Increased expression of soluble fractalkine (CX3CL1) in systemic sclerosis – possible role in vascular inflammation

Elsergany, Mervat; Shahba, Abeer; Ghazy, Medhat; Bedewy, Mohammed M.; Bahr, Hoda M.; Hassan, Azza; Attia, Mohamed A.

doi:10.1016/j.ejr.2011.03.004

Cited by 5 publications

(2 citation statements)

References 28 publications

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“…Its soluble isoform has strong chemotactic properties and is pathophysiologically connected to various inflammatory conditions. 50,51 CX 3 CL1 is known to be increased in serum of SSc patients, 52,53 and its serum levels were recently shown to be associated with severe lung fibrosis on HRCT and low DLCO. 54 CX 3 CL1 also showed predictive abilities of SSc-ILD progression in a cohort of 292 SSc patients mostly associated with increasing extent of lung fibrosis and declining DLCO.…”

Section: Chemokine Ligand-1mentioning

confidence: 99%

Circulating biomarkers of systemic sclerosis – interstitial lung disease

Hoffmann‐Vold

Fretheim

Meier

et al. 2020

Journal of Scleroderma and Related Disorders

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Interstitial lung disease is a frequent organ manifestation in systemic sclerosis and is associated with high mortality. It is crucial to diagnose interstitial lung disease in systemic sclerosis and to assess severity and identify patients prone to progression at an early stage to ultimately decrease organ damage and improve outcome. Circulating anti-topoisomerase-I autoantibodies have long been associated with the presence and development of systemic sclerosis – interstitial lung disease, evidence on their potential to further predict the clinical course of systemic sclerosis is however conflicting. C-reactive protein is a marker of infection and systemic inflammation with widespread clinical application and is elevated in systemic sclerosis with a tendency towards higher abundancy in patients with early disease. The role of other circulating biomarkers is promising but hampered by the lack of standardized criteria and guidelines for sample/data collection, analyses, reporting and validation and has not reached prime time for clinical application. However, epithelial markers including Krebs von den Lungen-6 and surfactant protein D and several cytokines and chemokines including CCL2 and CCL18 for severity assessment of systemic sclerosis – interstitial lung disease patients at the time of interstitial lung disease diagnosis and to predict interstitial lung disease progression have been reported and seem to be promising candidate biomarkers in the future.

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Section: Chemokine Ligand-1mentioning

confidence: 99%

Circulating biomarkers of systemic sclerosis – interstitial lung disease

Hoffmann‐Vold

Fretheim

Meier

et al. 2020

Journal of Scleroderma and Related Disorders

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“…VEGF expression may enhance cytokines and growth factor signaling which could have effective implications on SSc pathogenesis. 10 Although data denotes a possible role of chemokines such as soluble fractalkine CX3CL1in the pathogenesis of SSc, 11 VEGF remains the most potent angiogenic molecule involved in vasculopathy in those patients. 12 Vitamin D is a steroid hormone responsible for regulation of bone metabolism and calcium homeostasis.…”

Section: Introductionmentioning

confidence: 99%

Vascular endothelial growth factor profile and Vitamin D level in Systemic Sclerosis Egyptian patients

Gharbawy

Sheha

Bawady

et al. 2021

EJI

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Vascular endothelial growth factor (VEGF) was described as a potentially important driver of systemic sclerosis (SSc) pathogenesis. Additionally, recent literature elucidated that vitamin D serum level was found to be significantly lower in SSc patients in comparison to healthy individuals. The aim of the current study was to evaluate serum level of VEGF and its correlation with clinical features and vitamin D level in systemic sclerosis (SSc) Egyptian patients. This current case control study included 30 female SSc patients and 20 healthy controls. VEGF level was measured by ELISA. Serum level of 25-OH vitamin D was measured by electrochemiluminescence. Nailfold video capillaroscopy and modified Rodnan skin score (mRSS) were assessed. Thirty SSc female patients were included in the study, 13 patients had diffuse cutaneous SSc. The mean age of the patients’ group was 49.3±4.3years, and the mean serum VEGF level was 3445.9±1183 ng/dl. The mean serum level of vitamin D was 15.57±9.9ng/ml in SSc patients and 30.6±2.26 in the controls. There was a significant association between high level of VEGF and hypovitaminosis D. Serum level of VEGF positively correlated with nailfold capillaroscopy changes and mRSS. In conclusion, high level of VEGF is associated with hypovitaminosis D, suggesting a role of vitamin D in SSc pathogenesis. VEGF levels correlate positively with nailfold capillaroscopy changes and extent of skin involvement.

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