Increased expression of multidrug resistance-associated protein 1 (mrp1) in hepatocyte basolateral membrane and renal tubular epithelia after bile duct ligation in rats

Pei, Qiu; Kobayashi, Yoshinao; Tanaka, Yuji; Taguchi, Yukiko; Higuchi, Kunihiro; Kaito, Masahiko; Ma, Ning; Semba, Reiji; Kamisako, Toshinori; Adachi, Yukihiko

doi:10.1016/s1386-6346(01)00110-3

Cited by 49 publications

(22 citation statements)

References 20 publications

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“…Similar tissue distribution of Mrp1 has been noted in rats, dogs, mice, and cows (Stride et al, 1996;Conrad et al, 2001;Taguchi et al, 2002;Nunoya et al, 2003). In polarized epithelia of the intestine, kidney, liver, and lung, MRP1/Mrp1 is localized to basolateral plasma membranes of all species tested (Mayer et al, 1995;Peng et al, 1999;Pei et al, 2002;Scheffer et al, 2002b).…”

Section: Mrp Expression In the Central Nervous Systemsupporting

confidence: 69%

Multidrug Resistance-Associated Proteins: Expression and Function in the Central Nervous System

Dallas

Miller²,

Bendayan³

2006

Pharmacol Rev

267

207

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Section: Mrp Expression In the Central Nervous Systemsupporting

confidence: 69%

Multidrug Resistance-Associated Proteins: Expression and Function in the Central Nervous System

Dallas

Miller²,

Bendayan³

2006

Pharmacol Rev

267

207

View full text Add to dashboard Cite

“…Similar to what happens in the liver (except for Mrp2) and kidney Soroka et al, 2001;Pei et al, 2002), the adaptive up-regulation of several Mrp transporters in the rat trophoblast was stimulated by OCP.…”

Section: Treatment Of Maternal Cholestasis With Ursodeoxycholic Acid 521supporting

confidence: 61%

Effect of Ursodeoxycholic Acid on the Impairment Induced by Maternal Cholestasis in the Rat Placenta-Maternal Liver Tandem Excretory Pathway

Serrano

Macı́as²,

Vallejo³

et al. 2003

J Pharmacol Exp Ther

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We investigated the effects of ursodeoxycholic acid (UDCA; 60 g/day/100 g b.wt.) on the impairment induced by maternal obstructive cholestasis during pregnancy (OCP) in the rat placentamaternal liver tandem excretory pathway. A blunted catheter was implanted in the common bile duct on day 14 of pregnancy, and the tip was cut on day 21. [ 14 C]Glycocholate (GC) was then administered through the umbilical artery of "in situ" perfused placenta (placental transfer test) or through the maternal jugular vein (biliary secretion test), and GC bile output was measured. OCP impaired both GC placental transfer and maternal biliary secretion. UDCA moderately improved the latter but had a more marked beneficial effect on GC placental transfer. Histological examination revealed trophoblast atrophy and structural alterations, e.g., loss of apical membrane microvilli in OCP placentas. Gene expression level was investigated by real-time quantitative reverse transcription-polymerase chain reaction and Western blot analysis. OCP reduced both placental lactogen II (a trophoblastspecific gene) mRNA and the functional amount of epithelial tissue, determined by transplacental diffusion of antipyrin. Using a rapid filtration technique, impairment in the ATP-dependent GC transport across trophoblast apical plasma membranes obtained from OCP placentas was found. UDCA partially prevented all these changes. The expression level of organic anion transporters Oatp1, Oatp2, and Oatp4, and multidrug resistance-associated proteins Mrp1, Mrp2, and Mrp3 in whole placenta were not affected or were moderately affected by OCP but greatly enhanced by UDCA. In summary, UDCA partially prevents deleterious effects of OCP on the rat placenta-maternal liver tandem excretory pathway, mainly by preserving trophoblast structure and function.

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“…The prevention of toxicity due to a second toxic event following a recovery period of a short-term exposure is in support of a protective function as well (Notenboom et al, 2005). Furthermore, Mrp2 expression in the liver of rats was found to be down-regulated during cholestasis, but the expression of the basolateral proteins Mrp1, Mrp3, and Mrp4 was induced as was Mrp2 in the kidney (Pei et al, 2002;Tanaka et al, 2002;Denk et al, 2004). These up-regulated proteins may offer an alternative elimination route for accumulating compounds.…”

Section: Figmentioning

confidence: 85%

Increased Apical Insertion of the Multidrug Resistance Protein 2 (MRP2/ABCC2) in Renal Proximal Tubules following Gentamicin Exposure

Notenboom

Wouterse

Peters

et al. 2006

J Pharmacol Exp Ther

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Increased expression of multidrug resistance-associated protein 1 (mrp1) in hepatocyte basolateral membrane and renal tubular epithelia after bile duct ligation in rats

Cited by 49 publications

References 20 publications

Multidrug Resistance-Associated Proteins: Expression and Function in the Central Nervous System

Multidrug Resistance-Associated Proteins: Expression and Function in the Central Nervous System

Effect of Ursodeoxycholic Acid on the Impairment Induced by Maternal Cholestasis in the Rat Placenta-Maternal Liver Tandem Excretory Pathway

Increased Apical Insertion of the Multidrug Resistance Protein 2 (MRP2/ABCC2) in Renal Proximal Tubules following Gentamicin Exposure

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