Increased expression of LINC00323 correlates with tumor progression and poor prognosis of gastric cancer

Abstract

BACKGROUD/AIMS: LINC00323 is a novel lncRNA which has reported to play an important role in the development and recurrence in several cancers. However, the expression and predictive value of LINC00323 in gastric cancer (GC) remain mysterious. METHODS: LINC00323 expression in GC tissues and adjacent normal tissues was evaluated by quantitative reverse-transcription PCR (qRT-PCR). The relationship between LINC00323 expression and clinicopathological features and patients’ survival were analyzed. Univariate and multivariate survival analyses were performed. RESULTS: LINC00323 expression were found to be significantly increased in GC tissues. High expression of LINC00323 exerted a pro-tumor effect in the late stage of GC development. Kaplan-Meier analysis showed that patients with high LINC00323 were associated with poor overall survival (OS) and progression-free survival (PFS). Moreover, the combination of TNM stage and drinking status better identified GC patient outcome than those of TNM stage alone. CONCLUSIONS: Our data showed that LINC00323 overexpression might serve as a novel independent prognostic factor for survival of GC patients, suggesting LINC00323 was a potential biomarker and therapeutic target for GC.

Non-Coding RNA as Biomarkers and Their Role in the Pathogenesis of Gastric Cancer—A Narrative Review

“…Another potential oncogene in GC is LINC01226, as it promotes GC progression by enhancing stress-induced phosphoprotein 1 (STIP1) translocation from the cytoplasm to the nucleus and the stabilisation of β-catenin protein [176]. Furthermore, LINC00323 may be a potential biomarker and prognostic factor indicative of OS and PFS [177]. Other lncRNAs dysregulated in GC that interact with the Wnt/β-catenin cascade include SNHG11 [178], SNHG22 [179], LINC01503 [180], LINC01314 [181], LINC01225 [182], LINC01606 [183], LINC00665 [184], and testis-specific transcript Y-linked 15 (TTTY15) [185], amongst oteros.…”

“…2024, 25, x FOR PEER REVIEW 14 of 27 of β-catenin protein [176]. Furthermore, LINC00323 may be a potential biomarker and prognostic factor indicative of OS and PFS [177]. Other lncRNAs dysregulated in GC that interact with the Wnt/β-catenin cascade include SNHG11 [178], SNHG22 [179], LINC01503 [180], LINC01314 [181], LINC01225 [182], LINC01606 [183], LINC00665 [184], and testis-specific transcript Y-linked 15 (TTTY15) [185], amongst oteros.…”