Arc/Arg3.1-deficient mice: intact short-term memory and impaired long-term and remote memory

Yamada¹,

Homma²,

Tanemura³

et al. 2011

WJNS

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Activity-regulated cytoskeleton-associated protein (Arc/Arg3.1) was originally identified in patients with seizures. It is densely distributed in the hippocampus and amygdala in particular. Because the expression of Arc/Arg3.1 is regulated by nerve inputs, it is thought to be an immediate early gene. As shown both in vitro and in vivo, Arc/Arg3.1 is involved in synaptic consolidation and regulates some forms of learning and memory in rats and mice [1,2]. Furthermore, a recent study suggests that Arc/Arg3.1 may play a significant role in signal transmission via AMPA-type glutamate receptors [3-5]. Therefore, we conducted a detailed analysis of fear memory in Arc/Arg3.1-deficient mice. As previously reported, the knockout animals exhibited impaired fear memory in both contextual and cued test situations. Although Arc/Arg3.1-deficient mice showed almost the same performance as wild-type littermates 4 hr after a conditioning trial, their performance was impaired in the retention test after 24 hr or longer, either with or without reconsolidation. Immunohistochemical analyses showed an abnormal density of GluR1 in the hippocampus of Arc/Arg3.1-deficient mice; however, an application of AMPA potentiator did not improve memory performance in the mutant mice. Memory impairment in Arc/Arg3.1-deficient mice is so robust that the mice provide a useful tool for developing treatments for memory impairment.

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Section: Discussionsupporting

confidence: 92%

“…Arc/Arg3.1 may be involved in the endocytosis of AMPA-type glutamate receptors [3][4][5] by inducing the internalization of AMPA receptors. The morphological properties of AMPA receptors in Arc/Arg3.1-deficient mice were not, however, analyzed, and how AMPA receptor trafficking relates to impaired LTM remains unknown.…”

Section: Introductionmentioning

confidence: 99%

Analyses of fear memory in Arc/Arg3.1-deficient mice: intact short-term memory and impaired long-term and remote memory

Yamada¹,

Homma²,

Tanemura³

et al. 2011

WJNS

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“…Furthermore, the decrease in the expression level of Arc following infusion of antisense oligonucleotides into the rat hippocampus (Guzowski et al 2000) or the targeted deletion of Arc in the mouse ) interferes with hippocampal-dependent synaptic plasticity and learning and memory. One of the proposed roles of Arc in the regulation of synaptic plasticity is its involvement in a-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA)-type glutamate receptor endocytosis Rial Verde et al 2006;Shepherd et al 2006).…”

Section: Introductionmentioning

confidence: 99%

Bioluminescence imaging of Arc expression enables detection of activity-dependent and plastic changes in the visual cortex of adult mice

et al. 2010

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Induction of the activity-regulated cytoskeleton-associated protein gene (Arc), one of the immediate early genes, in the brain correlates with various sensory processes, natural behaviors, and pathological conditions. Arc is also involved in synaptic plasticity during development. Thus, in vivo monitoring of Arc expression is useful for the analysis of physiological and pathological conditions in the brain. Recently, in vivo imaging of Arc expression using various green fluorescent protein-based probes has been reported; however, these probes can only be applied for the detection of fluorescence signals from superficial layers of the cortex with some autofluorescence noise. Here, we generated a novel transgenic mouse strain to monitor the neuronal-activity-dependent Arc expression using bioluminescence signals in vivo. Because of the very high sensitivity with a high signal-to-noise ratio, we detected neuronal-activity-dependent plastic changes in the bioluminescence signal intensity in the mouse visual cortex after visual deprivation, suggesting structural plasticity after peripheral lesions in adults. We also detected drastic changes in bioluminescence signals after seizure induction with kainic acid. Our novel mouse strain will be valuable for the continuous monitoring of neuronal-activity-dependent Arc expression in the brain under physiological and pathological conditions.

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“…Arc has been implicated in AMPA receptor endocytosis during synaptic plasticity (Rial Verde et al, 2006;Waung et al, 2008;Peebles et al, 2010;Liu et al, 2012) and after hormone stimulation (Chen et al, 2014). Therefore, we tested the effects of GPER1 activation on the levels of several AMPA receptor subunits in membrane and cytosolic fractions from hippocampal slices.…”

Section: Gper1 Activation Stimulates Mtor Signaling Through Bdnf Releasementioning

confidence: 99%

A novel form of synaptic plasticity in field CA3 of hippocampus requires GPER1 activation and BDNF release

Briz¹,

Liu²,

Zhu³

et al. 2015

J Exp Med

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Increased Expression of the Immediate-Early Gene Arc/Arg3.1 Reduces AMPA Receptor-Mediated Synaptic Transmission

Cited by 367 publications

References 69 publications

Analyses of fear memory in Arc/Arg3.1-deficient mice: intact short-term memory and impaired long-term and remote memory

Analyses of fear memory in Arc/Arg3.1-deficient mice: intact short-term memory and impaired long-term and remote memory

Bioluminescence imaging of Arc expression enables detection of activity-dependent and plastic changes in the visual cortex of adult mice

A novel form of synaptic plasticity in field CA3 of hippocampus requires GPER1 activation and BDNF release

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