Increased Expression of Nerve Growth Factor Receptor and Neural Endopeptidase in the Lesional Skin of Melasma

Bak, Hana; Lee, Hyun Ju; Chang, Sung‐Eun; Choi, Jee‐Ho; Kim, Myeung Nam; Kim, Beom Joon

doi:10.1111/j.1524-4725.2009.01219.x

Cited by 28 publications

(22 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Recent studies have also examined the possible involvement of neural components in the pathogenesis of melasma [7,8,27]. Our results showed that GDA was the most up-regulated gene; there was a 9-fold increase in the degree of its expression.…”

Section: Discussionsupporting

confidence: 64%

“…Kang et al [6] demonstrated that fibroblasts showed a higher degree of expression of stem cell factors in the dermis and a higher degree of c-kit expression in the basal layer of the epidermis from melasma lesional skin. Bak et al [7] reported that the degree of immunohistochemical expression of nerve growth factor receptor was higher in keratinocytes in the lesional skin compared with normal adjacent one. Kim et al [8] also reported that the degree of the expression of vascular endothelial growth factor was higher in keratinocytes in the lesional skin compared with normal adjacent one.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Gene Expression Profiling in Melasma in Korean Women

Chung¹,

Noh²,

Yang³

et al. 2014

Dermatology

View full text Add to dashboard Cite

Background: There has been a paucity of data about the difference in gene expression between melasma lesional skin and normal adjacent one. Objective: Our aim was to identify novel genes involved in the pathogenesis of melasma. Methods: We performed a microarray analysis and confirmed the results on quantitative real-time polymerase chain reaction (qRT-PCR) in Korean women with melasma. Results: There were 334 genes whose degree of expression showed a significant difference between melasma lesional skin and normal adjacent one. Of these, five were confirmed on qRT-PCR. In melasma lesional skin, there were down-regulation of genes involved in the PPAR signaling pathway and up-regulation of genes involved in neuronal component and the functions of stratum corneum barrier. Conclusion: This result suggests that the pathogenesis of melasma might be associated with novel genes involved in the above signaling pathway in Korean women.

show abstract

Section: Discussionsupporting

confidence: 64%

Section: Introductionmentioning

confidence: 99%

Gene Expression Profiling in Melasma in Korean Women

Chung¹,

Noh²,

Yang³

et al. 2014

Dermatology

View full text Add to dashboard Cite

show abstract

“…An increase in the number of keratinocytes expressing NGFR ( nerve growth factor receptor ), neural endopeptidase and nerve fibers in the superficial dermis of the diseased skin was evidenced. 96 These findings support the hypothesis that neuropeptides may play a role in the development or maintenance of the disease.…”

Section: Etiology Physiopathology and Risk Factorssupporting

confidence: 72%

Melasma: a clinical and epidemiological review

Handel¹,

Miot

2014

An. Bras. Dermatol.

280

320

View full text Add to dashboard Cite

Melasma is a chronic acquired hypermelanosis of the skin, characterized by irregular brown macules symmetrically distributed on sun-exposed areas of the body, particularly on the face. It is a common cause of demand for dermatological care that affects mainly women (especially during the menacme), and more pigmented phenotypes (Fitzpatrick skin types III-V). Due to its frequent facial involvement, the disease has an impact on the quality of life of patients. Its pathogeny is not yet completely understood, although there are some known triggering factors such as sun exposure, pregnancy, sexual hormones, inflammatory processes of the skin, use of cosmetics, steroids, and photosensitizing drugs. There is also a clear genetic predisposition, since over 40% of patients reported having relatives affected with the disease. In this manuscript, the authors discuss the main clinical and epidemiological aspects of melasma.

show abstract

“…3,8 Studies have also examined the possibility of neural and vascular component and have revealed increased nerve growth factor receptor and vascular endothelial growth factor receptors in lesional keratinocytes. 9,10 Three clinical patterns of melasma have been defined. The centrofacial pattern is the most common and consists of lesions on the forehead, cheeks, nose, upper lip or chin.…”

mentioning

confidence: 99%