Increased expression of matrix metalloproteinase 7 and 9 and membrane type 1‐matrix metalloproteinase in esophageal squamous cell carcinomas

Ohashi, Kenichi; Nemoto, Tetsuo; Nakamura, Kyoichi; Nemori, Ryoichi

doi:10.1002/(sici)1097-0142(20000515)88:10<2201::aid-cncr2>3.3.co;2-e

Cited by 93 publications

(60 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Esophageal carcinoma in the Japanese population comprises largely of squamous cell carcinoma, wherein it has been demonstrated that MMP-2 and MMP-3 expression is positively correlated with the depth of invasion, lymph node metastasis, and vessel permeation (Shima et al,1992). MMP-7, MMP-9, and MT1-MMP have also been shown to be closely associated with invasion depth and venous invasion in esophageal squamous cell carcinomas (Ohashi et al 2000). The implication of MMP-7 expression at the invasive front has been substantiated by its correlation with disease recurrence and shorter disease-free and overall survival time in esophageal cancer (Yamamoto et al 1999).…”

Section: Introductionmentioning

confidence: 99%

Increased expression of MMP-2 and MMP-9 in esophageal squamous cell carcinoma.

Samantaray

Sharma

Chattopadhyaya

et al. 2004

Journal of Cancer Research and Clinical Oncology

View full text Add to dashboard Cite

Increased levels of MMP-2 and MMP-9 proteins in ESCCs as compared to normal esophageal tissues suggest their association with esophageal tumorigenesis. Increased levels of these MMPs are observed in majority of dysplasias analyzed herein, indicating that these alterations may be early events in esophageal tumorigenesis. In-depth studies are warranted to determine their role in development and progression of esophageal cancer.

show abstract

Section: Introductionmentioning

confidence: 99%

Increased expression of MMP-2 and MMP-9 in esophageal squamous cell carcinoma.

Samantaray

Sharma

Chattopadhyaya

et al. 2004

Journal of Cancer Research and Clinical Oncology

View full text Add to dashboard Cite

show abstract

“…It is important to elucidate what molecules are directly related to change in invasion pattern. Production of matrix metalloproteinases in SESCCs has previously been reported, and this is increased in deep sm carcinomas [18]. E-cadherin, α, β, and γ-catenin are all well-preserved in sm carcinomas [14].…”

Section: Discussionmentioning

confidence: 71%

“…It is well known that the frequency of lymph node metastasis is quite different between intramucosal and submucosal carcinoma cases [13,24]. We previously reported values of 6.7% and 40.3%, respectively [18]. On the basis of a multivariate analysis, Tajima et al [25] concluded lymph node metastasis to be the most important factor determining prognosis with submucosal carcinomas.…”

Section: Discussionmentioning

confidence: 83%

Vertical and horizontal growth features of superficial esophageal squamous cell carcinomas: histopathological evaluation of endoscopically resected specimens

et al. 2002

Self Cite

View full text Add to dashboard Cite

Endoscopic mucosal resection (EMR) has been performed for intramucosal carcinomas with excellent results. To evaluate invasion depth of superficial esophageal squamous cell carcinomas (SESCCs) accurately, it is important to elucidate vertical and horizontal growth features. Using 179 specimens of SESCC taken by EMR, various factors associated with vertical and horizontal growth were examined pathologically to determine which were correlated with invasion depth, classified for this purpose into four levels, m1, m2, m3, and sm. Maximum tumor diameter, including high-grade intraepithelial neoplasia, differed between m1 and m2 cases and for invasive lesions between m2 and m3. Maximum tumor thickness varied between m1 and m2, m2 and m3, and m3 and sm. Multivariate analysis showed tumor thickness and diameter of invasion to be correlated with submucosal invasion. Tumor thickness and depth of the depressed lesions were correlated in depressed/flat type cases. In elevated type cases the thickness of the tumor did not differentiate between m3 and sm. Shape of the elevated lesion also influenced the invasion depth. Frequency of infiltrating type tumors, composed of irregular and small invading nests, was higher with sm than m3. To differentiate m3 and sm tumor the classification of gross type, thickness, depth of depressed lesions, shape of elevated lesions, and invasion patterns should all be evaluated.

show abstract

“…In this paper, the authors only found a relation with the invasive pattern for MMP-9 mRNA levels, and did not do so for MMP-1, -2, -7, and -11 [29]. Also, in esophagus carcinomas the expression of MMP-9 was more frequent in tumors, which were deeply invasive [30]. There is a lot of controversy about the expression of MMP-2 and -9 and histological grade.…”

Section: Discussionmentioning

confidence: 81%

“…MMPs were implicated in the invasion and metastasis in several tumors, and the relationship between the expression of MMP and the prognosis was described in SCC of several primary sites, such as the cervix [8,16], head, neck [9, 18-20, 24-26, 29, 38, 39], esophagus [21], and lung [35]. Also, MMP-9 was implicated in invasion depth and vascular invasion in SCCs of the esophagus [30] and it is also correlated with worse prognosis in lung adenocarcinoma [32].…”

Section: Introductionmentioning

confidence: 99%

The expression of metaloproteinases-2 and -9 is different according to the patterns of growth and invasion in squamous cell carcinoma of the penis

et al. 2006

View full text Add to dashboard Cite

Squamous cell carcinoma (SCC) of the penis is characterized by different patterns of growth and local invasion. The matrix metalloproteinases (MMPs) is a family of proteolytic enzymes that are involved in the degradation of extracellular matrix to allow the migration of tumor cells. The present study examined whether the expression of MMP-2 and -9 is correlated with the patterns of tumor growth and invasion in penile SCC. The expression of MMP-2 and -9 was examined immunohistochemically in samples of 115 patients. The cases were divided in three groups according to the patterns of growth and invasion: group 1, exophytic growth and pushing pattern of invasion; group 2, endophytic growth and invasion in large sheets of cells; and group 3, endophytic growth and invasion in small group or isolated cells. Tumors with MMP-2 and -9 overexpression are deeply invasive and present an invasion pattern of small groups of cells. Also, expression of MMP-2 changed from membrane to cytoplasm in invasive tumors, maybe representing activation of MMP-2. These findings allow us to conclude that the less differentiated tumors, which are more invasive and with a pattern of invasion in small group of cells, are associated with the overexpression of MMPs.

show abstract

Increased expression of matrix metalloproteinase 7 and 9 and membrane type 1‐matrix metalloproteinase in esophageal squamous cell carcinomas

Cited by 93 publications

References 31 publications

Increased expression of MMP-2 and MMP-9 in esophageal squamous cell carcinoma.

Increased expression of MMP-2 and MMP-9 in esophageal squamous cell carcinoma.

Vertical and horizontal growth features of superficial esophageal squamous cell carcinomas: histopathological evaluation of endoscopically resected specimens

The expression of metaloproteinases-2 and -9 is different according to the patterns of growth and invasion in squamous cell carcinoma of the penis

Contact Info

Product

Resources

About