Increased expression of PSA mRNA during brachytherapy in peripheral blood of patients with prostate cancer

Siddiqua, Ayisha; Damodaran, Chendil; Rowland, Randall G.; Meigooni, Ali S.; Kudrimoti, Mahesh; Mohiuddin, Mohammed; Ahmed, Mansoor M.

doi:10.1016/s0090-4295(02)01703-x

Cited by 11 publications

(11 citation statements)

References 26 publications

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“…Iatrogenic cellular shedding into the circulation occurs in clinical situations, for example, during transurethral resection of the prostate (TURP) [34,35], radical prostatectomy [36], prostate biopsy [37] and brachytherapy [38]. This cellular dissemination is unexpectedly not associated with a perceptible increase in metastasis development, perhaps because of the inability of individual cells to propagate or because of other unknown factors.…”

Section: Prostate Tumour Cell Clearance From Peripheral Bloodmentioning

confidence: 99%

Molecular mechanisms of metastasis in prostate cancer

Clarke

Hart²,

Brown³

2008

Asian J Androl

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Prostate cancer (PCa) preferentially metastasizes to the bone marrow stroma of the axial skeleton. This activity is the principal cause of PCa morbidity and mortality. The exact mechanism of PCa metastasis is currently unknown, although considerable progress has been made in determining the key players in this process. In this review, we present the current understanding of the molecular processes driving PCa metastasis to the bone.

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Section: Prostate Tumour Cell Clearance From Peripheral Bloodmentioning

confidence: 99%

Molecular mechanisms of metastasis in prostate cancer

Clarke

Hart²,

Brown³

2008

Asian J Androl

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“…For example, in prostate cancer there has been considerable discussion about tumor dissemination after hyperthermia or even diagnostic techniques, such as transurethral resection of the prostate (1,2). Because of the complex nature of the metastatic process, the relevance of tumor cells in the vasculature to long-term tumor metastasis remains controversial.…”

Section: Introductionmentioning

confidence: 99%

In Vivo Flow Cytometry

et al. 2004

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The fate of circulating tumor cells is an important determinant of their ability to form distant metastasis. Here, we demonstrate the use of in vivo flow cytometry as a powerful new method for detecting quantitatively circulating cancer cells. We specifically examine the circulation kinetics of two prostate cancer cell lines with different metastatic potential in mice and rats. We find that the cell line and the host environment affect the circulation kinetics of prostate cancer cells, with the intrinsic cell line properties determining the initial rate of cell depletion from the circulation and the host affecting cell circulation at later time points.

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“…39 The active release of these molecules in exosomes or microvesicles is another strong possibility. 40 Exosomes or microvesicles are released by living cells. They are membrane vesicles, 40 to 100 nm in diameter, 41 originating from the endoplasmic reticulum and are released when fused with the cell membrane.…”

Section: 33mentioning

confidence: 99%

“…60 An intriguing question that remains to be answered is the mechanism by which mRNA in saliva is protected by degradation. A speculation is that salivary mRNA is contained in apoptotic bodies 39,40 or actively released in exosomes or microvesicles. 42,44,46 Lately, microRNAs, small RNA molecules, 18 to 24 molecules in length, which seem to regulate transcription were also discovered existing in saliva.…”

Section: Altered Mrna Transcriptsmentioning

confidence: 99%

Utilization of Saliva as a Diagnostic Fluid in Determination of Oral Cancer

Vahanwala¹,

Mukherji²

2014

International Journal of Head and Neck Surgery

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Today's world technology has evolved and we have been able to evaluate certain phenomenon that occurs before manifestation of observable clinical symptoms. Every health care worker has a dream of a perfect diagnosis so that correct service whether medical or surgical, care can be facilitated to the patient. Cancer is one such disease where tracking the tell-tale signs is essential. The one factor behind oral cancer's high mortality is the challenge in its early detection. Despite the scepticism in the scientifi c community and the conservatism of the patients, saliva seems to emerge as a valuable tool in cancer diagnostics and mass screening of the population. An attempt to integrate the simultaneous testing of different salivary molecular markers in order to raise the possibility of an accurate diagnosis by simply using micro-and nanoelectricmechanical systems biosensors is on the way raising much hope in its future applications.

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Increased expression of PSA mRNA during brachytherapy in peripheral blood of patients with prostate cancer

Cited by 11 publications

References 26 publications

Molecular mechanisms of metastasis in prostate cancer

Molecular mechanisms of metastasis in prostate cancer

In Vivo Flow Cytometry

Utilization of Saliva as a Diagnostic Fluid in Determination of Oral Cancer

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